Exploring the repository of de novo-designed bifunctional antimicrobial peptides through deep learning

Exploring the repository of de novo-designed bifunctional antimicrobial peptides through deep learning

Antimicrobial peptides (AMPs) are attractive candidates to combat antibiotic resistance for their capability to target biomembranes and restrict a wide range of pathogens. It is a daunting challenge to discover novel AMPs due to their sparse distributions in a vast peptide universe, especially for p...

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Main Authors: Ruihan Dong, Rongrong Liu, Ziyu Liu, Yangang Liu, Gaomei Zhao, Honglei Li, Shiyuan Hou, Xiaohan Ma, Huarui Kang, Jing Liu, Fei Guo, Ping Zhao, Junping Wang, Cheng Wang, Xingan Wu, Sheng Ye, Cheng Zhu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-03-01
Series:eLife
Subjects:
antimicrobial peptides
antiviral peptides
deep learning
dual-function
generative model
sequence design
Online Access:https://elifesciences.org/articles/97330
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