In-silico approaches to unravel the efficacy of naturally occurring C–C and C–O–C type biflavonoids towards the inhibition of MDM2–p53 interactions
Abstract The p53 protein is essential for controlling the cell cycle and promoting apoptosis, which are critical processes in preventing tumor development. MDM2 acts as a negative regulator of p53 by facilitating its degradation, thereby diminishing its ability to suppress tumors. In the present stu...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer
2025-04-01
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| Series: | Discover Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s44371-025-00167-2 |
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