MicroRNAs as regulators of drug abuse and immunity
MicroRNAs (miRNAs) are 20-22 nucleotide non-coding RNAs that participate in gene regulation. They bind to 3’-untranslated regions of their mRNA targets, inhibiting the transcripts’ translation and/or destabilizing them. Chronic drug abuse induces changes of miRNAs expression in the brain, which is t...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2017-01-01
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| Series: | Central European Journal of Immunology |
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| Online Access: | https://www.termedia.pl/MicroRNAs-as-regulators-of-drug-abuse-and-immunity,10,29104,1,1.html |
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| _version_ | 1850211987379716096 |
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| author | Kai Zhang Xuxiu Jing Guoqiang Wang |
| author_facet | Kai Zhang Xuxiu Jing Guoqiang Wang |
| author_sort | Kai Zhang |
| collection | DOAJ |
| description | MicroRNAs (miRNAs) are 20-22 nucleotide non-coding RNAs that participate in gene regulation. They bind to 3’-untranslated regions of their mRNA targets, inhibiting the transcripts’ translation and/or destabilizing them. Chronic drug abuse induces changes of miRNAs expression in the brain, which is thought to contribute to addictive behaviors. Lots of miRNAs have been identified to play critical roles in the development of drug addiction. Moreover, miRNAs have been shown to play critical roles in a broad array of biologic processes, including regulation of the cell cycle, oncogenic transformation, immune cell regeneration and differentiation, and psychiatry disorders. We hypothesized that chronic drug abuse leads to aberrant expression of several miRNAs, and then aberrant miRNAs influence the innate and adaptive immunity, especially differentiation and function of T cells and B cells, through down-regulated miRNAs’ target gene expression. Characterization of miRNA actions is important and has high potential effect for the management of drug addiction and immunity diseases. miRNAs are potential biomarkers, and the modulation of their expression can be used for therapeutic purposes. |
| format | Article |
| id | doaj-art-a3473cce8b6941b9b9415e7439f85fea |
| institution | OA Journals |
| issn | 1426-3912 1644-4124 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Central European Journal of Immunology |
| spelling | doaj-art-a3473cce8b6941b9b9415e7439f85fea2025-08-20T02:09:25ZengTermedia Publishing HouseCentral European Journal of Immunology1426-39121644-41242017-01-0141442643410.5114/ceji.2016.6514229104MicroRNAs as regulators of drug abuse and immunityKai ZhangXuxiu JingGuoqiang WangMicroRNAs (miRNAs) are 20-22 nucleotide non-coding RNAs that participate in gene regulation. They bind to 3’-untranslated regions of their mRNA targets, inhibiting the transcripts’ translation and/or destabilizing them. Chronic drug abuse induces changes of miRNAs expression in the brain, which is thought to contribute to addictive behaviors. Lots of miRNAs have been identified to play critical roles in the development of drug addiction. Moreover, miRNAs have been shown to play critical roles in a broad array of biologic processes, including regulation of the cell cycle, oncogenic transformation, immune cell regeneration and differentiation, and psychiatry disorders. We hypothesized that chronic drug abuse leads to aberrant expression of several miRNAs, and then aberrant miRNAs influence the innate and adaptive immunity, especially differentiation and function of T cells and B cells, through down-regulated miRNAs’ target gene expression. Characterization of miRNA actions is important and has high potential effect for the management of drug addiction and immunity diseases. miRNAs are potential biomarkers, and the modulation of their expression can be used for therapeutic purposes.https://www.termedia.pl/MicroRNAs-as-regulators-of-drug-abuse-and-immunity,10,29104,1,1.html<i>innate immunity microRNA immunity drug abuse adaptive immunity</i> |
| spellingShingle | Kai Zhang Xuxiu Jing Guoqiang Wang MicroRNAs as regulators of drug abuse and immunity Central European Journal of Immunology <i>innate immunity microRNA immunity drug abuse adaptive immunity</i> |
| title | MicroRNAs as regulators of drug abuse and immunity |
| title_full | MicroRNAs as regulators of drug abuse and immunity |
| title_fullStr | MicroRNAs as regulators of drug abuse and immunity |
| title_full_unstemmed | MicroRNAs as regulators of drug abuse and immunity |
| title_short | MicroRNAs as regulators of drug abuse and immunity |
| title_sort | micrornas as regulators of drug abuse and immunity |
| topic | <i>innate immunity microRNA immunity drug abuse adaptive immunity</i> |
| url | https://www.termedia.pl/MicroRNAs-as-regulators-of-drug-abuse-and-immunity,10,29104,1,1.html |
| work_keys_str_mv | AT kaizhang micrornasasregulatorsofdrugabuseandimmunity AT xuxiujing micrornasasregulatorsofdrugabuseandimmunity AT guoqiangwang micrornasasregulatorsofdrugabuseandimmunity |