Comparing the Efficacy of Excitatory Transcranial Stimulation Methods Measuring Motor Evoked Potentials
The common aim of transcranial stimulation methods is the induction or alterations of cortical excitability in a controlled way. Significant effects of each individual stimulation method have been published; however, conclusive direct comparisons of many of these methods are rare. The aim of the pre...
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Wiley
2014-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2014/837141 |
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| author | Vera Moliadze Georg Fritzsche Andrea Antal |
| author_facet | Vera Moliadze Georg Fritzsche Andrea Antal |
| author_sort | Vera Moliadze |
| collection | DOAJ |
| description | The common aim of transcranial stimulation methods is the induction or alterations of cortical excitability in a controlled way. Significant effects of each individual stimulation method have been published; however, conclusive direct comparisons of many of these methods are rare. The aim of the present study was to compare the efficacy of three widely applied stimulation methods inducing excitability enhancement in the motor cortex: 1 mA anodal transcranial direct current stimulation (atDCS), intermittent theta burst stimulation (iTBS), and 1 mA transcranial random noise stimulation (tRNS) within one subject group. The effect of each stimulation condition was quantified by evaluating motor-evoked-potential amplitudes (MEPs) in a fixed time sequence after stimulation. The analyses confirmed a significant enhancement of the M1 excitability caused by all three types of active stimulations compared to sham stimulation. There was no significant difference between the types of active stimulations, although the time course of the excitatory effects slightly differed. Among the stimulation methods, tRNS resulted in the strongest and atDCS significantly longest MEP increase compared to sham. Different time courses of the applied stimulation methods suggest different underlying mechanisms of action. Better understanding may be useful for better targeting of different transcranial stimulation techniques. |
| format | Article |
| id | doaj-art-a4197c932aa044eaae789abe8549cf6c |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
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| series | Neural Plasticity |
| spelling | doaj-art-a4197c932aa044eaae789abe8549cf6c2025-02-03T05:53:48ZengWileyNeural Plasticity2090-59041687-54432014-01-01201410.1155/2014/837141837141Comparing the Efficacy of Excitatory Transcranial Stimulation Methods Measuring Motor Evoked PotentialsVera Moliadze0Georg Fritzsche1Andrea Antal2Department of Clinical Neurophysiology, University Medical Center, Georg-August University of Göttingen, Robert-Koch-Straße 40, 37075 Göttingen, GermanyDepartment of Clinical Neurophysiology, University Medical Center, Georg-August University of Göttingen, Robert-Koch-Straße 40, 37075 Göttingen, GermanyDepartment of Clinical Neurophysiology, University Medical Center, Georg-August University of Göttingen, Robert-Koch-Straße 40, 37075 Göttingen, GermanyThe common aim of transcranial stimulation methods is the induction or alterations of cortical excitability in a controlled way. Significant effects of each individual stimulation method have been published; however, conclusive direct comparisons of many of these methods are rare. The aim of the present study was to compare the efficacy of three widely applied stimulation methods inducing excitability enhancement in the motor cortex: 1 mA anodal transcranial direct current stimulation (atDCS), intermittent theta burst stimulation (iTBS), and 1 mA transcranial random noise stimulation (tRNS) within one subject group. The effect of each stimulation condition was quantified by evaluating motor-evoked-potential amplitudes (MEPs) in a fixed time sequence after stimulation. The analyses confirmed a significant enhancement of the M1 excitability caused by all three types of active stimulations compared to sham stimulation. There was no significant difference between the types of active stimulations, although the time course of the excitatory effects slightly differed. Among the stimulation methods, tRNS resulted in the strongest and atDCS significantly longest MEP increase compared to sham. Different time courses of the applied stimulation methods suggest different underlying mechanisms of action. Better understanding may be useful for better targeting of different transcranial stimulation techniques.http://dx.doi.org/10.1155/2014/837141 |
| spellingShingle | Vera Moliadze Georg Fritzsche Andrea Antal Comparing the Efficacy of Excitatory Transcranial Stimulation Methods Measuring Motor Evoked Potentials Neural Plasticity |
| title | Comparing the Efficacy of Excitatory Transcranial Stimulation Methods Measuring Motor Evoked Potentials |
| title_full | Comparing the Efficacy of Excitatory Transcranial Stimulation Methods Measuring Motor Evoked Potentials |
| title_fullStr | Comparing the Efficacy of Excitatory Transcranial Stimulation Methods Measuring Motor Evoked Potentials |
| title_full_unstemmed | Comparing the Efficacy of Excitatory Transcranial Stimulation Methods Measuring Motor Evoked Potentials |
| title_short | Comparing the Efficacy of Excitatory Transcranial Stimulation Methods Measuring Motor Evoked Potentials |
| title_sort | comparing the efficacy of excitatory transcranial stimulation methods measuring motor evoked potentials |
| url | http://dx.doi.org/10.1155/2014/837141 |
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