Periplocin potentiates ferroptotic cell death in non-small cell lung cancer by inducing the degradation of Nrf2

Periplocin potentiates ferroptotic cell death in non-small cell lung cancer by inducing the degradation of Nrf2

Abstract Background Non-small cell lung cancer represents the main histological subtype of lung cancer. Periplocin is a major cardiac glycoside found in the traditional Chinese medicine Cortex periplocae administered in cardiovascular and autoimmune diseases. Inspired by recent findings reporting th...

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Bibliographic Details
Main Authors: Jinhao Wang, Yue Zhu, Jialiang Song, Fengping Yang, Peng Wang, Ziyi Zhang, Yuxuan Li, Minghe Dai, Yinuo Wang, Waleed Yousuf, Jiayu Li, Dian Yang, Shaoxuan Cheng, Shuyan Liu, Zhaoxia Dai, Xun Qiu, Yingqiu Zhang, Zengchun Hu
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Cancer Cell International
Subjects:
Non-small cell lung cancer
Periplocin
Ferroptosis
Transcriptomic profiling
Nrf2
Proteasomal degradation
Online Access:https://doi.org/10.1186/s12935-025-03925-5
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