Recent Developed Strategies for Enhancing Chondrogenic Differentiation of MSC: Impact on MSC-Based Therapy for Cartilage Regeneration
Articular cartilage is susceptible to damage, but its self-repair is hindered by its avascular nature. Traditional treatment methods are not able to achieve satisfactory repair effects, and the development of tissue engineering techniques has shed new light on cartilage regeneration. Mesenchymal ste...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2021/8830834 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832565875262095360 |
|---|---|
| author | Kangkang Zha Zhiqiang Sun Yu Yang Mingxue Chen Cangjiang Gao Liwei Fu Hao Li Xiang Sui Quanyi Guo Shuyun Liu |
| author_facet | Kangkang Zha Zhiqiang Sun Yu Yang Mingxue Chen Cangjiang Gao Liwei Fu Hao Li Xiang Sui Quanyi Guo Shuyun Liu |
| author_sort | Kangkang Zha |
| collection | DOAJ |
| description | Articular cartilage is susceptible to damage, but its self-repair is hindered by its avascular nature. Traditional treatment methods are not able to achieve satisfactory repair effects, and the development of tissue engineering techniques has shed new light on cartilage regeneration. Mesenchymal stem cells (MSCs) are one of the most commonly used seed cells in cartilage tissue engineering. However, MSCs tend to lose their multipotency, and the composition and structure of cartilage-like tissues formed by MSCs are far from those of native cartilage. Thus, there is an urgent need to develop strategies that promote MSC chondrogenic differentiation to give rise to durable and phenotypically correct regenerated cartilage. This review provides an overview of recent advances in enhancement strategies for MSC chondrogenic differentiation, including optimization of bioactive factors, culture conditions, cell type selection, coculture, gene editing, scaffolds, and physical stimulation. This review will aid the further understanding of the MSC chondrogenic differentiation process and enable improvement of MSC-based cartilage tissue engineering. |
| format | Article |
| id | doaj-art-a3ee7986a95a486b93503f5dedc6746a |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-a3ee7986a95a486b93503f5dedc6746a2025-02-03T01:06:16ZengWileyStem Cells International1687-966X1687-96782021-01-01202110.1155/2021/88308348830834Recent Developed Strategies for Enhancing Chondrogenic Differentiation of MSC: Impact on MSC-Based Therapy for Cartilage RegenerationKangkang Zha0Zhiqiang Sun1Yu Yang2Mingxue Chen3Cangjiang Gao4Liwei Fu5Hao Li6Xiang Sui7Quanyi Guo8Shuyun Liu9Medical School of Chinese PLA, Beijing, ChinaMedical School of Chinese PLA, Beijing, ChinaThe Second People’s Hospital of Guiyang, Guiyang, Guizhou, ChinaDepartment of Orthopaedic Surgery, Beijing Jishuitan Hospital, Fourth Clinical College of Peking University, Beijing, ChinaMedical School of Chinese PLA, Beijing, ChinaMedical School of Chinese PLA, Beijing, ChinaMedical School of Chinese PLA, Beijing, ChinaInstitute of Orthopaedics, Chinese PLA General Hospital; Beijing Key Lab of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, PLA, 28 Fuxing Road, Haidian District, Beijing, ChinaInstitute of Orthopaedics, Chinese PLA General Hospital; Beijing Key Lab of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, PLA, 28 Fuxing Road, Haidian District, Beijing, ChinaInstitute of Orthopaedics, Chinese PLA General Hospital; Beijing Key Lab of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma & War Injuries, PLA, 28 Fuxing Road, Haidian District, Beijing, ChinaArticular cartilage is susceptible to damage, but its self-repair is hindered by its avascular nature. Traditional treatment methods are not able to achieve satisfactory repair effects, and the development of tissue engineering techniques has shed new light on cartilage regeneration. Mesenchymal stem cells (MSCs) are one of the most commonly used seed cells in cartilage tissue engineering. However, MSCs tend to lose their multipotency, and the composition and structure of cartilage-like tissues formed by MSCs are far from those of native cartilage. Thus, there is an urgent need to develop strategies that promote MSC chondrogenic differentiation to give rise to durable and phenotypically correct regenerated cartilage. This review provides an overview of recent advances in enhancement strategies for MSC chondrogenic differentiation, including optimization of bioactive factors, culture conditions, cell type selection, coculture, gene editing, scaffolds, and physical stimulation. This review will aid the further understanding of the MSC chondrogenic differentiation process and enable improvement of MSC-based cartilage tissue engineering.http://dx.doi.org/10.1155/2021/8830834 |
| spellingShingle | Kangkang Zha Zhiqiang Sun Yu Yang Mingxue Chen Cangjiang Gao Liwei Fu Hao Li Xiang Sui Quanyi Guo Shuyun Liu Recent Developed Strategies for Enhancing Chondrogenic Differentiation of MSC: Impact on MSC-Based Therapy for Cartilage Regeneration Stem Cells International |
| title | Recent Developed Strategies for Enhancing Chondrogenic Differentiation of MSC: Impact on MSC-Based Therapy for Cartilage Regeneration |
| title_full | Recent Developed Strategies for Enhancing Chondrogenic Differentiation of MSC: Impact on MSC-Based Therapy for Cartilage Regeneration |
| title_fullStr | Recent Developed Strategies for Enhancing Chondrogenic Differentiation of MSC: Impact on MSC-Based Therapy for Cartilage Regeneration |
| title_full_unstemmed | Recent Developed Strategies for Enhancing Chondrogenic Differentiation of MSC: Impact on MSC-Based Therapy for Cartilage Regeneration |
| title_short | Recent Developed Strategies for Enhancing Chondrogenic Differentiation of MSC: Impact on MSC-Based Therapy for Cartilage Regeneration |
| title_sort | recent developed strategies for enhancing chondrogenic differentiation of msc impact on msc based therapy for cartilage regeneration |
| url | http://dx.doi.org/10.1155/2021/8830834 |
| work_keys_str_mv | AT kangkangzha recentdevelopedstrategiesforenhancingchondrogenicdifferentiationofmscimpactonmscbasedtherapyforcartilageregeneration AT zhiqiangsun recentdevelopedstrategiesforenhancingchondrogenicdifferentiationofmscimpactonmscbasedtherapyforcartilageregeneration AT yuyang recentdevelopedstrategiesforenhancingchondrogenicdifferentiationofmscimpactonmscbasedtherapyforcartilageregeneration AT mingxuechen recentdevelopedstrategiesforenhancingchondrogenicdifferentiationofmscimpactonmscbasedtherapyforcartilageregeneration AT cangjianggao recentdevelopedstrategiesforenhancingchondrogenicdifferentiationofmscimpactonmscbasedtherapyforcartilageregeneration AT liweifu recentdevelopedstrategiesforenhancingchondrogenicdifferentiationofmscimpactonmscbasedtherapyforcartilageregeneration AT haoli recentdevelopedstrategiesforenhancingchondrogenicdifferentiationofmscimpactonmscbasedtherapyforcartilageregeneration AT xiangsui recentdevelopedstrategiesforenhancingchondrogenicdifferentiationofmscimpactonmscbasedtherapyforcartilageregeneration AT quanyiguo recentdevelopedstrategiesforenhancingchondrogenicdifferentiationofmscimpactonmscbasedtherapyforcartilageregeneration AT shuyunliu recentdevelopedstrategiesforenhancingchondrogenicdifferentiationofmscimpactonmscbasedtherapyforcartilageregeneration |