Auditory Stimulation Dishabituates Olfactory Responses via Noradrenergic Cortical Modulation
Dishabituation is a return of a habituated response if context or contingency changes. In the mammalian olfactory system, metabotropic glutamate receptor mediated synaptic depression of cortical afferents underlies short-term habituation to odors. It was hypothesized that a known antagonistic intera...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2009-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2009/754014 |
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| Summary: | Dishabituation is a return of a habituated response if context or contingency changes. In the mammalian olfactory system, metabotropic glutamate receptor mediated synaptic depression of cortical afferents underlies short-term habituation to odors. It was hypothesized that a known antagonistic interaction between these receptors and norepinephrine ß-receptors provides a mechanism for dishabituation. The results demonstrate that a
108 dB siren induces a two-fold increase in norepinephrine content in the piriform cortex.
The same auditory stimulus induces dishabituation of odor-evoked heart rate orienting bradycardia
responses in awake rats. Finally, blockade of piriform cortical norepinephrine ß-receptors with bilateral intracortical infusions of propranolol
(100 μM) disrupts auditory-induced dishabituation of odor-evoked bradycardia responses. These results provide a cortical mechanism for a return of habituated sensory responses following a
cross-modal alerting stimulus. |
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| ISSN: | 2090-5904 1687-5443 |