In-Hospital Mortality among Ischemic Stroke Patients in Gondar University Hospital: A Retrospective Cohort Study
Introduction. Ischemic stroke is the third leading cause of mortality in low-income countries and the sixth in Ethiopia. The aim of this study was to determine the rate and predictors of in-hospital mortality due to ischemic stroke in Gondar University Hospital. Methods. The study was conducted from...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Stroke Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2019/7275063 |
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| author | Eyob Alemayehu Gebreyohannes Akshaya Srikanth Bhagavathula Tamrat Befekadu Abebe Mohammed Assen Seid Kaleab Taye Haile |
| author_facet | Eyob Alemayehu Gebreyohannes Akshaya Srikanth Bhagavathula Tamrat Befekadu Abebe Mohammed Assen Seid Kaleab Taye Haile |
| author_sort | Eyob Alemayehu Gebreyohannes |
| collection | DOAJ |
| description | Introduction. Ischemic stroke is the third leading cause of mortality in low-income countries and the sixth in Ethiopia. The aim of this study was to determine the rate and predictors of in-hospital mortality due to ischemic stroke in Gondar University Hospital. Methods. The study was conducted from April 1, 2017, to May 15, 2017, at Gondar University Hospital. A census using retrospective cohort study design was conducted on medical records of adult patients with the diagnosis of ischemic stroke attending the medical inpatient ward of Gondar University Hospital between November 2012 and September 2016. Cox hazard regression was used to determine the predictors of in-hospital mortality. A two-sided statistical test at 5% level of significance was used. Results. The mean (±SD) duration of hospital stay was 11.55 (10.040) days. Of the total 208 patients, 26 (12.5%) patients died in the hospital. Cox regression revealed that only a decrease in renal function, particularly elevated serum creatinine (AHR=8.848, 95% CI: 1.616-67.437), was associated with a statistically significant increase of in-hospital mortality. The symptom onset-to-admission time varied greatly among patients and ranged from 1 hour to 168 hours. Conclusion. The in-hospital mortality associated with ischemic stroke was found to be high. Mainly, elevation in serum creatinine was highly associated with poorer outcomes in terms of in-hospital mortality. Much work should be done on improving the knowledge and awareness of the community regarding ischemic stroke and stroke in general to encourage early medical seeking behavior and reduce mortality and long-term disability. |
| format | Article |
| id | doaj-art-a44cc14028a54977aaffc906b081079c |
| institution | Kabale University |
| issn | 2090-8105 2042-0056 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stroke Research and Treatment |
| spelling | doaj-art-a44cc14028a54977aaffc906b081079c2025-02-03T06:46:13ZengWileyStroke Research and Treatment2090-81052042-00562019-01-01201910.1155/2019/72750637275063In-Hospital Mortality among Ischemic Stroke Patients in Gondar University Hospital: A Retrospective Cohort StudyEyob Alemayehu Gebreyohannes0Akshaya Srikanth Bhagavathula1Tamrat Befekadu Abebe2Mohammed Assen Seid3Kaleab Taye Haile4Department of Clinical Pharmacy, University of Gondar, Gondar, EthiopiaDepartment of Clinical Pharmacy, University of Gondar, Gondar, EthiopiaDepartment of Clinical Pharmacy, University of Gondar, Gondar, EthiopiaDepartment of Clinical Pharmacy, University of Gondar, Gondar, EthiopiaDepartment of Pharmaceutics, University of Gondar, Gondar, EthiopiaIntroduction. Ischemic stroke is the third leading cause of mortality in low-income countries and the sixth in Ethiopia. The aim of this study was to determine the rate and predictors of in-hospital mortality due to ischemic stroke in Gondar University Hospital. Methods. The study was conducted from April 1, 2017, to May 15, 2017, at Gondar University Hospital. A census using retrospective cohort study design was conducted on medical records of adult patients with the diagnosis of ischemic stroke attending the medical inpatient ward of Gondar University Hospital between November 2012 and September 2016. Cox hazard regression was used to determine the predictors of in-hospital mortality. A two-sided statistical test at 5% level of significance was used. Results. The mean (±SD) duration of hospital stay was 11.55 (10.040) days. Of the total 208 patients, 26 (12.5%) patients died in the hospital. Cox regression revealed that only a decrease in renal function, particularly elevated serum creatinine (AHR=8.848, 95% CI: 1.616-67.437), was associated with a statistically significant increase of in-hospital mortality. The symptom onset-to-admission time varied greatly among patients and ranged from 1 hour to 168 hours. Conclusion. The in-hospital mortality associated with ischemic stroke was found to be high. Mainly, elevation in serum creatinine was highly associated with poorer outcomes in terms of in-hospital mortality. Much work should be done on improving the knowledge and awareness of the community regarding ischemic stroke and stroke in general to encourage early medical seeking behavior and reduce mortality and long-term disability.http://dx.doi.org/10.1155/2019/7275063 |
| spellingShingle | Eyob Alemayehu Gebreyohannes Akshaya Srikanth Bhagavathula Tamrat Befekadu Abebe Mohammed Assen Seid Kaleab Taye Haile In-Hospital Mortality among Ischemic Stroke Patients in Gondar University Hospital: A Retrospective Cohort Study Stroke Research and Treatment |
| title | In-Hospital Mortality among Ischemic Stroke Patients in Gondar University Hospital: A Retrospective Cohort Study |
| title_full | In-Hospital Mortality among Ischemic Stroke Patients in Gondar University Hospital: A Retrospective Cohort Study |
| title_fullStr | In-Hospital Mortality among Ischemic Stroke Patients in Gondar University Hospital: A Retrospective Cohort Study |
| title_full_unstemmed | In-Hospital Mortality among Ischemic Stroke Patients in Gondar University Hospital: A Retrospective Cohort Study |
| title_short | In-Hospital Mortality among Ischemic Stroke Patients in Gondar University Hospital: A Retrospective Cohort Study |
| title_sort | in hospital mortality among ischemic stroke patients in gondar university hospital a retrospective cohort study |
| url | http://dx.doi.org/10.1155/2019/7275063 |
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