Engineering a cell-based orthogonal ubiquitin transfer cascade for profiling the substrates of RBR E3 Parkin

Engineering a cell-based orthogonal ubiquitin transfer cascade for profiling the substrates of RBR E3 Parkin

Summary: The E3 ubiquitin (UB) ligase Parkin utilizes a Ring-Between-Ring (RBR) domain to mediate UB transfer to substrate proteins, and mutations affecting Parkin catalysis promote cancer and are associated with Parkinson’s disease. An essential role of Parkin is to initiate mitophagy by ubiquitina...

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Bibliographic Details
Main Authors: Shuai Fang, Li Zhou, Geng Chen, Jing Zhang, Xiaoyu Wang, In Ho Jeong, Savannah E. Jacobs, Bradley R. Kossmann, Wei Wei, Shu Liu, Geon H. Jeong, Yayun Xie, Duc Duong, Nicholas T. Seyfried, Ivaylo Ivanov, Angela M. Mabb, Hiroaki Kiyokawa, Bo Zhao, Jun Yin
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:iScience
Subjects:
Biochemistry
Protein
Biomolecular engineering
Structural biology
Methodology in biological sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225011745
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