Molecular Targets for the Treatment of Juvenile Myelomonocytic Leukemia
Significant advances in our understanding of the genetic defects and the pathogenesis of juvenile myelomonocytic leukemia (JMML) have been achieved in the last several years. The information gathered tremendously helps us in designing molecular targeted therapies for this otherwise fatal disease. Va...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2012/308252 |
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| _version_ | 1832547243287117824 |
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| author | Xiaoling Liu Himalee Sabnis Kevin D. Bunting Cheng-Kui Qu |
| author_facet | Xiaoling Liu Himalee Sabnis Kevin D. Bunting Cheng-Kui Qu |
| author_sort | Xiaoling Liu |
| collection | DOAJ |
| description | Significant advances in our understanding of the genetic defects and the pathogenesis of juvenile myelomonocytic leukemia (JMML) have been achieved in the last several years. The information gathered tremendously helps us in designing molecular targeted therapies for this otherwise fatal disease. Various approaches are being investigated to target defective pathways/molecules in this disease. However, effective therapy is still lacking. Development of specific target-based drugs for JMML remains a big challenge and represents a promising direction in this field. |
| format | Article |
| id | doaj-art-a3c807d4cc7147a0ab0d4962d471ff00 |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-a3c807d4cc7147a0ab0d4962d471ff002025-02-03T06:45:29ZengWileyAdvances in Hematology1687-91041687-91122012-01-01201210.1155/2012/308252308252Molecular Targets for the Treatment of Juvenile Myelomonocytic LeukemiaXiaoling Liu0Himalee Sabnis1Kevin D. Bunting2Cheng-Kui Qu3Division of Hematology and Oncology, Department of Medicine, Center for Stem Cell and Regenerative Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USAAflac Cancer Center of Children's Health Care of Atlanta and, Department of Pediatrics, Emory University, Atlanta, GA 30322, USAAflac Cancer Center of Children's Health Care of Atlanta and, Department of Pediatrics, Emory University, Atlanta, GA 30322, USADivision of Hematology and Oncology, Department of Medicine, Center for Stem Cell and Regenerative Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USASignificant advances in our understanding of the genetic defects and the pathogenesis of juvenile myelomonocytic leukemia (JMML) have been achieved in the last several years. The information gathered tremendously helps us in designing molecular targeted therapies for this otherwise fatal disease. Various approaches are being investigated to target defective pathways/molecules in this disease. However, effective therapy is still lacking. Development of specific target-based drugs for JMML remains a big challenge and represents a promising direction in this field.http://dx.doi.org/10.1155/2012/308252 |
| spellingShingle | Xiaoling Liu Himalee Sabnis Kevin D. Bunting Cheng-Kui Qu Molecular Targets for the Treatment of Juvenile Myelomonocytic Leukemia Advances in Hematology |
| title | Molecular Targets for the Treatment of Juvenile Myelomonocytic Leukemia |
| title_full | Molecular Targets for the Treatment of Juvenile Myelomonocytic Leukemia |
| title_fullStr | Molecular Targets for the Treatment of Juvenile Myelomonocytic Leukemia |
| title_full_unstemmed | Molecular Targets for the Treatment of Juvenile Myelomonocytic Leukemia |
| title_short | Molecular Targets for the Treatment of Juvenile Myelomonocytic Leukemia |
| title_sort | molecular targets for the treatment of juvenile myelomonocytic leukemia |
| url | http://dx.doi.org/10.1155/2012/308252 |
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