A low pre-existing anti-NS1 humoral immunity to DENV is associated with microcephaly development after gestational ZIKV exposure.

A low pre-existing anti-NS1 humoral immunity to DENV is associated with microcephaly development after gestational ZIKV exposure.

<h4>Background</h4>Gestational Zika virus (ZIKV) infection is associated with the development of congenital Zika syndrome (CZS), which includes microcephaly and fetal demise. The magnitude and quality of orthoflavivirus-specific humoral immunity have been previously linked to the develop...

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Main Authors: Sebastián Castro-Trujillo, William R Mejía, Katherine Segura, Juanita Castro-Meneses, Rocío Vega, Doris Salgado, Carlos E Fonseca, Ángela M Ortiz, Federico Perdomo-Celis, Irene Bosch, Carlos F Narváez
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0012193
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