Obesity impact on leukocyte telomere shortening and immune aging assessed by Mendelian randomization and transcriptomics analysis

Obesity impact on leukocyte telomere shortening and immune aging assessed by Mendelian randomization and transcriptomics analysis

Abstract Obesity and aging are key research topics in contemporary biomedical science. While studies have explored the effects of obesity on various health indicators, the precise mechanisms through which obesity may affect leukocyte telomere length (LTL)-and whether this impact contributes to accel...

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Bibliographic Details
Main Authors: Zhijun Feng, Jiacheng Li, Huimin Zhang, Shupeng Liu, Yinghui Wang, Meijuan Zhou, Zhenhua Ding, Lin Xiao
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Immune cell senescence
Leukocyte telomere length
Obesity index
Mendelian randomization
Body mass index
Body fat percentage
Online Access:https://doi.org/10.1038/s41598-025-16817-5
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https://doi.org/10.1038/s41598-025-16817-5

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