Correlation of SARS-CoV-2 Infection with Hepatitis and Liver Disorders
The coronavirus infectious disease-2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has become a severe global health challenge. The primary target for this virus is the lung. However, SARSCoV- 2 can also attack other organs, including the kidney and liver. S...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Pasteur Institute of Iran
2021-09-01
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| Series: | Journal of Medical Microbiology and Infectious Diseases |
| Subjects: | |
| Online Access: | https://jommid.pasteur.ac.ir/article-1-369-en.html |
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| Summary: | The coronavirus infectious disease-2019 (COVID-19) caused by severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2) has become a severe global
health challenge. The primary target for this virus is the lung. However, SARSCoV-
2 can also attack other organs, including the kidney and liver. Some
COVID-19 case reports demonstrated elevated liver enzymes such as aspartate
aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin.
Indeed, higher levels of liver enzymes occur in severe cases compared with mild
to moderate cases. The relationship between liver injury and COVID-19 might
be due to various possible reasons such as reactivation of pre-existing liver
disease, viral replication in hepatic cells causing direct cytotoxicity, liver
ischemia and hypoxia, cytokine storm, and drug-induced liver injury (DILI).
Thus, hepatitis prevention and care services are necessary during the COVID-
19 pandemic. For instance, drugs that might reactivate hepatitis B should not be
prescribed for treating COVID-19. Generally, the long-term effects of SARSCoV-
2 on human health and various organs are not well understood. This review
briefly discusses the relationship between SARS-CoV-2 and liver injury
(hepatitis), coinfection of hepatitis and COVID-19, and SARS-CoV-2 infection
in autoimmune hepatitis. |
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| ISSN: | 2345-5349 2345-5330 |