The Hormonal dysregulation and its consequences in Obese Women - overview

Introduction   Obesity, a global health challenge, significantly impacts women's hormonal balance, affecting metabolic and reproductive health. Defined as a BMI >30 kg/m² by WHO, its prevalence is rising, creating substantial health and economic challenges.   Aim of Study   This study...

Full description

Saved in:
Bibliographic Details
Main Authors: Katarzyna Maria Pala, Wiktoria Tomaszewska, Paweł Siudziński, Mateusz Łyko, Alicja Skoczylas, Maria Golińska, Anna Nowak, Jakub Kurasz, Wiktoria Podlasiewicz, Piotr Dudziak, Wojciech Maj
Format: Article
Language:English
Published: Kazimierz Wielki University 2025-01-01
Series:Journal of Education, Health and Sport
Subjects:
Online Access:https://apcz.umk.pl/JEHS/article/view/56907
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832576295245971456
author Katarzyna Maria Pala
Wiktoria Tomaszewska
Paweł Siudziński
Mateusz Łyko
Alicja Skoczylas
Maria Golińska
Anna Nowak
Jakub Kurasz
Wiktoria Podlasiewicz
Piotr Dudziak
Wojciech Maj
author_facet Katarzyna Maria Pala
Wiktoria Tomaszewska
Paweł Siudziński
Mateusz Łyko
Alicja Skoczylas
Maria Golińska
Anna Nowak
Jakub Kurasz
Wiktoria Podlasiewicz
Piotr Dudziak
Wojciech Maj
author_sort Katarzyna Maria Pala
collection DOAJ
description Introduction   Obesity, a global health challenge, significantly impacts women's hormonal balance, affecting metabolic and reproductive health. Defined as a BMI >30 kg/m² by WHO, its prevalence is rising, creating substantial health and economic challenges.   Aim of Study   This study explores the effects of obesity on women's hormonal regulation, emphasizing associated conditions like PCOS, insulin resistance, infertility, and cardiometabolic diseases, while identifying mechanisms and potential interventions.   Material and Methods   A review of 34 peer-reviewed articles (2000–2024) using PRISMA criteria analyzed hormonal imbalances caused by obesity, focusing on adipokines such as leptin and adiponectin, and their roles in glucose metabolism, lipid regulation, and inflammation.   Analysis of Literature Obesity-induced chronic inflammation disrupts insulin regulation, sex hormones, and the hypothalamic-pituitary-adrenal axis. It causes ovulatory disorders, reduced oocyte quality, and impaired endometrial receptivity. Mechanisms like insulin resistance, hyperandrogenism, and leptin dysfunction are central to these effects.   Conclusion   A multidimensional treatment approach, including lifestyle changes, pharmacotherapy (e.g., GLP-1 agonists), and surgical interventions, is essential. Personalized strategies can alleviate symptoms, improve metabolic and reproductive outcomes, and enhance quality of life for women with obesity.
format Article
id doaj-art-a340b227091f4c0c99353ce3fa9f1dfb
institution Kabale University
issn 2391-8306
language English
publishDate 2025-01-01
publisher Kazimierz Wielki University
record_format Article
series Journal of Education, Health and Sport
spelling doaj-art-a340b227091f4c0c99353ce3fa9f1dfb2025-01-31T08:17:25ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062025-01-017710.12775/JEHS.2025.77.56907The Hormonal dysregulation and its consequences in Obese Women - overviewKatarzyna Maria Pala0https://orcid.org/0009-0004-0787-3872Wiktoria Tomaszewska1https://orcid.org/0009-0005-6166-1659Paweł Siudziński2https://orcid.org/0009-0002-4476-9412Mateusz Łyko3https://orcid.org/0009-0009-2530-2789Alicja Skoczylas4https://orcid.org/0009-0002-2185-5406Maria Golińska5https://orcid.org/0009-0008-2772-6131Anna Nowak6https://orcid.org/0009-0005-8833-1107Jakub Kurasz7https://orcid.org/0009-0004-3955-1552Wiktoria Podlasiewicz8https://orcid.org/0009-0001-6578-5297Piotr Dudziak9https://orcid.org/0009-0000-6173-740XWojciech Maj10https://orcid.org/0009-0003-2869-3718University of Opole plac Kopernika 11A, 45-040 OpoleUniversity of Opole plac Kopernika 11A, 45-040 OpoleUniversity of Opole plac Kopernika 11A, 45-040 OpoleUniversity of Opole plac Kopernika 11A, 45-040 OpoleUniversity of Opole plac Kopernika 11A, 45-040 OpoleUniversity of Opole plac Kopernika 11A, 45-040 OpoleUniversity of Opole plac Kopernika 11A, 45-040 OpoleUniversity of Opole plac Kopernika 11A, 45-040 OpoleWroclaw Medical University wybrzeże Ludwika Pasteura 1, 50-367 WrocławUniversity of Opole plac Kopernika 11A, 45-040 OpoleUniversity of Opole plac Kopernika 11A, 45-040 OpoleIntroduction   Obesity, a global health challenge, significantly impacts women's hormonal balance, affecting metabolic and reproductive health. Defined as a BMI >30 kg/m² by WHO, its prevalence is rising, creating substantial health and economic challenges.   