Signal integrator function of CXXC5 in Cancer
Abstract CXXC type zinc finger protein 5 (CXXC5) is a member of the ZF-CXXC family and plays a pivotal role in signal integration and information transfer within cell signaling network. CXXC5 acts as a regulator in various physiological processes, and abnormalities in its protein structure or functi...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Cell Communication and Signaling |
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| Online Access: | https://doi.org/10.1186/s12964-024-02005-x |
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| _version_ | 1832594564063428608 |
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| author | Zihao An Jiepu Wang Chengzuo Li Chao Tang |
| author_facet | Zihao An Jiepu Wang Chengzuo Li Chao Tang |
| author_sort | Zihao An |
| collection | DOAJ |
| description | Abstract CXXC type zinc finger protein 5 (CXXC5) is a member of the ZF-CXXC family and plays a pivotal role in signal integration and information transfer within cell signaling network. CXXC5 acts as a regulator in various physiological processes, and abnormalities in its protein structure or function have been linked to multiple pathological processes. In this article, we correspondingly describe the composition of the ZF-CXXC family, emphatically introducing the features of the CXXC5 gene and protein, review the role of CXXC5 in cellular signaling networks, the physiological and pathological processes associated with CXXC5 dysregulation, and particularly focus on the correlation between CXXC5 and cancers. Finally, we summarize the current therapies targeting CXXC5 and their potential applications, and discuss the intriguing findings from current studies, and the opportunities and challenges in future. Graphical Abstract |
| format | Article |
| id | doaj-art-a3a8052db68f4e85b8232ba494000636 |
| institution | Kabale University |
| issn | 1478-811X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj-art-a3a8052db68f4e85b8232ba4940006362025-01-19T12:33:05ZengBMCCell Communication and Signaling1478-811X2025-01-0123111810.1186/s12964-024-02005-xSignal integrator function of CXXC5 in CancerZihao An0Jiepu Wang1Chengzuo Li2Chao Tang3National Clinical Research Center for Child Health of Children’s Hospital, Zhejiang University School of MedicineNational Clinical Research Center for Child Health of Children’s Hospital, Zhejiang University School of MedicineNational Clinical Research Center for Child Health of Children’s Hospital, Zhejiang University School of MedicineNational Clinical Research Center for Child Health of Children’s Hospital, Zhejiang University School of MedicineAbstract CXXC type zinc finger protein 5 (CXXC5) is a member of the ZF-CXXC family and plays a pivotal role in signal integration and information transfer within cell signaling network. CXXC5 acts as a regulator in various physiological processes, and abnormalities in its protein structure or function have been linked to multiple pathological processes. In this article, we correspondingly describe the composition of the ZF-CXXC family, emphatically introducing the features of the CXXC5 gene and protein, review the role of CXXC5 in cellular signaling networks, the physiological and pathological processes associated with CXXC5 dysregulation, and particularly focus on the correlation between CXXC5 and cancers. Finally, we summarize the current therapies targeting CXXC5 and their potential applications, and discuss the intriguing findings from current studies, and the opportunities and challenges in future. Graphical Abstracthttps://doi.org/10.1186/s12964-024-02005-xCXXC5Cell signalingCancerTargeting therapy |
| spellingShingle | Zihao An Jiepu Wang Chengzuo Li Chao Tang Signal integrator function of CXXC5 in Cancer Cell Communication and Signaling CXXC5 Cell signaling Cancer Targeting therapy |
| title | Signal integrator function of CXXC5 in Cancer |
| title_full | Signal integrator function of CXXC5 in Cancer |
| title_fullStr | Signal integrator function of CXXC5 in Cancer |
| title_full_unstemmed | Signal integrator function of CXXC5 in Cancer |
| title_short | Signal integrator function of CXXC5 in Cancer |
| title_sort | signal integrator function of cxxc5 in cancer |
| topic | CXXC5 Cell signaling Cancer Targeting therapy |
| url | https://doi.org/10.1186/s12964-024-02005-x |
| work_keys_str_mv | AT zihaoan signalintegratorfunctionofcxxc5incancer AT jiepuwang signalintegratorfunctionofcxxc5incancer AT chengzuoli signalintegratorfunctionofcxxc5incancer AT chaotang signalintegratorfunctionofcxxc5incancer |