Umbrella review of adjuvant photodynamic therapy for cholangiocarcinoma palliative treatment
Background: Cholangiocarcinoma is a rare and often fatal malignancy. Numerous studies have demonstrated promising outcomes and survival rates associated with adjuvant photodynamic therapy (PDT) in the palliative treatment of cholangiocarcinoma. Objective: To systematically evaluate the existing meta...
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| Format: | Article |
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Elsevier
2025-02-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S157210002500002X |
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| author | Hanhan Chen Honglin Li Huijie Li Zhen Zhang |
| author_facet | Hanhan Chen Honglin Li Huijie Li Zhen Zhang |
| author_sort | Hanhan Chen |
| collection | DOAJ |
| description | Background: Cholangiocarcinoma is a rare and often fatal malignancy. Numerous studies have demonstrated promising outcomes and survival rates associated with adjuvant photodynamic therapy (PDT) in the palliative treatment of cholangiocarcinoma. Objective: To systematically evaluate the existing meta-analyses on PDT for cholangiocarcinoma, assessing evidence quality and strength while performing updated meta-analyses to refine survival outcomes. Methods: PubMed, EMBASE, Cochrane Library, and Web of Science were systematically searched up to September 18, 2024, to identify meta-analyses and clinical studies on PDT in patients with cholangiocarcinoma. The random-effects model was employed to re-synthesize existing meta-analyses, with a comprehensive evaluation of methodological quality. Updated meta-analyses of survival data were conducted, including subgroup analyses stratified by cholangiocarcinoma type and intervention modality. Results: A total of 5 meta-analyses and 21 clinical studies were included. The findings indicated that combining PDT with stenting or chemotherapy can significantly improve overall survival in patients with cholangiocarcinoma and reduce mortality rate, without increasing the risk of adverse events (AEs) such as cholangitis or abscess formation. For extrahepatic cholangiocarcinoma, adding PDT to stenting demonstrated a notable improvement in the 2-year survival rate. Meanwhile, for hilar cholangiocarcinoma, the addition of chemotherapy to PDT showed a more pronounced enhancement in the 1-year survival rate. Conclusion: Current evidence indicates that PDT combined with stenting or chemotherapy in the palliative treatment of cholangiocarcinoma decreases overall mortality and enhances OS without increasing the incidence of AEs. Adding PDT to stenting or chemotherapy may be more beneficial for long-term efficacy. |
| format | Article |
| id | doaj-art-a3e4132cf5f74b9fae10d06019cbcf4a |
| institution | Kabale University |
| issn | 1572-1000 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
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| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-a3e4132cf5f74b9fae10d06019cbcf4a2025-02-01T04:11:49ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002025-02-0151104472Umbrella review of adjuvant photodynamic therapy for cholangiocarcinoma palliative treatmentHanhan Chen0Honglin Li1Huijie Li2Zhen Zhang3Department of Breast and Thyroid Surgery, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaTraditional Chinese Medicine, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, ChinaDepartment of Oncology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaDepartment of Radiation Oncology, The Third Affiliated Hospital of Shandong First Medical University (Affiliated Hospital of Shandong Academy of Medical Sciences), Jinan, Shandong, China; Corresponding author.Background: Cholangiocarcinoma is a rare and often fatal malignancy. Numerous studies have demonstrated promising outcomes and survival rates associated with adjuvant photodynamic therapy (PDT) in the palliative treatment of cholangiocarcinoma. Objective: To systematically evaluate the existing meta-analyses on PDT for cholangiocarcinoma, assessing evidence quality and strength while performing updated meta-analyses to refine survival outcomes. Methods: PubMed, EMBASE, Cochrane Library, and Web of Science were systematically searched up to September 18, 2024, to identify meta-analyses and clinical studies on PDT in patients with cholangiocarcinoma. The random-effects model was employed to re-synthesize existing meta-analyses, with a comprehensive evaluation of methodological quality. Updated meta-analyses of survival data were conducted, including subgroup analyses stratified by cholangiocarcinoma type and intervention modality. Results: A total of 5 meta-analyses and 21 clinical studies were included. The findings indicated that combining PDT with stenting or chemotherapy can significantly improve overall survival in patients with cholangiocarcinoma and reduce mortality rate, without increasing the risk of adverse events (AEs) such as cholangitis or abscess formation. For extrahepatic cholangiocarcinoma, adding PDT to stenting demonstrated a notable improvement in the 2-year survival rate. Meanwhile, for hilar cholangiocarcinoma, the addition of chemotherapy to PDT showed a more pronounced enhancement in the 1-year survival rate. Conclusion: Current evidence indicates that PDT combined with stenting or chemotherapy in the palliative treatment of cholangiocarcinoma decreases overall mortality and enhances OS without increasing the incidence of AEs. Adding PDT to stenting or chemotherapy may be more beneficial for long-term efficacy.http://www.sciencedirect.com/science/article/pii/S157210002500002XUmbrella reviewMeta-analysisPhotodynamic therapyCholangiocarcinomaSurvivalAdverse effects |
| spellingShingle | Hanhan Chen Honglin Li Huijie Li Zhen Zhang Umbrella review of adjuvant photodynamic therapy for cholangiocarcinoma palliative treatment Photodiagnosis and Photodynamic Therapy Umbrella review Meta-analysis Photodynamic therapy Cholangiocarcinoma Survival Adverse effects |
| title | Umbrella review of adjuvant photodynamic therapy for cholangiocarcinoma palliative treatment |
| title_full | Umbrella review of adjuvant photodynamic therapy for cholangiocarcinoma palliative treatment |
| title_fullStr | Umbrella review of adjuvant photodynamic therapy for cholangiocarcinoma palliative treatment |
| title_full_unstemmed | Umbrella review of adjuvant photodynamic therapy for cholangiocarcinoma palliative treatment |
| title_short | Umbrella review of adjuvant photodynamic therapy for cholangiocarcinoma palliative treatment |
| title_sort | umbrella review of adjuvant photodynamic therapy for cholangiocarcinoma palliative treatment |
| topic | Umbrella review Meta-analysis Photodynamic therapy Cholangiocarcinoma Survival Adverse effects |
| url | http://www.sciencedirect.com/science/article/pii/S157210002500002X |
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