A New Metabolism-Related Index Correlates with the Degree of Liver Fibrosis in Hepatitis C Virus-Positive Patients
Background. Only a few biomarkers based on metabolic parameters for evaluating liver fibrosis have been reported. The aim of this study was to investigate the relevance of an index obtained from three metabolic variables (glycated albumin: GA, glycated hemoglobin: HbA1c, and branched-chain amino aci...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2015/926169 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832551328864272384 |
|---|---|
| author | Hirayuki Enomoto Nobuhiro Aizawa Hideji Nakamura Ryo Takata Yoshiyuki Sakai Yoshinori Iwata Hironori Tanaka Naoto Ikeda Tomoko Aoki Kunihiro Hasegawa Kazunori Yoh Kenji Hashimoto Akio Ishii Tomoyuki Takashima Masaki Saito Hiroyasu Imanishi Hiroko Iijima Shuhei Nishiguchi |
| author_facet | Hirayuki Enomoto Nobuhiro Aizawa Hideji Nakamura Ryo Takata Yoshiyuki Sakai Yoshinori Iwata Hironori Tanaka Naoto Ikeda Tomoko Aoki Kunihiro Hasegawa Kazunori Yoh Kenji Hashimoto Akio Ishii Tomoyuki Takashima Masaki Saito Hiroyasu Imanishi Hiroko Iijima Shuhei Nishiguchi |
| author_sort | Hirayuki Enomoto |
| collection | DOAJ |
| description | Background. Only a few biomarkers based on metabolic parameters for evaluating liver fibrosis have been reported. The aim of this study was to investigate the relevance of an index obtained from three metabolic variables (glycated albumin: GA, glycated hemoglobin: HbA1c, and branched-chain amino acids to tyrosine ratio: BTR) to the degree of liver fibrosis in hepatitis C virus virus- (HCV-) positive patients. Methods. A total of 394 HCV-positive patients were assessed based on the values of a new index (GA/HbA1c/BTR). The index findings were used to investigate the relationship with the degree of liver fibrosis. Results. The new index showed an association with the stage of fibrosis (METAVIR scores: F0-1: 0.42 ± 0.10, F2: 0.48 ± 0.15, F3: 0.56 ± 0.22, and F4: 0.71 ± 0.30). The index was negatively correlated with three variables of liver function: the prothrombin time percentage (P<0.0001), albumin level (P<0.0001), and cholinesterase level (P<0.0001). The new index showed a higher correlation related to liver function than FIB-4 and the APRI did. In addition, the index showed a higher AUROC value than that of FIB-4 and the APRI for prediction of liver cirrhosis. Conclusion. The new metabolism-related index, GA/HbA1c/BTR value, is shown to relate to the degree of liver fibrosis in HCV-positive patients. |
| format | Article |
| id | doaj-art-a401efe5c20544879b402173c0940b21 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-a401efe5c20544879b402173c0940b212025-02-03T06:01:45ZengWileyGastroenterology Research and Practice1687-61211687-630X2015-01-01201510.1155/2015/926169926169A New Metabolism-Related Index Correlates with the Degree of Liver Fibrosis in Hepatitis C Virus-Positive PatientsHirayuki Enomoto0Nobuhiro Aizawa1Hideji Nakamura2Ryo Takata3Yoshiyuki Sakai4Yoshinori Iwata5Hironori Tanaka6Naoto Ikeda7Tomoko Aoki8Kunihiro Hasegawa9Kazunori Yoh10Kenji Hashimoto11Akio Ishii12Tomoyuki Takashima13Masaki Saito14Hiroyasu Imanishi15Hiroko Iijima16Shuhei Nishiguchi17Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo 663-8501, JapanDivision of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo 663-8501, JapanDepartment of Gastroenterology and Hepatology, Nissay Hospital, Itachibori 6-3-8, Nishi-ku, Osaka 550-0012, JapanDivision of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo 663-8501, JapanDivision of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo 663-8501, JapanDivision of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo 663-8501, JapanDivision of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo 663-8501, JapanDivision