Correlation of SARS-CoV-2 Infection with Hepatitis and Liver Disorders
The coronavirus infectious disease-2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has become a severe global health challenge. The primary target for this virus is the lung. However, SARSCoV- 2 can also attack other organs, including the kidney and liver. S...
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| Language: | English |
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Pasteur Institute of Iran
2021-09-01
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| Series: | Journal of Medical Microbiology and Infectious Diseases |
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| Online Access: | https://jommid.pasteur.ac.ir/article-1-369-en.html |
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| author | Kimia Kardani Azam Bolhassani Mona Kardani Elnaz Agi |
| author_facet | Kimia Kardani Azam Bolhassani Mona Kardani Elnaz Agi |
| author_sort | Kimia Kardani |
| collection | DOAJ |
| description | The coronavirus infectious disease-2019 (COVID-19) caused by severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2) has become a severe global
health challenge. The primary target for this virus is the lung. However, SARSCoV-
2 can also attack other organs, including the kidney and liver. Some
COVID-19 case reports demonstrated elevated liver enzymes such as aspartate
aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin.
Indeed, higher levels of liver enzymes occur in severe cases compared with mild
to moderate cases. The relationship between liver injury and COVID-19 might
be due to various possible reasons such as reactivation of pre-existing liver
disease, viral replication in hepatic cells causing direct cytotoxicity, liver
ischemia and hypoxia, cytokine storm, and drug-induced liver injury (DILI).
Thus, hepatitis prevention and care services are necessary during the COVID-
19 pandemic. For instance, drugs that might reactivate hepatitis B should not be
prescribed for treating COVID-19. Generally, the long-term effects of SARSCoV-
2 on human health and various organs are not well understood. This review
briefly discusses the relationship between SARS-CoV-2 and liver injury
(hepatitis), coinfection of hepatitis and COVID-19, and SARS-CoV-2 infection
in autoimmune hepatitis. |
| format | Article |
| id | doaj-art-a4593e8b3a2a42b0b6d9a2fe21939dd9 |
| institution | DOAJ |
| issn | 2345-5349 2345-5330 |
| language | English |
| publishDate | 2021-09-01 |
| publisher | Pasteur Institute of Iran |
| record_format | Article |
| series | Journal of Medical Microbiology and Infectious Diseases |
| spelling | doaj-art-a4593e8b3a2a42b0b6d9a2fe21939dd92025-08-20T02:55:28ZengPasteur Institute of IranJournal of Medical Microbiology and Infectious Diseases2345-53492345-53302021-09-019312213210.52547/JoMMID.9.3.122Correlation of SARS-CoV-2 Infection with Hepatitis and Liver DisordersKimia Kardani0https://orcid.org/0000-0003-0357-6331Azam Bolhassani1https://orcid.org/0000-0001-7363-7406Mona Kardani2https://orcid.org/0000-0003-1475-2863Elnaz Agi3https://orcid.org/0000-0003-3587-2952Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, IranDepartment of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, IranIranian Comprehensive Hemophilia Care Center, Tehran, IranIranian Comprehensive Hemophilia Care Center, Tehran, IranThe coronavirus infectious disease-2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has become a severe global health challenge. The primary target for this virus is the lung. However, SARSCoV- 2 can also attack other organs, including the kidney and liver. Some COVID-19 case reports demonstrated elevated liver enzymes such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin. Indeed, higher levels of liver enzymes occur in severe cases compared with mild to moderate cases. The relationship between liver injury and COVID-19 might be due to various possible reasons such as reactivation of pre-existing liver disease, viral replication in hepatic cells causing direct cytotoxicity, liver ischemia and hypoxia, cytokine storm, and drug-induced liver injury (DILI). Thus, hepatitis prevention and care services are necessary during the COVID- 19 pandemic. For instance, drugs that might reactivate hepatitis B should not be prescribed for treating COVID-19. Generally, the long-term effects of SARSCoV- 2 on human health and various organs are not well understood. This review briefly discusses the relationship between SARS-CoV-2 and liver injury (hepatitis), coinfection of hepatitis and COVID-19, and SARS-CoV-2 infection in autoimmune hepatitis.https://jommid.pasteur.ac.ir/article-1-369-en.htmlsars-cov-2covid- 19liver disordershepatitismechanism of action |
| spellingShingle | Kimia Kardani Azam Bolhassani Mona Kardani Elnaz Agi Correlation of SARS-CoV-2 Infection with Hepatitis and Liver Disorders Journal of Medical Microbiology and Infectious Diseases sars-cov-2 covid- 19 liver disorders hepatitis mechanism of action |
| title | Correlation of SARS-CoV-2 Infection with Hepatitis and Liver Disorders |
| title_full | Correlation of SARS-CoV-2 Infection with Hepatitis and Liver Disorders |
| title_fullStr | Correlation of SARS-CoV-2 Infection with Hepatitis and Liver Disorders |
| title_full_unstemmed | Correlation of SARS-CoV-2 Infection with Hepatitis and Liver Disorders |
| title_short | Correlation of SARS-CoV-2 Infection with Hepatitis and Liver Disorders |
| title_sort | correlation of sars cov 2 infection with hepatitis and liver disorders |
| topic | sars-cov-2 covid- 19 liver disorders hepatitis mechanism of action |
| url | https://jommid.pasteur.ac.ir/article-1-369-en.html |
| work_keys_str_mv | AT kimiakardani correlationofsarscov2infectionwithhepatitisandliverdisorders AT azambolhassani correlationofsarscov2infectionwithhepatitisandliverdisorders AT monakardani correlationofsarscov2infectionwithhepatitisandliverdisorders AT elnazagi correlationofsarscov2infectionwithhepatitisandliverdisorders |