Effect of vitamin D status on a disintegrin-like and metalloprotease with thrombospondin type 1 motif 13 (ADAMTS13) and interleukin 6 in patients with acute myeloid leukaemia

Effect of vitamin D status on a disintegrin-like and metalloprotease with thrombospondin type 1 motif 13 (ADAMTS13) and interleukin 6 in patients with acute myeloid leukaemia

Abstract Background Low levels of the enzyme ADAMTS13 and elevated inflammatory markers such as interleukin-6 (IL-6) are associated with worse outcomes in patients with acute myeloid leukaemia (AML). IL-6 produced by leukaemia cells suppresses ADAMTS13 activity and impairs hematopoietic differentiat...

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Bibliographic Details
Main Authors: Dina Ashraf Abdelhady, Mervat Mostafa Mohamed Azab, Ahmed A. Alnagar, Nora Said
Format: Article
Language:English
Published: BMC 2025-07-01
Series:European Journal of Medical Research
Subjects:
AML
Inflammation
ADAMTS13
IL-6
Vitamin D
Chemotherapy
Online Access:https://doi.org/10.1186/s40001-025-02879-8
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