Structural engineering of stabilized, expanded epitope nanoparticle vaccines for HPV

Structural engineering of stabilized, expanded epitope nanoparticle vaccines for HPV

Oncogenic forms of HPV account for 4.5% of the global cancer burden worldwide. This includes cervical, vaginal, vulvar, penile, and anal cancers, as well as head and neck cancers. As such, there is an urgent need to develop effective therapeutic vaccines to drive the immune system’s cellular respons...

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Bibliographic Details
Main Authors: Michaela Helble, Xizhou Zhu, Pratik S. Bhojnagarwala, Kevin Liaw, Yangcheng Gao, Amber Kim, Kelly Bayruns, Madison E. McCanna, Joyce Park, Kylie M. Konrath, Sam Garfinkle, Taylor Brysgel, David B. Weiner, Daniel W. Kulp
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
AI
AlphaFold
MHC-restriction
CTL
HPV
nanoparticle
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1535261/full
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