Sparstolonin B nano-formulation attenuates LPS-induced lung injury

Sparstolonin B nano-formulation attenuates LPS-induced lung injury

IntroductionNanomedicines can improve drug delivery and efficacy while reducing side effects. Our study examines the impact of a nano-formulation of Sparstolonin B (nSsnB), a TLR-4 antagonist, on LPS-induced inflammation in RAW264.7 cells and lung injury in mice.MethodsRAW264.7 cells were treated wi...

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Bibliographic Details
Main Authors: Qinghe Meng, Xiaojing Wang, Dandan Guo, Gary Zhang, Changying Shi, Adam Novak, Xiguang Yang, Juntao Luo, Robert N. Cooney
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
sparstolonin B (nSsnB)
LPS
ALI/ARDS
TLR-4
NF-κB
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1532391/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1532391/full

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