One-Pot Synthesis of Some New Pyrido[2,3-d]pyrimidine Derivatives Catalyzed by Sodium Lauryl Sulfate in Aqueous Media

A series of pyrido[2,3-d]pyrimidine derivatives were synthesized by the three-component reaction of aromatic aldehyde, malononitrile and 6-amino-4-hydroxy-2-mercaptopyrimidine catalyzed by sodium lauryl sulfate (SDS) in aqueous media. It was interesting that further aromatization took place automati...

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Main Authors: Sheng-Hui Li, Yan-Hong Shen, Na Gao, Ji-Tai Li
Format: Article
Language:English
Published: Wiley 2010-01-01
Series:E-Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2010/230707
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author Sheng-Hui Li
Yan-Hong Shen
Na Gao
Ji-Tai Li
author_facet Sheng-Hui Li
Yan-Hong Shen
Na Gao
Ji-Tai Li
author_sort Sheng-Hui Li
collection DOAJ
description A series of pyrido[2,3-d]pyrimidine derivatives were synthesized by the three-component reaction of aromatic aldehyde, malononitrile and 6-amino-4-hydroxy-2-mercaptopyrimidine catalyzed by sodium lauryl sulfate (SDS) in aqueous media. It was interesting that further aromatization took place automatically. This method provides several advantages such as easier work-up, milder reaction conditions and environmental friendly.
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institution OA Journals
issn 0973-4945
2090-9810
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publishDate 2010-01-01
publisher Wiley
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spelling doaj-art-a3d79b51bec44481b13340f81ae7bf942025-08-20T02:20:22ZengWileyE-Journal of Chemistry0973-49452090-98102010-01-017377978410.1155/2010/230707One-Pot Synthesis of Some New Pyrido[2,3-d]pyrimidine Derivatives Catalyzed by Sodium Lauryl Sulfate in Aqueous MediaSheng-Hui Li0Yan-Hong Shen1Na Gao2Ji-Tai Li3Laboratory of Chemical Biology, College of Chemistry and Environmental Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education Hebei University, Baoding, Hebei, 071002, ChinaLaboratory of Chemical Biology, College of Chemistry and Environmental Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education Hebei University, Baoding, Hebei, 071002, ChinaLaboratory of Chemical Biology, College of Chemistry and Environmental Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education Hebei University, Baoding, Hebei, 071002, ChinaLaboratory of Chemical Biology, College of Chemistry and Environmental Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education Hebei University, Baoding, Hebei, 071002, ChinaA series of pyrido[2,3-d]pyrimidine derivatives were synthesized by the three-component reaction of aromatic aldehyde, malononitrile and 6-amino-4-hydroxy-2-mercaptopyrimidine catalyzed by sodium lauryl sulfate (SDS) in aqueous media. It was interesting that further aromatization took place automatically. This method provides several advantages such as easier work-up, milder reaction conditions and environmental friendly.http://dx.doi.org/10.1155/2010/230707
spellingShingle Sheng-Hui Li
Yan-Hong Shen
Na Gao
Ji-Tai Li
One-Pot Synthesis of Some New Pyrido[2,3-d]pyrimidine Derivatives Catalyzed by Sodium Lauryl Sulfate in Aqueous Media
E-Journal of Chemistry
title One-Pot Synthesis of Some New Pyrido[2,3-d]pyrimidine Derivatives Catalyzed by Sodium Lauryl Sulfate in Aqueous Media
title_full One-Pot Synthesis of Some New Pyrido[2,3-d]pyrimidine Derivatives Catalyzed by Sodium Lauryl Sulfate in Aqueous Media
title_fullStr One-Pot Synthesis of Some New Pyrido[2,3-d]pyrimidine Derivatives Catalyzed by Sodium Lauryl Sulfate in Aqueous Media
title_full_unstemmed One-Pot Synthesis of Some New Pyrido[2,3-d]pyrimidine Derivatives Catalyzed by Sodium Lauryl Sulfate in Aqueous Media
title_short One-Pot Synthesis of Some New Pyrido[2,3-d]pyrimidine Derivatives Catalyzed by Sodium Lauryl Sulfate in Aqueous Media
title_sort one pot synthesis of some new pyrido 2 3 d pyrimidine derivatives catalyzed by sodium lauryl sulfate in aqueous media
url http://dx.doi.org/10.1155/2010/230707
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AT nagao onepotsynthesisofsomenewpyrido23dpyrimidinederivativescatalyzedbysodiumlaurylsulfateinaqueousmedia
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