Peanut thresholds in peanut‐allergic children are related to dietary composition
Abstract Background There is no clear explanation for the large variation in threshold levels among peanut‐allergic children. We hypothesized that diet composition can partly explain this variation in thresholds, as nutrients and foods influence the intestinal barrier function and microbiota. Aim to...
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Wiley
2023-05-01
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| Series: | Immunity, Inflammation and Disease |
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| Online Access: | https://doi.org/10.1002/iid3.841 |
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| author | Daisy Luiten Maarten Biezeveld Olga vanDoorn Hanae Riady Ming Yang Femke Bergsma Atie van derPlas Kim Brand Nicolette Arends Annette deBruin Jeanne deVries Tim deMeij Berber Vlieg‐Boerstra |
| author_facet | Daisy Luiten Maarten Biezeveld Olga vanDoorn Hanae Riady Ming Yang Femke Bergsma Atie van derPlas Kim Brand Nicolette Arends Annette deBruin Jeanne deVries Tim deMeij Berber Vlieg‐Boerstra |
| author_sort | Daisy Luiten |
| collection | DOAJ |
| description | Abstract Background There is no clear explanation for the large variation in threshold levels among peanut‐allergic children. We hypothesized that diet composition can partly explain this variation in thresholds, as nutrients and foods influence the intestinal barrier function and microbiota. Aim to explore the relationship between the threshold levels for peanut and nutritional intake and gut microbial composition in peanut‐allergic children. Methods In this explorative cross‐sectional study the cumulative threshold levels for peanut were determined by oral food challenge tests. Data on nutrients and foods consumed were obtained from 3‐day food diaries. Microbial composition of faeces and saliva were determined by molecular microbiota detection technique. Multivariable linear regression analysis and multiple logistic regression were used to explore the associations, adjusted for energy and senitization. Results Sixty‐five children were included, of whom 32 (49%) (median age 50 months, IQR 28.0–96.5) had a positive oral food challenge. Significant positive associations were found between the intake of total carbohydrates, vitamin A and cumulative threshold levels for peanut, while significant negative associations were found for long‐chain polyunsaturated fatty acids, linoleic acid and omega‐6 fatty acids. No associations were found between threshold levels and microbial composition of faeces and saliva. However, a significant higher abundance of Proteobacteria and Bacteroidetes in saliva (p = 0.011 and 0.04, respectively) and of Proteobacteria in faeces (p = 0.003) were found in children with a positive peanut challenge compared to children with a negative peanut challenge. Conclusion As a novel concept, this study showed that dietary composition is related to threshold levels for peanut. |
| format | Article |
| id | doaj-art-a3e196fd7d5241f2844b2c19087acd04 |
| institution | OA Journals |
| issn | 2050-4527 |
| language | English |
| publishDate | 2023-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj-art-a3e196fd7d5241f2844b2c19087acd042025-08-20T02:15:41ZengWileyImmunity, Inflammation and Disease2050-45272023-05-01115n/an/a10.1002/iid3.841Peanut thresholds in peanut‐allergic children are related to dietary compositionDaisy Luiten0Maarten Biezeveld1Olga vanDoorn2Hanae Riady3Ming Yang4Femke Bergsma5Atie van derPlas6Kim Brand7Nicolette Arends8Annette deBruin9Jeanne deVries10Tim deMeij11Berber Vlieg‐Boerstra12Department of Paediatrics OLVG Hospital Amsterdam The NetherlandsDepartment of Paediatrics OLVG Hospital Amsterdam The NetherlandsDepartment of Paediatrics OLVG Hospital Amsterdam The NetherlandsDepartment of Paediatrics OLVG Hospital Amsterdam The NetherlandsDepartment of Paediatrics OLVG Hospital Amsterdam The NetherlandsDepartment of Paediatrics OLVG Hospital Amsterdam The NetherlandsDepartment of Pediatric Pulmonology and Allergology Amsterdam University Medical Centers Amsterdam The NetherlandsDepartment of Pediatric Pulmonology and Allergology Amsterdam University Medical Centers Amsterdam The NetherlandsDepartment of Pediatric Pulmonology and Allergology Erasmus MC Sophia Children's Hospital Rotterdam The NetherlandsDepartment of Paediatrics Tergooi Hospital Blaricum The NetherlandsDivision of Human Nutrition and Health Wageningen University Wageningen The NetherlandsDepartment of Paediatric Gastroenterology Amsterdam University Medical Centers Amsterdam The NetherlandsDepartment of Paediatrics OLVG Hospital Amsterdam The NetherlandsAbstract Background There is no clear explanation for the large variation in threshold levels among peanut‐allergic children. We hypothesized that diet composition can partly explain this variation in thresholds, as nutrients and foods influence the intestinal barrier function and microbiota. Aim to explore the relationship between the threshold levels for peanut and nutritional intake and gut microbial composition in peanut‐allergic children. Methods In this explorative cross‐sectional study the cumulative threshold levels for peanut were determined by oral food challenge tests. Data on nutrients and foods consumed were obtained from 3‐day food diaries. Microbial composition of faeces and saliva were determined by molecular microbiota detection technique. Multivariable linear regression analysis and multiple logistic regression were used to explore the associations, adjusted for energy and senitization. Results Sixty‐five children were included, of whom 32 (49%) (median age 50 months, IQR 28.0–96.5) had a positive oral food challenge. Significant positive associations were found between the intake of total carbohydrates, vitamin A and cumulative threshold levels for peanut, while significant negative associations were found for long‐chain polyunsaturated fatty acids, linoleic acid and omega‐6 fatty acids. No associations were found between threshold levels and microbial composition of faeces and saliva. However, a significant higher abundance of Proteobacteria and Bacteroidetes in saliva (p = 0.011 and 0.04, respectively) and of Proteobacteria in faeces (p = 0.003) were found in children with a positive peanut challenge compared to children with a negative peanut challenge. Conclusion As a novel concept, this study showed that dietary composition is related to threshold levels for peanut.https://doi.org/10.1002/iid3.841dietmicrobiomeoral food challengepeanut allergythresholds |
| spellingShingle | Daisy Luiten Maarten Biezeveld Olga vanDoorn Hanae Riady Ming Yang Femke Bergsma Atie van derPlas Kim Brand Nicolette Arends Annette deBruin Jeanne deVries Tim deMeij Berber Vlieg‐Boerstra Peanut thresholds in peanut‐allergic children are related to dietary composition Immunity, Inflammation and Disease diet microbiome oral food challenge peanut allergy thresholds |
| title | Peanut thresholds in peanut‐allergic children are related to dietary composition |
| title_full | Peanut thresholds in peanut‐allergic children are related to dietary composition |
| title_fullStr | Peanut thresholds in peanut‐allergic children are related to dietary composition |
| title_full_unstemmed | Peanut thresholds in peanut‐allergic children are related to dietary composition |
| title_short | Peanut thresholds in peanut‐allergic children are related to dietary composition |
| title_sort | peanut thresholds in peanut allergic children are related to dietary composition |
| topic | diet microbiome oral food challenge peanut allergy thresholds |
| url | https://doi.org/10.1002/iid3.841 |
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