Phase-transition engineered semi-metallic Cu3PdN for photothermal-enhanced cuproptosis-induced cancer therapy
In-situ activation of cuproptosis shows considerable promise in cancer therapy. However, its efficacy is often hindered by the accumulation of copper ions and limitations of the activation strategy. Herein, a novel copper-palladium nitride (Cu3PdN)-modified injectable hydrogel with enhanced photothe...
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| Language: | English |
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Elsevier
2025-06-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425004971 |
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| author | Yao Gao Guangru Li Shuoxun Chen Weijie Yu Shuanglong Yi Yu Chen Luodan Yu |
| author_facet | Yao Gao Guangru Li Shuoxun Chen Weijie Yu Shuanglong Yi Yu Chen Luodan Yu |
| author_sort | Yao Gao |
| collection | DOAJ |
| description | In-situ activation of cuproptosis shows considerable promise in cancer therapy. However, its efficacy is often hindered by the accumulation of copper ions and limitations of the activation strategy. Herein, a novel copper-palladium nitride (Cu3PdN)-modified injectable hydrogel with enhanced photothermal conversion efficiency was designed to improve copper accumulation at tumor sites and achieve photothermia-enhanced cuproptosis. A phase transition from Cu3N to Pd-doped Cu3PdN was achieved, transforming the material from a semiconductor to a semi-metal with a reduced band gap. This modification endowed Cu3PdN with full-spectrum absorption and enhanced photothermal conversion efficiency. Coupled with the abundant copper content, Cu3PdN nanoparticles hold great potential for photothermal-enhanced, in-situ cuproptosis-based cancer therapy. The Cu3PdN system demonstrates stimulus-responsive Cu(I) ions release and Fenton-like activity, promoting the generation of reactive oxygen species, mitochondrial dysfunction, and the oligomerization of dihydrolipoamide S-acetyltransferase, which together trigger cuproptosis. Overall, this study provides a promising approach for utilizing metal nitrides to induce photothermal-enhanced cuproptosis in tumor therapy. |
| format | Article |
| id | doaj-art-a43f53334e2c433b96e9b7267e3837f5 |
| institution | OA Journals |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-a43f53334e2c433b96e9b7267e3837f52025-08-20T02:02:19ZengElsevierMaterials Today Bio2590-00642025-06-013210192710.1016/j.mtbio.2025.101927Phase-transition engineered semi-metallic Cu3PdN for photothermal-enhanced cuproptosis-induced cancer therapyYao Gao0Guangru Li1Shuoxun Chen2Weijie Yu3Shuanglong Yi4Yu Chen5Luodan Yu6Materdicine Lab, School of Life Sciences, Shanghai University, Shanghai, 200444, PR ChinaMaterdicine Lab, School of Life Sciences, Shanghai University, Shanghai, 200444, PR ChinaMaterdicine Lab, School of Life Sciences, Shanghai University, Shanghai, 200444, PR ChinaMaterdicine Lab, School of Life Sciences, Shanghai University, Shanghai, 200444, PR ChinaDepartment of Radiology, Shanghai Institute of Thoracic Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, PR China; Corresponding author.Materdicine Lab, School of Life Sciences, Shanghai University, Shanghai, 200444, PR China; Corresponding author.Department of Radiology, Shanghai Institute of Thoracic Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, PR China; Corresponding author.In-situ activation of cuproptosis shows considerable promise in cancer therapy. However, its efficacy is often hindered by the accumulation of copper ions and limitations of the activation strategy. Herein, a novel copper-palladium nitride (Cu3PdN)-modified injectable hydrogel with enhanced photothermal conversion efficiency was designed to improve copper accumulation at tumor sites and achieve photothermia-enhanced cuproptosis. A phase transition from Cu3N to Pd-doped Cu3PdN was achieved, transforming the material from a semiconductor to a semi-metal with a reduced band gap. This modification endowed Cu3PdN with full-spectrum absorption and enhanced photothermal conversion efficiency. Coupled with the abundant copper content, Cu3PdN nanoparticles hold great potential for photothermal-enhanced, in-situ cuproptosis-based cancer therapy. The Cu3PdN system demonstrates stimulus-responsive Cu(I) ions release and Fenton-like activity, promoting the generation of reactive oxygen species, mitochondrial dysfunction, and the oligomerization of dihydrolipoamide S-acetyltransferase, which together trigger cuproptosis. Overall, this study provides a promising approach for utilizing metal nitrides to induce photothermal-enhanced cuproptosis in tumor therapy.http://www.sciencedirect.com/science/article/pii/S2590006425004971CuproptosisMetal nitridesPhotothermal materialsTumor therapy |
| spellingShingle | Yao Gao Guangru Li Shuoxun Chen Weijie Yu Shuanglong Yi Yu Chen Luodan Yu Phase-transition engineered semi-metallic Cu3PdN for photothermal-enhanced cuproptosis-induced cancer therapy Materials Today Bio Cuproptosis Metal nitrides Photothermal materials Tumor therapy |
| title | Phase-transition engineered semi-metallic Cu3PdN for photothermal-enhanced cuproptosis-induced cancer therapy |
| title_full | Phase-transition engineered semi-metallic Cu3PdN for photothermal-enhanced cuproptosis-induced cancer therapy |
| title_fullStr | Phase-transition engineered semi-metallic Cu3PdN for photothermal-enhanced cuproptosis-induced cancer therapy |
| title_full_unstemmed | Phase-transition engineered semi-metallic Cu3PdN for photothermal-enhanced cuproptosis-induced cancer therapy |
| title_short | Phase-transition engineered semi-metallic Cu3PdN for photothermal-enhanced cuproptosis-induced cancer therapy |
| title_sort | phase transition engineered semi metallic cu3pdn for photothermal enhanced cuproptosis induced cancer therapy |
| topic | Cuproptosis Metal nitrides Photothermal materials Tumor therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425004971 |
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