Elevated Anthropometric and Metabolic Indicators among Young Adult Offspring of Mothers with Pregestational Diabetes: Early Results from the Transgenerational Effect on Adult Morbidity Study (the TEAM Study)
Exposure to maternal diabetes in utero increases the risk in the offspring for a range of metabolic disturbances. However, the timing and variability of in utero hyperglycemic exposure necessary to cause impairment have not been elucidated. The TEAM Study was initiated to evaluate young adult offspr...
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| Format: | Article |
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2021-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2021/6590431 |
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| author | Katherine Bowers Shelley Ehrlich Lawrence M. Dolan Resmi Gupta Mekibib Altaye Nicholas J. Ollberding Rhonda Szczesniak Patrick Catalano Emily Smith Jane C. Khoury |
| author_facet | Katherine Bowers Shelley Ehrlich Lawrence M. Dolan Resmi Gupta Mekibib Altaye Nicholas J. Ollberding Rhonda Szczesniak Patrick Catalano Emily Smith Jane C. Khoury |
| author_sort | Katherine Bowers |
| collection | DOAJ |
| description | Exposure to maternal diabetes in utero increases the risk in the offspring for a range of metabolic disturbances. However, the timing and variability of in utero hyperglycemic exposure necessary to cause impairment have not been elucidated. The TEAM Study was initiated to evaluate young adult offspring of mothers with pregestational diabetes mellitus. This paper outlines the unique enrollment challenges of the TEAM Study and preliminary analysis of the association between exposure to diabetes in pregnancy and adverse metabolic outcomes. The TEAM Study enrolls offspring of women who participated in a Diabetes in Pregnancy (DiP) Program Project Grant between 1978 and 1995. The DiP Study collected medical and obstetric data across pregnancy. The first 96 eligible offspring of women with pregestational diabetes were age-, sex-, and race-matched to adults from the National Health and Nutrition Examination Survey (NHANES) 2015-2016 with an OGTT. Descriptive and regression analyses were employed to compare TEAM participants to NHANES participants. Among a subset of TEAM participants, we compared the metabolic outcomes across maternal glucose profiles using a longitudinal data clustering technique that characterizes level and variability, in maternal glucose across pregnancy. By comparing categories of BMI, TEAM Study participants had over 2.0 times the odds of being obese compared to matched NHANES participants (for class III obesity, OR=2.81; 95% confidence interval (CI): 1.15, 6.87). Increasing levels of two-hour glucose were also associated with in utero exposure to pregestational diabetes in matched analyses. Exposure to pregestational diabetes in utero may be associated with an increased risk of metabolic impairment in the offspring with clinical implications. |
| format | Article |
| id | doaj-art-a42b69f887ff4a9cb6a87da25265227f |
| institution | Kabale University |
| issn | 2314-6753 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-a42b69f887ff4a9cb6a87da25265227f2025-02-03T06:06:55ZengWileyJournal of Diabetes Research2314-67532021-01-01202110.1155/2021/6590431Elevated Anthropometric and Metabolic Indicators among Young Adult Offspring of Mothers with Pregestational Diabetes: Early Results from the Transgenerational Effect on Adult Morbidity Study (the TEAM Study)Katherine Bowers0Shelley Ehrlich1Lawrence M. Dolan2Resmi Gupta3Mekibib Altaye4Nicholas J. Ollberding5Rhonda Szczesniak6Patrick Catalano7Emily Smith8Jane C. Khoury9Division of Biostatistics and EpidemiologyDivision of Biostatistics and EpidemiologyUniversity of Cincinnati College of MedicineBiostatistics and Epidemiology/Research Design ComponentDivision of Biostatistics and EpidemiologyDivision of Biostatistics and EpidemiologyDivision of Biostatistics and EpidemiologyTufts University School of MedicineDivision of EndocrinologyDivision of Biostatistics and EpidemiologyExposure to maternal diabetes in utero increases the risk in the offspring for a range of metabolic disturbances. However, the timing and variability of in utero hyperglycemic exposure necessary to cause impairment have not been elucidated. The TEAM Study was initiated to evaluate young adult offspring of mothers with pregestational diabetes mellitus. This paper outlines the unique enrollment challenges of the TEAM Study and preliminary analysis of the association between exposure to diabetes in pregnancy and adverse metabolic outcomes. The TEAM Study enrolls offspring of women who participated in a Diabetes in Pregnancy (DiP) Program Project Grant between 1978 and 1995. The DiP Study collected medical and obstetric data across pregnancy. The first 96 eligible offspring of women with pregestational diabetes were age-, sex-, and race-matched to adults from the National Health and Nutrition Examination Survey (NHANES) 2015-2016 with an OGTT. Descriptive and regression analyses were employed to compare TEAM participants to NHANES participants. Among a subset of TEAM participants, we compared the metabolic outcomes across maternal glucose profiles using a longitudinal data clustering technique that characterizes level and variability, in maternal glucose across pregnancy. By comparing categories of BMI, TEAM Study participants had over 2.0 times the odds of being obese compared to matched NHANES participants (for class III obesity, OR=2.81; 95% confidence interval (CI): 1.15, 6.87). Increasing levels of two-hour glucose were also associated with in utero exposure to pregestational diabetes in matched analyses. Exposure to pregestational diabetes in utero may be associated with an increased risk of metabolic impairment in the offspring with clinical implications.http://dx.doi.org/10.1155/2021/6590431 |
| spellingShingle | Katherine Bowers Shelley Ehrlich Lawrence M. Dolan Resmi Gupta Mekibib Altaye Nicholas J. Ollberding Rhonda Szczesniak Patrick Catalano Emily Smith Jane C. Khoury Elevated Anthropometric and Metabolic Indicators among Young Adult Offspring of Mothers with Pregestational Diabetes: Early Results from the Transgenerational Effect on Adult Morbidity Study (the TEAM Study) Journal of Diabetes Research |
| title | Elevated Anthropometric and Metabolic Indicators among Young Adult Offspring of Mothers with Pregestational Diabetes: Early Results from the Transgenerational Effect on Adult Morbidity Study (the TEAM Study) |
| title_full | Elevated Anthropometric and Metabolic Indicators among Young Adult Offspring of Mothers with Pregestational Diabetes: Early Results from the Transgenerational Effect on Adult Morbidity Study (the TEAM Study) |
| title_fullStr | Elevated Anthropometric and Metabolic Indicators among Young Adult Offspring of Mothers with Pregestational Diabetes: Early Results from the Transgenerational Effect on Adult Morbidity Study (the TEAM Study) |
| title_full_unstemmed | Elevated Anthropometric and Metabolic Indicators among Young Adult Offspring of Mothers with Pregestational Diabetes: Early Results from the Transgenerational Effect on Adult Morbidity Study (the TEAM Study) |
| title_short | Elevated Anthropometric and Metabolic Indicators among Young Adult Offspring of Mothers with Pregestational Diabetes: Early Results from the Transgenerational Effect on Adult Morbidity Study (the TEAM Study) |
| title_sort | elevated anthropometric and metabolic indicators among young adult offspring of mothers with pregestational diabetes early results from the transgenerational effect on adult morbidity study the team study |
| url | http://dx.doi.org/10.1155/2021/6590431 |
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