Exosomes in cartilage microenvironment regulation and cartilage repair
Osteoarthritis (OA) is a debilitating disease that predominantly impacts the hip, hand, and knee joints. Its pathology is defined by the progressive degradation of articular cartilage, formation of bone spurs, and synovial inflammation, resulting in pain, joint function limitations, and substantial...
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1460416/full |
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| author | Han Longfei Hou Wenyuan Fang Weihua Peng Peng Lu Sun Lin Kun He Mincong He Mincong Yang Fan Yang Fan He Wei He Wei Wei Qiushi Wei Qiushi Wei Qiushi |
| author_facet | Han Longfei Hou Wenyuan Fang Weihua Peng Peng Lu Sun Lin Kun He Mincong He Mincong Yang Fan Yang Fan He Wei He Wei Wei Qiushi Wei Qiushi Wei Qiushi |
| author_sort | Han Longfei |
| collection | DOAJ |
| description | Osteoarthritis (OA) is a debilitating disease that predominantly impacts the hip, hand, and knee joints. Its pathology is defined by the progressive degradation of articular cartilage, formation of bone spurs, and synovial inflammation, resulting in pain, joint function limitations, and substantial societal and familial burdens. Current treatment strategies primarily target pain alleviation, yet improved interventions addressing the underlying disease pathology are scarce. Recently, exosomes have emerged as a subject of growing interest in OA therapy. Numerous studies have investigated exosomes to offer promising therapeutic approaches for OA through diverse in vivo and in vitro models, elucidating the mechanisms by which exosomes from various cell sources modulate the cartilage microenvironment and promote cartilage repair. Preclinical investigations have demonstrated the regulatory effects of exosomes originating from human cells, including mesenchymal stem cells (MSC), synovial fibroblasts, chondrocytes, macrophages, and exosomes derived from Chinese herbal medicines, on the modulation of the cartilage microenvironment and cartilage repair through diverse signaling pathways. Additionally, therapeutic mechanisms encompass cartilage inflammation, degradation of the cartilage matrix, proliferation and migration of chondrocytes, autophagy, apoptosis, and mitigation of oxidative stress. An increasing number of exosome carrier scaffolds are under development. Our review adopts a multidimensional approach to enhance comprehension of the pivotal therapeutic functions exerted by exosomes sourced from diverse cell types in OA. Ultimately, our aim is to pinpoint therapeutic targets capable of regulating the cartilage microenvironment and facilitating cartilage repair in OA. |
| format | Article |
| id | doaj-art-a3726ef429e3498babc3a66ed2d85b01 |
| institution | OA Journals |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-a3726ef429e3498babc3a66ed2d85b012025-08-20T02:02:02ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-03-011310.3389/fcell.2025.14604161460416Exosomes in cartilage microenvironment regulation and cartilage repairHan Longfei0Hou Wenyuan1Fang Weihua2Peng Peng3Lu Sun4Lin Kun5He Mincong6He Mincong7Yang Fan8Yang Fan9He Wei10He Wei11Wei Qiushi12Wei Qiushi13Wei Qiushi14Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaGuangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaGuangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaGuangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaGuangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaGuangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaTraumatology and Orthopedics Institute of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaDepartment of Orthopaedics, The Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaTraumatology and Orthopedics Institute of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaDepartment of Orthopaedics, The Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaTraumatology and Orthopedics Institute of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaDepartment of Orthopaedics, The Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaTraumatology and Orthopedics Institute of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaDepartment of Orthopaedics, The Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaState Key Laboratory of Traditional Chinese Medicine Syndrome/Orthopaedic, The Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaOsteoarthritis (OA) is a debilitating disease that predominantly impacts the hip, hand, and knee joints. Its pathology is defined by the progressive degradation of articular cartilage, formation of bone spurs, and synovial inflammation, resulting in pain, joint function limitations, and substantial societal and familial burdens. Current treatment strategies primarily target pain alleviation, yet improved interventions addressing the underlying disease pathology are scarce. Recently, exosomes have emerged as a subject of growing interest in OA therapy. Numerous studies have investigated exosomes to offer promising therapeutic approaches for OA through diverse in vivo and in vitro models, elucidating the mechanisms by which exosomes from various cell sources modulate the cartilage microenvironment and promote cartilage repair. Preclinical investigations have demonstrated the regulatory effects of exosomes originating from human cells, including mesenchymal stem cells (MSC), synovial fibroblasts, chondrocytes, macrophages, and exosomes derived from Chinese herbal medicines, on the modulation of the cartilage microenvironment and cartilage repair through diverse signaling pathways. Additionally, therapeutic mechanisms encompass cartilage inflammation, degradation of the cartilage matrix, proliferation and migration of chondrocytes, autophagy, apoptosis, and mitigation of oxidative stress. An increasing number of exosome carrier scaffolds are under development. Our review adopts a multidimensional approach to enhance comprehension of the pivotal therapeutic functions exerted by exosomes sourced from diverse cell types in OA. Ultimately, our aim is to pinpoint therapeutic targets capable of regulating the cartilage microenvironment and facilitating cartilage repair in OA.https://www.frontiersin.org/articles/10.3389/fcell.2025.1460416/fullexosomesosteoarthritiscartilage repaircartilage microenvironmentmechanism of action |
| spellingShingle | Han Longfei Hou Wenyuan Fang Weihua Peng Peng Lu Sun Lin Kun He Mincong He Mincong Yang Fan Yang Fan He Wei He Wei Wei Qiushi Wei Qiushi Wei Qiushi Exosomes in cartilage microenvironment regulation and cartilage repair Frontiers in Cell and Developmental Biology exosomes osteoarthritis cartilage repair cartilage microenvironment mechanism of action |
| title | Exosomes in cartilage microenvironment regulation and cartilage repair |
| title_full | Exosomes in cartilage microenvironment regulation and cartilage repair |
| title_fullStr | Exosomes in cartilage microenvironment regulation and cartilage repair |
| title_full_unstemmed | Exosomes in cartilage microenvironment regulation and cartilage repair |
| title_short | Exosomes in cartilage microenvironment regulation and cartilage repair |
| title_sort | exosomes in cartilage microenvironment regulation and cartilage repair |
| topic | exosomes osteoarthritis cartilage repair cartilage microenvironment mechanism of action |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1460416/full |
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