Bifidobacterium animalis Probio-M8 improves sarcopenia physical performance by mitigating creatine restrictions imposed by microbial metabolites
Abstract Sarcopenia is a major health challenge due to an aging population. Probiotics may improve muscle function through gut-muscle axis, but their efficacy and mechanisms in treating sarcopenia remain unclear. This study investigated the impact of Bifidobacterium animalis subsp. lactis Probio-M8...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-12-01
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| Series: | npj Biofilms and Microbiomes |
| Online Access: | https://doi.org/10.1038/s41522-024-00618-1 |
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| author | Zeng Zhang Yajing Fang Yangli He Mohamed A. Farag Min Zeng Yukai Sun Siqi Peng Shuaiming Jiang Xian Zhang Kaining Chen Meng Xu Zhe Han Jiachao Zhang |
| author_facet | Zeng Zhang Yajing Fang Yangli He Mohamed A. Farag Min Zeng Yukai Sun Siqi Peng Shuaiming Jiang Xian Zhang Kaining Chen Meng Xu Zhe Han Jiachao Zhang |
| author_sort | Zeng Zhang |
| collection | DOAJ |
| description | Abstract Sarcopenia is a major health challenge due to an aging population. Probiotics may improve muscle function through gut-muscle axis, but their efficacy and mechanisms in treating sarcopenia remain unclear. This study investigated the impact of Bifidobacterium animalis subsp. lactis Probio-M8 (Probio-M8) on old mice and sarcopenia patients. We analyzed 43 subjects, including gut microbiome, fecal metabolome, and serum metabolome, using a multi-omics approach to assess whether Probio-M8 can improve sarcopenia by modulating gut microbial metabolites. Probio-M8 significantly improved muscle function in aged mice and enhanced physical performance in sarcopenia patients. It reduced pathogenic gut species and increased beneficial metabolites such as indole-3-lactic acid, acetoacetic acid, and creatine. Mediating effect analyses revealed that Probio-M8 effectively reduced n-dodecanoyl-L-homoserine lactone level in gut concurrent with increased creatine circulation, to significantly enhance host physical properties. These findings provide new insights into probiotics as a potential treatment for sarcopenia by modulating gut microbiota metabolism. |
| format | Article |
| id | doaj-art-a364aad863a14e00ba89e5f71f69e222 |
| institution | Kabale University |
| issn | 2055-5008 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Biofilms and Microbiomes |
| spelling | doaj-art-a364aad863a14e00ba89e5f71f69e2222025-02-02T12:11:08ZengNature Portfolionpj Biofilms and Microbiomes2055-50082024-12-0110111410.1038/s41522-024-00618-1Bifidobacterium animalis Probio-M8 improves sarcopenia physical performance by mitigating creatine restrictions imposed by microbial metabolitesZeng Zhang0Yajing Fang1Yangli He2Mohamed A. Farag3Min Zeng4Yukai Sun5Siqi Peng6Shuaiming Jiang7Xian Zhang8Kaining Chen9Meng Xu10Zhe Han11Jiachao Zhang12School of Food Science and Engineering, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Hainan UniversitySchool of Food Science and Engineering, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Hainan UniversityDepartment of Health Center, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical UniversityPharmacognosy Department, College of Pharmacy, Cairo UniversityDepartment of Health Center, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical UniversitySchool of Food Science and Engineering, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Hainan UniversitySchool of Food Science and Engineering, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Hainan UniversitySchool of Food Science and Engineering, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Hainan UniversityDepartment of Endocrinology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical UniversityDepartment of Endocrinology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical UniversitySchool of Food Science and Engineering, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Hainan UniversitySchool of Food Science and Engineering, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Hainan UniversitySchool of Food Science and Engineering, Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Hainan UniversityAbstract Sarcopenia is a major health challenge due to an aging population. Probiotics may improve muscle function through gut-muscle axis, but their efficacy and mechanisms in treating sarcopenia remain unclear. This study investigated the impact of Bifidobacterium animalis subsp. lactis Probio-M8 (Probio-M8) on old mice and sarcopenia patients. We analyzed 43 subjects, including gut microbiome, fecal metabolome, and serum metabolome, using a multi-omics approach to assess whether Probio-M8 can improve sarcopenia by modulating gut microbial metabolites. Probio-M8 significantly improved muscle function in aged mice and enhanced physical performance in sarcopenia patients. It reduced pathogenic gut species and increased beneficial metabolites such as indole-3-lactic acid, acetoacetic acid, and creatine. Mediating effect analyses revealed that Probio-M8 effectively reduced n-dodecanoyl-L-homoserine lactone level in gut concurrent with increased creatine circulation, to significantly enhance host physical properties. These findings provide new insights into probiotics as a potential treatment for sarcopenia by modulating gut microbiota metabolism.https://doi.org/10.1038/s41522-024-00618-1 |
| spellingShingle | Zeng Zhang Yajing Fang Yangli He Mohamed A. Farag Min Zeng Yukai Sun Siqi Peng Shuaiming Jiang Xian Zhang Kaining Chen Meng Xu Zhe Han Jiachao Zhang Bifidobacterium animalis Probio-M8 improves sarcopenia physical performance by mitigating creatine restrictions imposed by microbial metabolites npj Biofilms and Microbiomes |
| title | Bifidobacterium animalis Probio-M8 improves sarcopenia physical performance by mitigating creatine restrictions imposed by microbial metabolites |
| title_full | Bifidobacterium animalis Probio-M8 improves sarcopenia physical performance by mitigating creatine restrictions imposed by microbial metabolites |
| title_fullStr | Bifidobacterium animalis Probio-M8 improves sarcopenia physical performance by mitigating creatine restrictions imposed by microbial metabolites |
| title_full_unstemmed | Bifidobacterium animalis Probio-M8 improves sarcopenia physical performance by mitigating creatine restrictions imposed by microbial metabolites |
| title_short | Bifidobacterium animalis Probio-M8 improves sarcopenia physical performance by mitigating creatine restrictions imposed by microbial metabolites |
| title_sort | bifidobacterium animalis probio m8 improves sarcopenia physical performance by mitigating creatine restrictions imposed by microbial metabolites |
| url | https://doi.org/10.1038/s41522-024-00618-1 |
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