of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo 663-8501, JapanDivision of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo 663-8501, JapanDivision of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo 663-8501, JapanDivision of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo 663-8501, JapanDivision of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo 663-8501, JapanDivision of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo 663-8501, JapanDivision of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo 663-8501, JapanDivision of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo 663-8501, JapanDivision of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo 663-8501, JapanDivision of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo 663-8501, JapanDivision of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo 663-8501, JapanBackground. Only a few biomarkers based on metabolic parameters for evaluating liver fibrosis have been reported. The aim of this study was to investigate the relevance of an index obtained from three metabolic variables (glycated albumin: GA, glycated hemoglobin: HbA1c, and branched-chain amino acids to tyrosine ratio: BTR) to the degree of liver fibrosis in hepatitis C virus virus- (HCV-) positive patients. Methods. A total of 394 HCV-positive patients were assessed based on the values of a new index (GA/HbA1c/BTR). The index findings were used to investigate the relationship with the degree of liver fibrosis. Results. The new index showed an association with the stage of fibrosis (METAVIR scores: F0-1: 0.42 ± 0.10, F2: 0.48 ± 0.15, F3: 0.56 ± 0.22, and F4: 0.71 ± 0.30). The index was negatively correlated with three variables of liver function: the prothrombin time percentage (P<0.0001), albumin level (P<0.0001), and cholinesterase level (P<0.0001). The new index showed a higher correlation related to liver function than FIB-4 and the APRI did. In addition, the index showed a higher AUROC value than that of FIB-4 and the APRI for prediction of liver cirrhosis. Conclusion. The new metabolism-related index, GA/HbA1c/BTR value, is shown to relate to the degree of liver fibrosis in HCV-positive patients.http://dx.doi.org/10.1155/2015/926169 |
| spellingShingle | Hirayuki Enomoto Nobuhiro Aizawa Hideji Nakamura Ryo Takata Yoshiyuki Sakai Yoshinori Iwata Hironori Tanaka Naoto Ikeda Tomoko Aoki Kunihiro Hasegawa Kazunori Yoh Kenji Hashimoto Akio Ishii Tomoyuki Takashima Masaki Saito Hiroyasu Imanishi Hiroko Iijima Shuhei Nishiguchi A New Metabolism-Related Index Correlates with the Degree of Liver Fibrosis in Hepatitis C Virus-Positive Patients Gastroenterology Research and Practice |
| title | A New Metabolism-Related Index Correlates with the Degree of Liver Fibrosis in Hepatitis C Virus-Positive Patients |
| title_full | A New Metabolism-Related Index Correlates with the Degree of Liver Fibrosis in Hepatitis C Virus-Positive Patients |
| title_fullStr | A New Metabolism-Related Index Correlates with the Degree of Liver Fibrosis in Hepatitis C Virus-Positive Patients |
| title_full_unstemmed | A New Metabolism-Related Index Correlates with the Degree of Liver Fibrosis in Hepatitis C Virus-Positive Patients |
| title_short | A New Metabolism-Related Index Correlates with the Degree of Liver Fibrosis in Hepatitis C Virus-Positive Patients |
| title_sort | new metabolism related index correlates with the degree of liver fibrosis in hepatitis c virus positive patients |
| url | http://dx.doi.org/10.1155/2015/926169 |
