PRMT6 Epigenetically Drives Metabolic Switch from Fatty Acid Oxidation toward Glycolysis and Promotes Osteoclast Differentiation During Osteoporosis

PRMT6 Epigenetically Drives Metabolic Switch from Fatty Acid Oxidation toward Glycolysis and Promotes Osteoclast Differentiation During Osteoporosis

Abstract Epigenetic regulation of metabolism profoundly influences cell fate commitment. During osteoclast differentiation, the activation of RANK signaling is accompanied by metabolic reprogramming, but the epigenetic mechanisms by which RANK signaling induces this reprogramming remain elusive. By...

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Main Authors: Wenxiang Chu, Weilin Peng, Yingying Lu, Yishan Liu, Qisheng Li, Haibin Wang, Liang Wang, Bangke Zhang, Zhixiao Liu, Lin Han, Hongdao Ma, Haisong Yang, Chaofeng Han, Xuhua Lu
Format: Article
Language:English
Published: Wiley 2024-10-01
Series:Advanced Science
Subjects:
fatty acids oxidation
glycolysis
metabolic reprogramming
osteoclastogenesis
PRMT6
Online Access:https://doi.org/10.1002/advs.202403177
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