Aim of Study   This study explores the effects of obesity on women's hormonal regulation, emphasizing associated conditions like PCOS, insulin resistance, infertility, and cardiometabolic diseases, while identifying mechanisms and potential interventions.   Material and Methods   A review of 34 peer-reviewed articles (2000–2024) using PRISMA criteria analyzed hormonal imbalances caused by obesity, focusing on adipokines such as leptin and adiponectin, and their roles in glucose metabolism, lipid regulation, and inflammation.   Analysis of Literature Obesity-induced chronic inflammation disrupts insulin regulation, sex hormones, and the hypothalamic-pituitary-adrenal axis. It causes ovulatory disorders, reduced oocyte quality, and impaired endometrial receptivity. Mechanisms like insulin resistance, hyperandrogenism, and leptin dysfunction are central to these effects.   Conclusion   A multidimensional treatment approach, including lifestyle changes, pharmacotherapy (e.g., GLP-1 agonists), and surgical interventions, is essential. Personalized strategies can alleviate symptoms, improve metabolic and reproductive outcomes, and enhance quality of life for women with obesity. https://apcz.umk.pl/JEHS/article/view/56907ObesityHormonal dysregulationInsulin resistanceAdipokinesLeptinAdiponectin
spellingShingle Katarzyna Maria Pala
Wiktoria Tomaszewska
Paweł Siudziński
Mateusz Łyko
Alicja Skoczylas
Maria Golińska
Anna Nowak
Jakub Kurasz
Wiktoria Podlasiewicz
Piotr Dudziak
Wojciech Maj
The Hormonal dysregulation and its consequences in Obese Women - overview
Journal of Education, Health and Sport
Obesity
Hormonal dysregulation
Insulin resistance
Adipokines
Leptin
Adiponectin
title The Hormonal dysregulation and its consequences in Obese Women - overview
title_full The Hormonal dysregulation and its consequences in Obese Women - overview
title_fullStr The Hormonal dysregulation and its consequences in Obese Women - overview
title_full_unstemmed The Hormonal dysregulation and its consequences in Obese Women - overview
title_short The Hormonal dysregulation and its consequences in Obese Women - overview
title_sort hormonal dysregulation and its consequences in obese women overview
topic Obesity
Hormonal dysregulation
Insulin resistance
Adipokines
Leptin
Adiponectin
url https://apcz.umk.pl/JEHS/article/view/56907
work_keys_str_mv AT katarzynamariapala thehormonaldysregulationanditsconsequencesinobesewomenoverview
AT wiktoriatomaszewska thehormonaldysregulationanditsconsequencesinobesewomenoverview
AT pawełsiudzinski thehormonaldysregulationanditsconsequencesinobesewomenoverview
AT mateuszłyko thehormonaldysregulationanditsconsequencesinobesewomenoverview
AT alicjaskoczylas thehormonaldysregulationanditsconsequencesinobesewomenoverview
AT mariagolinska thehormonaldysregulationanditsconsequencesinobesewomenoverview
AT annanowak thehormonaldysregulationanditsconsequencesinobesewomenoverview
AT jakubkurasz thehormonaldysregulationanditsconsequencesinobesewomenoverview
AT wiktoriapodlasiewicz thehormonaldysregulationanditsconsequencesinobesewomenoverview
AT piotrdudziak thehormonaldysregulationanditsconsequencesinobesewomenoverview
AT wojciechmaj thehormonaldysregulationanditsconsequencesinobesewomenoverview
AT katarzynamariapala hormonaldysregulationanditsconsequencesinobesewomenoverview
AT wiktoriatomaszewska hormonaldysregulationanditsconsequencesinobesewomenoverview
AT pawełsiudzinski hormonaldysregulationanditsconsequencesinobesewomenoverview
AT mateuszłyko hormonaldysregulationanditsconsequencesinobesewomenoverview
AT alicjaskoczylas hormonaldysregulationanditsconsequencesinobesewomenoverview
AT mariagolinska hormonaldysregulationanditsconsequencesinobesewomenoverview
AT annanowak hormonaldysregulationanditsconsequencesinobesewomenoverview
AT jakubkurasz hormonaldysregulationanditsconsequencesinobesewomenoverview
AT wiktoriapodlasiewicz hormonaldysregulationanditsconsequencesinobesewomenoverview
AT piotrdudziak hormonaldysregulationanditsconsequencesinobesewomenoverview
AT wojciechmaj hormonaldysregulationanditsconsequencesinobesewomenoverview