The Hormonal dysregulation and its consequences in Obese Women - overview
Introduction Obesity, a global health challenge, significantly impacts women's hormonal balance, affecting metabolic and reproductive health. Defined as a BMI >30 kg/m² by WHO, its prevalence is rising, creating substantial health and economic challenges. Aim of Study This study...
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| Format: | Article |
| Language: | English |
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Kazimierz Wielki University
2025-01-01
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| Series: | Journal of Education, Health and Sport |
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| Online Access: | https://apcz.umk.pl/JEHS/article/view/56907 |
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| author | Katarzyna Maria Pala Wiktoria Tomaszewska Paweł Siudziński Mateusz Łyko Alicja Skoczylas Maria Golińska Anna Nowak Jakub Kurasz Wiktoria Podlasiewicz Piotr Dudziak Wojciech Maj |
| author_facet | Katarzyna Maria Pala Wiktoria Tomaszewska Paweł Siudziński Mateusz Łyko Alicja Skoczylas Maria Golińska Anna Nowak Jakub Kurasz Wiktoria Podlasiewicz Piotr Dudziak Wojciech Maj |
| author_sort | Katarzyna Maria Pala |
| collection | DOAJ |
| description | Introduction
Obesity, a global health challenge, significantly impacts women's hormonal balance, affecting metabolic and reproductive health. Defined as a BMI >30 kg/m² by WHO, its prevalence is rising, creating substantial health and economic challenges.
Aim of Study
This study explores the effects of obesity on women's hormonal regulation, emphasizing associated conditions like PCOS, insulin resistance, infertility, and cardiometabolic diseases, while identifying mechanisms and potential interventions.
Material and Methods
A review of 34 peer-reviewed articles (2000–2024) using PRISMA criteria analyzed hormonal imbalances caused by obesity, focusing on adipokines such as leptin and adiponectin, and their roles in glucose metabolism, lipid regulation, and inflammation.
Analysis of Literature
Obesity-induced chronic inflammation disrupts insulin regulation, sex hormones, and the hypothalamic-pituitary-adrenal axis. It causes ovulatory disorders, reduced oocyte quality, and impaired endometrial receptivity. Mechanisms like insulin resistance, hyperandrogenism, and leptin dysfunction are central to these effects.
Conclusion
A multidimensional treatment approach, including lifestyle changes, pharmacotherapy (e.g., GLP-1 agonists), and surgical interventions, is essential. Personalized strategies can alleviate symptoms, improve metabolic and reproductive outcomes, and enhance quality of life for women with obesity.
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| format | Article |
| id | doaj-art-a340b227091f4c0c99353ce3fa9f1dfb |
| institution | Kabale University |
| issn | 2391-8306 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj-art-a340b227091f4c0c99353ce3fa9f1dfb2025-01-31T08:17:25ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062025-01-017710.12775/JEHS.2025.77.56907The Hormonal dysregulation and its consequences in Obese Women - overviewKatarzyna Maria Pala0https://orcid.org/0009-0004-0787-3872Wiktoria Tomaszewska1https://orcid.org/0009-0005-6166-1659Paweł Siudziński2https://orcid.org/0009-0002-4476-9412Mateusz Łyko3https://orcid.org/0009-0009-2530-2789Alicja Skoczylas4https://orcid.org/0009-0002-2185-5406Maria Golińska5https://orcid.org/0009-0008-2772-6131Anna Nowak6https://orcid.org/0009-0005-8833-1107Jakub Kurasz7https://orcid.org/0009-0004-3955-1552Wiktoria Podlasiewicz8https://orcid.org/0009-0001-6578-5297Piotr Dudziak9https://orcid.org/0009-0000-6173-740XWojciech Maj10https://orcid.org/0009-0003-2869-3718University of Opole plac Kopernika 11A, 45-040 OpoleUniversity of Opole plac Kopernika 11A, 45-040 OpoleUniversity of Opole plac Kopernika 11A, 45-040 OpoleUniversity of Opole plac Kopernika 11A, 45-040 OpoleUniversity of Opole plac Kopernika 11A, 45-040 OpoleUniversity of Opole plac Kopernika 11A, 45-040 OpoleUniversity of Opole plac Kopernika 11A, 45-040 OpoleUniversity of Opole plac Kopernika 11A, 45-040 OpoleWroclaw Medical University wybrzeże Ludwika Pasteura 1, 50-367 WrocławUniversity of Opole plac Kopernika 11A, 45-040 OpoleUniversity of Opole plac Kopernika 11A, 45-040 OpoleIntroduction Obesity, a global health challenge, significantly impacts women's hormonal balance, affecting metabolic and reproductive health. Defined as a BMI >30 kg/m² by WHO, its prevalence is rising, creating substantial health and economic challenges. Aim of Study This study explores the effects of obesity on women's hormonal regulation, emphasizing associated conditions like PCOS, insulin resistance, infertility, and cardiometabolic diseases, while identifying mechanisms and potential interventions. Material and Methods A review of 34 peer-reviewed articles (2000–2024) using PRISMA criteria analyzed hormonal imbalances caused by obesity, focusing on adipokines such as leptin and adiponectin, and their roles in glucose metabolism, lipid regulation, and inflammation. Analysis of Literature Obesity-induced chronic inflammation disrupts insulin regulation, sex hormones, and the hypothalamic-pituitary-adrenal axis. It causes ovulatory disorders, reduced oocyte quality, and impaired endometrial receptivity. Mechanisms like insulin resistance, hyperandrogenism, and leptin dysfunction are central to these effects. Conclusion A multidimensional treatment approach, including lifestyle changes, pharmacotherapy (e.g., GLP-1 agonists), and surgical interventions, is essential. Personalized strategies can alleviate symptoms, improve metabolic and reproductive outcomes, and enhance quality of life for women with obesity. https://apcz.umk.pl/JEHS/article/view/56907ObesityHormonal dysregulationInsulin resistanceAdipokinesLeptinAdiponectin |
| spellingShingle | Katarzyna Maria Pala Wiktoria Tomaszewska Paweł Siudziński Mateusz Łyko Alicja Skoczylas Maria Golińska Anna Nowak Jakub Kurasz Wiktoria Podlasiewicz Piotr Dudziak Wojciech Maj The Hormonal dysregulation and its consequences in Obese Women - overview Journal of Education, Health and Sport Obesity Hormonal dysregulation Insulin resistance Adipokines Leptin Adiponectin |
| title | The Hormonal dysregulation and its consequences in Obese Women - overview |
| title_full | The Hormonal dysregulation and its consequences in Obese Women - overview |
| title_fullStr | The Hormonal dysregulation and its consequences in Obese Women - overview |
| title_full_unstemmed | The Hormonal dysregulation and its consequences in Obese Women - overview |
| title_short | The Hormonal dysregulation and its consequences in Obese Women - overview |
| title_sort | hormonal dysregulation and its consequences in obese women overview |
| topic | Obesity Hormonal dysregulation Insulin resistance Adipokines Leptin Adiponectin |
| url | https://apcz.umk.pl/JEHS/article/view/56907 |
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