The Topographic Relationships and Geographic Distribution of Prevascular Vitreous Fissures and Cisterns Assessed by Ultrawidefield En Face Vitreous Images
Purpose: To determine the topographic relationships and geographic distribution of prevascular vitreous fissures (PVFs) and cisterns across the entire posterior vitreous membrane in healthy subjects, using ultrawidefield en face and cross-sectional swept-source OCT (SS-OCT) images. Design: Observati...
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Elsevier
2025-03-01
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| Series: | Ophthalmology Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666914524001969 |
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| author | Fei Deng, MD Mengying Tao, MD Yanjie Zhu, MD Xiaoyu Xu, MD Yue Wu, MD Lisha Li Ying Lin, MD, PhD Yan Luo, MD, PhD |
| author_facet | Fei Deng, MD Mengying Tao, MD Yanjie Zhu, MD Xiaoyu Xu, MD Yue Wu, MD Lisha Li Ying Lin, MD, PhD Yan Luo, MD, PhD |
| author_sort | Fei Deng, MD |
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| description | Purpose: To determine the topographic relationships and geographic distribution of prevascular vitreous fissures (PVFs) and cisterns across the entire posterior vitreous membrane in healthy subjects, using ultrawidefield en face and cross-sectional swept-source OCT (SS-OCT) images. Design: Observational cross-sectional study. Participants: Ninety-six eyes of 96 healthy participants (age range, 20–49 years) without posterior vitreous detachment. Methods: For each eye, a 29 × 24-mm SS-OCT volume scan was obtained, along with standardized horizontal and vertical scans through the fovea. Main Outcome Measures: Ultrawidefield en face and cross-sectional images were analyzed to assess the topographic relationships and geographic distribution of PVFs and cisterns in the posterior vitreous. Results: En face imaging readily distinguished various preretinal liquefaction spaces throughout the posterior vitreous, extending to near the equator. Aside from the posterior precortical vitreous pocket (PPVP) and the area of Martegiani, all preretinal liquefied fissures and cisterns were distributed along superficial retinal vessels, suggesting they originated from prevascular vitreous liquefaction. In 96 eyes of healthy young and middle-aged adults, PVFs were identified in all participants, presenting a continuous course. Cisterns were detected in 79 eyes (82.3%) and were distributed as follows: superotemporal (91.1%), infratemporal (63.3%), supranasal (41.8%), and inferonasal (22.8%), respectively. The superotemporal cistern was most frequently observed (P < 0.001), and cisterns were more likely to involve multiple quadrants with age (P = 0.005). Additionally, all preretinal liquefaction spaces, including the PPVP, PVFs, and cisterns, were consistently located overlying the vitreoretinal tightly adhered regions. Conclusions: Ultrawidefield en face vitreous imaging in healthy young and middle-aged adults revealed that (1) PVFs distributed along superficial retinal vessels with continuous course; (2) cisterns may develop from PVFs and are more common in the superotemporal quadrant; (3) cisterns appear early in life and become more widespread with age; (4) preretinal vitreous liquefaction follows a stereotypic pattern, aligning along regions of firm vitreoretinal adhesion. Financial Disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article. |
| format | Article |
| id | doaj-art-a455baf1cd0942e799ac97124515a724 |
| institution | Kabale University |
| issn | 2666-9145 |
| language | English |
| publishDate | 2025-03-01 |
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| spelling | doaj-art-a455baf1cd0942e799ac97124515a7242025-01-23T05:27:51ZengElsevierOphthalmology Science2666-91452025-03-0152100660The Topographic Relationships and Geographic Distribution of Prevascular Vitreous Fissures and Cisterns Assessed by Ultrawidefield En Face Vitreous ImagesFei Deng, MD0Mengying Tao, MD1Yanjie Zhu, MD2Xiaoyu Xu, MD3Yue Wu, MD4Lisha Li5Ying Lin, MD, PhD6Yan Luo, MD, PhD7State Key Laboratory of Ophthalmology, Image Reading Center, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, ChinaState Key Laboratory of Ophthalmology, Image Reading Center, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, ChinaState Key Laboratory of Ophthalmology, Image Reading Center, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, ChinaState Key Laboratory of Ophthalmology, Image Reading Center, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, ChinaState Key Laboratory of Ophthalmology, Image Reading Center, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, ChinaState