Prognostic Factors of Liposarcoma in Head and Neck
ObjectiveTo explore the pathogenesis and prognostic factors of liposarcoma in the head and neck region, and simultaneously analyze the efficacy of different treatment regimens. MethodsA retrospective analysis was performed on all patients with primary untreated head and neck liposarcoma who were dia...
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Magazine House of Cancer Research on Prevention and Treatment
2025-01-01
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| Series: | Zhongliu Fangzhi Yanjiu |
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| Online Access: | http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.0884 |
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| author | Shuo DING Zhigang HUANG Jugao FANG Yang ZHANG Lizhen HOU Wei GUO Gaofei YIN Qi ZHONG |
| author_facet | Shuo DING Zhigang HUANG Jugao FANG Yang ZHANG Lizhen HOU Wei GUO Gaofei YIN Qi ZHONG |
| author_sort | Shuo DING |
| collection | DOAJ |
| description | ObjectiveTo explore the pathogenesis and prognostic factors of liposarcoma in the head and neck region, and simultaneously analyze the efficacy of different treatment regimens. MethodsA retrospective analysis was performed on all patients with primary untreated head and neck liposarcoma who were diagnosed and underwent surgical treatment at our hospital from January 2008 to January 2024. All patients were monitored during follow-up, and their prognoses were analyzed using SPSS software. ResultsA total of 30 patients were included in the study. Liposarcoma accounted for up to 60% of the cases in the orbit, while the remaining liposarcomas were primarily located in various interspaces of the neck. Dedifferentiated liposarcoma was the most common type, comprising 33%, while myxoid pleomorphic liposarcoma was the rarest at 4%. The tumor pathological type (P<0.001) and Ki67 (P=0.014) significantly affected the tumor control rate. However, an analysis of disease-specific survival rates revealed no significant differences across various factors (all P>0.05). ConclusionThe prognosis of head and neck liposarcoma is better compared to that of liposarcomas in other parts of the body. However, myxoid pleomorphic liposarcoma, pleomorphic fat sarcoma, and high Ki67 levels are indicators of poor prognosis. Additionally, postoperative adjuvant radiotherapy does not significantly enhance disease-specific survival rates. |
| format | Article |
| id | doaj-art-a3f6f6bc75d4498ca415a8fce0ef0f7d |
| institution | Kabale University |
| issn | 1000-8578 |
| language | zho |
| publishDate | 2025-01-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj-art-a3f6f6bc75d4498ca415a8fce0ef0f7d2025-01-23T07:44:48ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85782025-01-01521313510.3971/j.issn.1000-8578.2025.24.088420240884Prognostic Factors of Liposarcoma in Head and NeckShuo DING0Zhigang HUANG1Jugao FANG2Yang ZHANG3Lizhen HOU4Wei GUO5Gaofei YIN6Qi ZHONG7Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaDepartment of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaDepartment of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaDepartment of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaDepartment of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaDepartment of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaDepartment of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaDepartment of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaObjectiveTo explore the pathogenesis and prognostic factors of liposarcoma in the head and neck region, and simultaneously analyze the efficacy of different treatment regimens. MethodsA retrospective analysis was performed on all patients with primary untreated head and neck liposarcoma who were diagnosed and underwent surgical treatment at our hospital from January 2008 to January 2024. All patients were monitored during follow-up, and their prognoses were analyzed using SPSS software. ResultsA total of 30 patients were included in the study. Liposarcoma accounted for up to 60% of the cases in the orbit, while the remaining liposarcomas were primarily located in various interspaces of the neck. Dedifferentiated liposarcoma was the most common type, comprising 33%, while myxoid pleomorphic liposarcoma was the rarest at 4%. The tumor pathological type (P<0.001) and Ki67 (P=0.014) significantly affected the tumor control rate. However, an analysis of disease-specific survival rates revealed no significant differences across various factors (all P>0.05). ConclusionThe prognosis of head and neck liposarcoma is better compared to that of liposarcomas in other parts of the body. However, myxoid pleomorphic liposarcoma, pleomorphic fat sarcoma, and high Ki67 levels are indicators of poor prognosis. Additionally, postoperative adjuvant radiotherapy does not significantly enhance disease-specific survival rates.http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.0884head and neckliposarcomaprognosis analysistreatment |
| spellingShingle | Shuo DING Zhigang HUANG Jugao FANG Yang ZHANG Lizhen HOU Wei GUO Gaofei YIN Qi ZHONG Prognostic Factors of Liposarcoma in Head and Neck Zhongliu Fangzhi Yanjiu head and neck liposarcoma prognosis analysis treatment |
| title | Prognostic Factors of Liposarcoma in Head and Neck |
| title_full | Prognostic Factors of Liposarcoma in Head and Neck |
| title_fullStr | Prognostic Factors of Liposarcoma in Head and Neck |
| title_full_unstemmed | Prognostic Factors of Liposarcoma in Head and Neck |
| title_short | Prognostic Factors of Liposarcoma in Head and Neck |
| title_sort | prognostic factors of liposarcoma in head and neck |
| topic | head and neck liposarcoma prognosis analysis treatment |
| url | http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.0884 |
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