| work_keys_str_mv | AT hirayukienomoto anewmetabolismrelatedindexcorrelateswiththedegreeofliverfibrosisinhepatitiscviruspositivepatients AT nobuhiroaizawa anewmetabolismrelatedindexcorrelateswiththedegreeofliverfibrosisinhepatitiscviruspositivepatients AT hidejinakamura anewmetabolismrelatedindexcorrelateswiththedegreeofliverfibrosisinhepatitiscviruspositivepatients AT ryotakata anewmetabolismrelatedindexcorrelateswiththedegreeofliverfibrosisinhepatitiscviruspositivepatients AT yoshiyukisakai anewmetabolismrelatedindexcorrelateswiththedegreeofliverfibrosisinhepatitiscviruspositivepatients AT yoshinoriiwata anewmetabolismrelatedindexcorrelateswiththedegreeofliverfibrosisinhepatitiscviruspositivepatients AT hironoritanaka anewmetabolismrelatedindexcorrelateswiththedegreeofliverfibrosisinhepatitiscviruspositivepatients AT naotoikeda anewmetabolismrelatedindexcorrelateswiththedegreeofliverfibrosisinhepatitiscviruspositivepatients AT tomokoaoki anewmetabolismrelatedindexcorrelateswiththedegreeofliverfibrosisinhepatitiscviruspositivepatients AT kunihirohasegawa anewmetabolismrelatedindexcorrelateswiththedegreeofliverfibrosisinhepatitiscviruspositivepatients AT kazunoriyoh anewmetabolismrelatedindexcorrelateswiththedegreeofliverfibrosisinhepatitiscviruspositivepatients AT kenjihashimoto anewmetabolismrelatedindexcorrelateswiththedegreeofliverfibrosisinhepatitiscviruspositivepatients AT akioishii anewmetabolismrelatedindexcorrelateswiththedegreeofliverfibrosisinhepatitiscviruspositivepatients AT tomoyukitakashima anewmetabolismrelatedindexcorrelateswiththedegreeofliverfibrosisinhepatitiscviruspositivepatients AT masakisaito anewmetabolismrelatedindexcorrelateswiththedegreeofliverfibrosisinhepatitiscviruspositivepatients AT hiroyasuimanishi anewmetabolismrelatedindexcorrelateswiththedegreeofliverfibrosisinhepatitiscviruspositivepatients AT hirokoiijima anewmetabolismrelatedindexcorrelateswiththedegreeofliverfibrosisinhepatitiscviruspositivepatients AT shuheinishiguchi anewmetabolismrelatedindexcorrelateswiththedegreeofliverfibrosisinhepatitiscviruspositivepatients AT hirayukienomoto newmetabolismrelatedindexcorrelateswiththedegreeofliverfibrosisinhepatitiscviruspositivepatients AT nobuhiroaizawa newmetabolismrelatedindexcorrelateswiththedegreeofliverfibrosisinhepatitiscviruspositivepatients AT hidejinakamura newmetabolismrelatedindexcorrelateswiththedegreeofliverfibrosisinhepatitiscviruspositivepatients AT ryotakata newmetabolismrelatedindexcorrelateswiththedegreeofliverfibrosisinhepatitiscviruspositivepatients AT yoshiyukisakai newmetabolismrelatedindexcorrelateswiththedegreeofliverfibrosisinhepatitiscviruspositivepatients AT yoshinoriiwata newmetabolismrelatedindexcorrelateswiththedegreeofliverfibrosisinhepatitiscviruspositivepatients AT hironoritanaka newmetabolismrelatedindexcorrelateswiththedegreeofliverfibrosisinhepatitiscviruspositivepatients AT naotoikeda newmetabolismrelatedindexcorrelateswiththedegreeofliverfibrosisinhepatitiscviruspositivepatients AT tomokoaoki newmetabolismrelatedindexcorrelateswiththedegreeofliverfibrosisinhepatitiscviruspositivepatients AT kunihirohasegawa newmetabolismrelatedindexcorrelateswiththedegreeofliverfibrosisinhepatitiscviruspositivepatients AT kazunoriyoh newmetabolismrelatedindexcorrelateswiththedegreeofliverfibrosisinhepatitiscviruspositivepatients AT kenjihashimoto newmetabolismrelatedindexcorrelateswiththedegreeofliverfibrosisinhepatitiscviruspositivepatients AT akioishii newmetabolismrelatedindexcorrelateswiththedegreeofliverfibrosisinhepatitiscviruspositivepatients AT tomoyukitakashima newmetabolismrelatedindexcorrelateswiththedegreeofliverfibrosisinhepatitiscviruspositivepatients AT masakisaito newmetabolismrelatedindexcorrelateswiththedegreeofliverfibrosisinhepatitiscviruspositivepatients AT hiroyasuimanishi newmetabolismrelatedindexcorrelateswiththedegreeofliverfibrosisinhepatitiscviruspositivepatients AT hirokoiijima newmetabolismrelatedindexcorrelateswiththedegreeofliverfibrosisinhepatitiscviruspositivepatients AT shuheinishiguchi newmetabolismrelatedindexcorrelateswiththedegreeofliverfibrosisinhepatitiscviruspositivepatients |