Auditory Stimulation Dishabituates Olfactory Responses via Noradrenergic Cortical Modulation
Dishabituation is a return of a habituated response if context or contingency changes. In the mammalian olfactory system, metabotropic glutamate receptor mediated synaptic depression of cortical afferents underlies short-term habituation to odors. It was hypothesized that a known antagonistic intera...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2009/754014 |
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| author | Jonathan J. Smith Kiseko Shionoya Regina M. Sullivan Donald A. Wilson |
| author_facet | Jonathan J. Smith Kiseko Shionoya Regina M. Sullivan Donald A. Wilson |
| author_sort | Jonathan J. Smith |
| collection | DOAJ |
| description | Dishabituation is a return of a habituated response if context or contingency changes. In the mammalian olfactory system, metabotropic glutamate receptor mediated synaptic depression of cortical afferents underlies short-term habituation to odors. It was hypothesized that a known antagonistic interaction between these receptors and norepinephrine ß-receptors provides a mechanism for dishabituation. The results demonstrate that a
108 dB siren induces a two-fold increase in norepinephrine content in the piriform cortex.
The same auditory stimulus induces dishabituation of odor-evoked heart rate orienting bradycardia
responses in awake rats. Finally, blockade of piriform cortical norepinephrine ß-receptors with bilateral intracortical infusions of propranolol
(100 μM) disrupts auditory-induced dishabituation of odor-evoked bradycardia responses. These results provide a cortical mechanism for a return of habituated sensory responses following a
cross-modal alerting stimulus. |
| format | Article |
| id | doaj-art-a3ec192721a54002a84705d0e6ef4483 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-a3ec192721a54002a84705d0e6ef44832025-02-03T05:46:29ZengWileyNeural Plasticity2090-59041687-54432009-01-01200910.1155/2009/754014754014Auditory Stimulation Dishabituates Olfactory Responses via Noradrenergic Cortical ModulationJonathan J. Smith0Kiseko Shionoya1Regina M. Sullivan2Donald A. Wilson3Department of Zoology, University of Oklahoma, Norman, OK 73019, USADepartment of Zoology, University of Oklahoma, Norman, OK 73019, USADepartment of Zoology, University of Oklahoma, Norman, OK 73019, USADepartment of Zoology, University of Oklahoma, Norman, OK 73019, USADishabituation is a return of a habituated response if context or contingency changes. In the mammalian olfactory system, metabotropic glutamate receptor mediated synaptic depression of cortical afferents underlies short-term habituation to odors. It was hypothesized that a known antagonistic interaction between these receptors and norepinephrine ß-receptors provides a mechanism for dishabituation. The results demonstrate that a 108 dB siren induces a two-fold increase in norepinephrine content in the piriform cortex. The same auditory stimulus induces dishabituation of odor-evoked heart rate orienting bradycardia responses in awake rats. Finally, blockade of piriform cortical norepinephrine ß-receptors with bilateral intracortical infusions of propranolol (100 μM) disrupts auditory-induced dishabituation of odor-evoked bradycardia responses. These results provide a cortical mechanism for a return of habituated sensory responses following a cross-modal alerting stimulus.http://dx.doi.org/10.1155/2009/754014 |
| spellingShingle | Jonathan J. Smith Kiseko Shionoya Regina M. Sullivan Donald A. Wilson Auditory Stimulation Dishabituates Olfactory Responses via Noradrenergic Cortical Modulation Neural Plasticity |
| title | Auditory Stimulation Dishabituates Olfactory Responses via Noradrenergic Cortical Modulation |
| title_full | Auditory Stimulation Dishabituates Olfactory Responses via Noradrenergic Cortical Modulation |
| title_fullStr | Auditory Stimulation Dishabituates Olfactory Responses via Noradrenergic Cortical Modulation |
| title_full_unstemmed | Auditory Stimulation Dishabituates Olfactory Responses via Noradrenergic Cortical Modulation |
| title_short | Auditory Stimulation Dishabituates Olfactory Responses via Noradrenergic Cortical Modulation |
| title_sort | auditory stimulation dishabituates olfactory responses via noradrenergic cortical modulation |
| url | http://dx.doi.org/10.1155/2009/754014 |
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