Verification of the Functional Antioxidant Activity and Antimelanogenic Properties of Extracts of Poria cocos Mycelium Fermented with Freeze-Dried Plum Powder
Here we examine the effects of extracts of Poria cocos mycelium fermented with freeze-dried plum powder (PPE) on the α-melanocyte stimulating hormone (α-MSH)-stimulated melanogenesis in cultured murine B16 melanoma cells (B16 cells), relative to the effects of Prunus extract. We found that an extrac...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | International Journal of Biomaterials |
| Online Access: | http://dx.doi.org/10.1155/2019/9283207 |
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| author | Kyung-Yun Kang Yun-Ho Hwang Sung-Ju Lee Ho-Yeol Jang Seong-Gyeol Hong Seul-Ki Mun Su-Jin Kim Jong-Jin Kim Kuyng-Wuk Park Kyoung-Sun Seo Seung-Eon Ban Seong-Woo Jin Hyuck-Joo Kim Sung-Tae Yee |
| author_facet | Kyung-Yun Kang Yun-Ho Hwang Sung-Ju Lee Ho-Yeol Jang Seong-Gyeol Hong Seul-Ki Mun Su-Jin Kim Jong-Jin Kim Kuyng-Wuk Park Kyoung-Sun Seo Seung-Eon Ban Seong-Woo Jin Hyuck-Joo Kim Sung-Tae Yee |
| author_sort | Kyung-Yun Kang |
| collection | DOAJ |
| description | Here we examine the effects of extracts of Poria cocos mycelium fermented with freeze-dried plum powder (PPE) on the α-melanocyte stimulating hormone (α-MSH)-stimulated melanogenesis in cultured murine B16 melanoma cells (B16 cells), relative to the effects of Prunus extract. We found that an extract of Prunus fermentation showed significant inhibition of melanogenesis and tyrosinase activity with no effect on cell proliferation and was more active compared to Prunus extract alone. Furthermore, we confirmed that medium containing 3% Prunus was the optimal culture substrate for fermentation with Poria cocos. These results provide evidence that Prunus fermentation extract affects skin whiting in murine B16 melanoma cells (B16 cells). Prunus contains rutin, oxalic acid, succinic acid, and fumaric acid, which help in digestion and fatigue recovery. The rutin of Prunus mume is reported to have antioxidant and anti-inflammatory effects. Also, Prunus extract has a tyrosinase inhibitory activity for skin whiting through its antioxidant activity. Therefore, we believe the Prunus extract for Poria cocos fermentation can be provided as a potential mediator to induce skin whiting. |
| format | Article |
| id | doaj-art-a361a53284144ccebde524d83afd2a7a |
| institution | Kabale University |
| issn | 1687-8787 1687-8795 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomaterials |
| spelling | doaj-art-a361a53284144ccebde524d83afd2a7a2025-02-03T06:13:42ZengWileyInternational Journal of Biomaterials1687-87871687-87952019-01-01201910.1155/2019/92832079283207Verification of the Functional Antioxidant Activity and Antimelanogenic Properties of Extracts of Poria cocos Mycelium Fermented with Freeze-Dried Plum PowderKyung-Yun Kang0Yun-Ho Hwang1Sung-Ju Lee2Ho-Yeol Jang3Seong-Gyeol Hong4Seul-Ki Mun5Su-Jin Kim6Jong-Jin Kim7Kuyng-Wuk Park8Kyoung-Sun Seo9Seung-Eon Ban10Seong-Woo Jin11Hyuck-Joo Kim12Sung-Tae Yee13Suncheon Research Center for Natural Medicines, Suncheon, Republic of KoreaDepartment of Pharmacy, Sunchon National University, Suncheon 540-742, Republic of KoreaSuncheon Research Center for Natural Medicines, Suncheon, Republic of KoreaDepartment of Pharmacy, Sunchon National University, Suncheon 540-742, Republic of KoreaDepartment of Pharmacy, Sunchon National University, Suncheon 540-742, Republic of KoreaDepartment of Pharmacy, Sunchon National University, Suncheon 540-742, Republic of KoreaDepartment of Pharmacy, Sunchon National University, Suncheon 