Key Laboratory of Ophthalmology, Image Reading Center, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, ChinaState Key Laboratory of Ophthalmology, Image Reading Center, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, ChinaCorrespondence: Yan Luo, MD, PhD, Department of Ocular Immunology and Uveitis, Zhongshan Ophthalmic Center, Sun Yat-Sen University, 54 Xianlie South Road, Yuexiu District, Guangzhou, 510060 China.; State Key Laboratory of Ophthalmology, Image Reading Center, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, ChinaPurpose: To determine the topographic relationships and geographic distribution of prevascular vitreous fissures (PVFs) and cisterns across the entire posterior vitreous membrane in healthy subjects, using ultrawidefield en face and cross-sectional swept-source OCT (SS-OCT) images. Design: Observational cross-sectional study. Participants: Ninety-six eyes of 96 healthy participants (age range, 20–49 years) without posterior vitreous detachment. Methods: For each eye, a 29 × 24-mm SS-OCT volume scan was obtained, along with standardized horizontal and vertical scans through the fovea. Main Outcome Measures: Ultrawidefield en face and cross-sectional images were analyzed to assess the topographic relationships and geographic distribution of PVFs and cisterns in the posterior vitreous. Results: En face imaging readily distinguished various preretinal liquefaction spaces throughout the posterior vitreous, extending to near the equator. Aside from the posterior precortical vitreous pocket (PPVP) and the area of Martegiani, all preretinal liquefied fissures and cisterns were distributed along superficial retinal vessels, suggesting they originated from prevascular vitreous liquefaction. In 96 eyes of healthy young and middle-aged adults, PVFs were identified in all participants, presenting a continuous course. Cisterns were detected in 79 eyes (82.3%) and were distributed as follows: superotemporal (91.1%), infratemporal (63.3%), supranasal (41.8%), and inferonasal (22.8%), respectively. The superotemporal cistern was most frequently observed (P < 0.001), and cisterns were more likely to involve multiple quadrants with age (P = 0.005). Additionally, all preretinal liquefaction spaces, including the PPVP, PVFs, and cisterns, were consistently located overlying the vitreoretinal tightly adhered regions. Conclusions: Ultrawidefield en face vitreous imaging in healthy young and middle-aged adults revealed that (1) PVFs distributed along superficial retinal vessels with continuous course; (2) cisterns may develop from PVFs and are more common in the superotemporal quadrant; (3) cisterns appear early in life and become more widespread with age; (4) preretinal vitreous liquefaction follows a stereotypic pattern, aligning along regions of firm vitreoretinal adhesion. Financial Disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.http://www.sciencedirect.com/science/article/pii/S2666914524001969CisternsEn face imagingPrevascular vitreous fissuresUltra-widefieldVitreous |
| spellingShingle | Fei Deng, MD Mengying Tao, MD Yanjie Zhu, MD Xiaoyu Xu, MD Yue Wu, MD Lisha Li Ying Lin, MD, PhD Yan Luo, MD, PhD The Topographic Relationships and Geographic Distribution of Prevascular Vitreous Fissures and Cisterns Assessed by Ultrawidefield En Face Vitreous Images Ophthalmology Science Cisterns En face imaging Prevascular vitreous fissures Ultra-widefield Vitreous |
| title | The Topographic Relationships and Geographic Distribution of Prevascular Vitreous Fissures and Cisterns Assessed by Ultrawidefield En Face Vitreous Images |
| title_full | The Topographic Relationships and Geographic Distribution of Prevascular Vitreous Fissures and Cisterns Assessed by Ultrawidefield En Face Vitreous Images |
| title_fullStr | The Topographic Relationships and Geographic Distribution of Prevascular Vitreous Fissures and Cisterns Assessed by Ultrawidefield En Face Vitreous Images |
| title_full_unstemmed | The Topographic Relationships and Geographic Distribution of Prevascular Vitreous Fissures and Cisterns Assessed by Ultrawidefield En Face Vitreous Images |
| title_short | The Topographic Relationships and Geographic Distribution of Prevascular Vitreous Fissures and Cisterns Assessed by Ultrawidefield En Face Vitreous Images |
| title_sort | topographic relationships and geographic distribution of prevascular vitreous fissures and cisterns assessed by ultrawidefield en face vitreous images |
| topic | Cisterns En face imaging Prevascular vitreous fissures Ultra-widefield Vitreous |
| url | http://www.sciencedirect.com/science/article/pii/S2666914524001969 |
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