Ectopic Functioning Adrenocortical Oncocytic Adenoma (Oncocytoma) with Myelolipoma Causing Virilization
Functioning adrenal adenomas are well-described entities that can rarely occur outside the adrenal gland in the ectopic adrenal tissue. Similarly, myelolipoma is an another benign lesion of the adrenal tissue which can rarely occur outside the adrenal gland. We report the first case of a testosteron...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2012/326418 |
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| author | Lea F. Surrey Ashesh A. Thaker Paul J. Zhang Giorgos Karakousis Michael D. Feldman |
| author_facet | Lea F. Surrey Ashesh A. Thaker Paul J. Zhang Giorgos Karakousis Michael D. Feldman |
| author_sort | Lea F. Surrey |
| collection | DOAJ |
| description | Functioning adrenal adenomas are well-described entities that can rarely occur outside the adrenal gland in the ectopic adrenal tissue. Similarly, myelolipoma is an another benign lesion of the adrenal tissue which can rarely occur outside the adrenal gland. We report the first case of a testosterone producing an extra-adrenal adrenocortical oncocytoma accompanied by a myelolipoma. The patient presented with virilization and elevated androgen levels. Imaging revealed a retroperitoneal mass, which histologically consisted of oncocytes and intermingled myelolipoma. Postoperative androgen levels decreased to normal. The tumor cells were strongly positive for inhibin and Melan-A, supporting the adrenal origin. This case demonstrates a diagnostic challenge in which correlation with histology, immunohistochemistry, and serum endocrine studies led to the final diagnosis. |
| format | Article |
| id | doaj-art-a351c14446d94fbfabd21abb057b2e5f |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
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| series | Case Reports in Pathology |
| spelling | doaj-art-a351c14446d94fbfabd21abb057b2e5f2025-02-03T01:20:41ZengWileyCase Reports in Pathology2090-67812090-679X2012-01-01201210.1155/2012/326418326418Ectopic Functioning Adrenocortical Oncocytic Adenoma (Oncocytoma) with Myelolipoma Causing VirilizationLea F. Surrey0Ashesh A. Thaker1Paul J. Zhang2Giorgos Karakousis3Michael D. Feldman4Department of Pathology and Laboratory Medicine, The Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USADepartment of Radiology, The Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USADepartment of Pathology and Laboratory Medicine, The Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USADepartment of Surgery, The Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USADepartment of Pathology and Laboratory Medicine, The Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USAFunctioning adrenal adenomas are well-described entities that can rarely occur outside the adrenal gland in the ectopic adrenal tissue. Similarly, myelolipoma is an another benign lesion of the adrenal tissue which can rarely occur outside the adrenal gland. We report the first case of a testosterone producing an extra-adrenal adrenocortical oncocytoma accompanied by a myelolipoma. The patient presented with virilization and elevated androgen levels. Imaging revealed a retroperitoneal mass, which histologically consisted of oncocytes and intermingled myelolipoma. Postoperative androgen levels decreased to normal. The tumor cells were strongly positive for inhibin and Melan-A, supporting the adrenal origin. This case demonstrates a diagnostic challenge in which correlation with histology, immunohistochemistry, and serum endocrine studies led to the final diagnosis.http://dx.doi.org/10.1155/2012/326418 |
| spellingShingle | Lea F. Surrey Ashesh A. Thaker Paul J. Zhang Giorgos Karakousis Michael D. Feldman Ectopic Functioning Adrenocortical Oncocytic Adenoma (Oncocytoma) with Myelolipoma Causing Virilization Case Reports in Pathology |
| title | Ectopic Functioning Adrenocortical Oncocytic Adenoma (Oncocytoma) with Myelolipoma Causing Virilization |
| title_full | Ectopic Functioning Adrenocortical Oncocytic Adenoma (Oncocytoma) with Myelolipoma Causing Virilization |
| title_fullStr | Ectopic Functioning Adrenocortical Oncocytic Adenoma (Oncocytoma) with Myelolipoma Causing Virilization |
| title_full_unstemmed | Ectopic Functioning Adrenocortical Oncocytic Adenoma (Oncocytoma) with Myelolipoma Causing Virilization |
| title_short | Ectopic Functioning Adrenocortical Oncocytic Adenoma (Oncocytoma) with Myelolipoma Causing Virilization |
| title_sort | ectopic functioning adrenocortical oncocytic adenoma oncocytoma with myelolipoma causing virilization |
| url | http://dx.doi.org/10.1155/2012/326418 |
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