540-742, Republic of KoreaCenter for Self-Assembly and Complexity, Institute for Basic Science (IBS), Pohang 37673, Republic of KoreaSuncheon Research Center for Natural Medicines, Suncheon, Republic of KoreaJangheung Research Institute for Mushroom Industry 288, Woodlannd-gil, Gisan-ri, Anyang-myeon, Jangheung-gun, Jeollanam-do 529-805, Republic of KoreaJangheung Research Institute for Mushroom Industry 288, Woodlannd-gil, Gisan-ri, Anyang-myeon, Jangheung-gun, Jeollanam-do 529-805, Republic of KoreaJangheung Research Institute for Mushroom Industry 288, Woodlannd-gil, Gisan-ri, Anyang-myeon, Jangheung-gun, Jeollanam-do 529-805, Republic of KoreaDepartment of Industrial Machinery Engineering, Sunchon National University, Suncheon 540-742, Republic of KoreaDepartment of Pharmacy, Sunchon National University, Suncheon 540-742, Republic of KoreaHere we examine the effects of extracts of Poria cocos mycelium fermented with freeze-dried plum powder (PPE) on the α-melanocyte stimulating hormone (α-MSH)-stimulated melanogenesis in cultured murine B16 melanoma cells (B16 cells), relative to the effects of Prunus extract. We found that an extract of Prunus fermentation showed significant inhibition of melanogenesis and tyrosinase activity with no effect on cell proliferation and was more active compared to Prunus extract alone. Furthermore, we confirmed that medium containing 3% Prunus was the optimal culture substrate for fermentation with Poria cocos. These results provide evidence that Prunus fermentation extract affects skin whiting in murine B16 melanoma cells (B16 cells). Prunus contains rutin, oxalic acid, succinic acid, and fumaric acid, which help in digestion and fatigue recovery. The rutin of Prunus mume is reported to have antioxidant and anti-inflammatory effects. Also, Prunus extract has a tyrosinase inhibitory activity for skin whiting through its antioxidant activity. Therefore, we believe the Prunus extract for Poria cocos fermentation can be provided as a potential mediator to induce skin whiting.http://dx.doi.org/10.1155/2019/9283207 |
| spellingShingle | Kyung-Yun Kang Yun-Ho Hwang Sung-Ju Lee Ho-Yeol Jang Seong-Gyeol Hong Seul-Ki Mun Su-Jin Kim Jong-Jin Kim Kuyng-Wuk Park Kyoung-Sun Seo Seung-Eon Ban Seong-Woo Jin Hyuck-Joo Kim Sung-Tae Yee Verification of the Functional Antioxidant Activity and Antimelanogenic Properties of Extracts of Poria cocos Mycelium Fermented with Freeze-Dried Plum Powder International Journal of Biomaterials |
| title | Verification of the Functional Antioxidant Activity and Antimelanogenic Properties of Extracts of Poria cocos Mycelium Fermented with Freeze-Dried Plum Powder |
| title_full | Verification of the Functional Antioxidant Activity and Antimelanogenic Properties of Extracts of Poria cocos Mycelium Fermented with Freeze-Dried Plum Powder |
| title_fullStr | Verification of the Functional Antioxidant Activity and Antimelanogenic Properties of Extracts of Poria cocos Mycelium Fermented with Freeze-Dried Plum Powder |
| title_full_unstemmed | Verification of the Functional Antioxidant Activity and Antimelanogenic Properties of Extracts of Poria cocos Mycelium Fermented with Freeze-Dried Plum Powder |
| title_short | Verification of the Functional Antioxidant Activity and Antimelanogenic Properties of Extracts of Poria cocos Mycelium Fermented with Freeze-Dried Plum Powder |
| title_sort | verification of the functional antioxidant activity and antimelanogenic properties of extracts of poria cocos mycelium fermented with freeze dried plum powder |
| url | http://dx.doi.org/10.1155/2019/9283207 |
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