Melatonin in Tuberous Sclerosis Complex Analysis Using Modern Mathematical Modeling Methods
Purpose. The aim of the study was to assess melatonin secretion pattern in children with TSC and to compare it with the secretion patterns in children with and without epilepsy. Material and Methods. Melatonin secretion was measured every three hours using the RIA method in four children with recogn...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2017/8234502 |
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| author | Justyna Paprocka Marek Kijonka Łukasz Boguszewicz Maria Sokół |
| author_facet | Justyna Paprocka Marek Kijonka Łukasz Boguszewicz Maria Sokół |
| author_sort | Justyna Paprocka |
| collection | DOAJ |
| description | Purpose. The aim of the study was to assess melatonin secretion pattern in children with TSC and to compare it with the secretion patterns in children with and without epilepsy. Material and Methods. Melatonin secretion was measured every three hours using the RIA method in four children with recognized TSC. The parameters of the melatonin secretion models were interpreted and compared with those obtained for the patients with epilepsy (n=76) and the children from the control, nonepileptic group (n=36). To describe the diurnal melatonin secretion, mathematical model was constructed and nonlinear least squares method with the Levenberg-Marquardt optimization algorithm was applied to approximate its parameters. The dim light melatonin onset (DLMO) parameters were also estimated from the model. Results and Conclusions. Statistically significant differences were found between the TSC melatonin secretion profiles and the nonepileptic control group. The profiles for the epileptic and TSC groups were found to be similar. For the TSC group, though a small one, the variations in the MLT release amplitudes seem to be independent of the total number of seizures; however, the MLT release shift appears to depend on the number of seizures. |
| format | Article |
| id | doaj-art-a397a929ad7e4bf5ab07bdecd436a862 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-a397a929ad7e4bf5ab07bdecd436a8622025-02-03T01:27:18ZengWileyInternational Journal of Endocrinology1687-83371687-83452017-01-01201710.1155/2017/82345028234502Melatonin in Tuberous Sclerosis Complex Analysis Using Modern Mathematical Modeling MethodsJustyna Paprocka0Marek Kijonka1Łukasz Boguszewicz2Maria Sokół3Department of Pediatric Neurology, School of Medicine in Katowice, Medical University of Silesia, Katowice, PolandDepartment of Medical Physics, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandDepartment of Medical Physics, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandDepartment of Medical Physics, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, PolandPurpose. The aim of the study was to assess melatonin secretion pattern in children with TSC and to compare it with the secretion patterns in children with and without epilepsy. Material and Methods. Melatonin secretion was measured every three hours using the RIA method in four children with recognized TSC. The parameters of the melatonin secretion models were interpreted and compared with those obtained for the patients with epilepsy (n=76) and the children from the control, nonepileptic group (n=36). To describe the diurnal melatonin secretion, mathematical model was constructed and nonlinear least squares method with the Levenberg-Marquardt optimization algorithm was applied to approximate its parameters. The dim light melatonin onset (DLMO) parameters were also estimated from the model. Results and Conclusions. Statistically significant differences were found between the TSC melatonin secretion profiles and the nonepileptic control group. The profiles for the epileptic and TSC groups were found to be similar. For the TSC group, though a small one, the variations in the MLT release amplitudes seem to be independent of the total number of seizures; however, the MLT release shift appears to depend on the number of seizures.http://dx.doi.org/10.1155/2017/8234502 |
| spellingShingle | Justyna Paprocka Marek Kijonka Łukasz Boguszewicz Maria Sokół Melatonin in Tuberous Sclerosis Complex Analysis Using Modern Mathematical Modeling Methods International Journal of Endocrinology |
| title | Melatonin in Tuberous Sclerosis Complex Analysis Using Modern Mathematical Modeling Methods |
| title_full | Melatonin in Tuberous Sclerosis Complex Analysis Using Modern Mathematical Modeling Methods |
| title_fullStr | Melatonin in Tuberous Sclerosis Complex Analysis Using Modern Mathematical Modeling Methods |
| title_full_unstemmed | Melatonin in Tuberous Sclerosis Complex Analysis Using Modern Mathematical Modeling Methods |
| title_short | Melatonin in Tuberous Sclerosis Complex Analysis Using Modern Mathematical Modeling Methods |
| title_sort | melatonin in tuberous sclerosis complex analysis using modern mathematical modeling methods |
| url | http://dx.doi.org/10.1155/2017/8234502 |
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