Retrobulbar Hemodynamic Effects of Nipradilol in Normal and Normal-Tension Glaucoma Eyes
Purpose. To investigate the effects of nipradilol on retrobulbar hemodynamics. Methods. We investigated normal and normal-tension glaucoma (NTG) eyes. Topical nipradilol (one eye) and placebo eye drops (fellow eye) were instilled for 1 week in volunteers. Nipradilol was also instilled in NTG patient...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2011/652904 |
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| author | Mitsushi Fukukita Masashi Ido Syunsuke Osawa Mikio Sasoh Motoyasu Furuta Kunio Ito Masahiko Sugimoto Yukitaka Uji |
| author_facet | Mitsushi Fukukita Masashi Ido Syunsuke Osawa Mikio Sasoh Motoyasu Furuta Kunio Ito Masahiko Sugimoto Yukitaka Uji |
| author_sort | Mitsushi Fukukita |
| collection | DOAJ |
| description | Purpose. To investigate the effects of nipradilol on retrobulbar hemodynamics. Methods. We investigated normal and normal-tension glaucoma (NTG) eyes. Topical nipradilol (one eye) and placebo eye drops (fellow eye) were instilled for 1 week in volunteers. Nipradilol was also instilled in NTG patients. Ultrasound color Doppler imaging for the posterior vessels was performed before, 2 hr, 1 week (for normal), and at 4 weeks (for NTG). Results. In normal eyes, there were significant decreases in the resistance index (RI) for the temporal short posterior ciliary arteries (PCA) at 2 hr and for the ophthalmic arteries at 1 week. There were no significant changes in the placebo-treated eyes. In the NTG eyes, there was a significant decrease in the RI for the central retinal artery, nasal, and temporal PCA at 2 hr and 4 weeks. Conclusion. Short-term observations found that nipradilol increased the ocular blood flow in normal and NTG eyes. |
| format | Article |
| id | doaj-art-a33bc5a91d1240279302e1617c6ff1f9 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-a33bc5a91d1240279302e1617c6ff1f92025-02-03T01:03:19ZengWileyJournal of Ophthalmology2090-004X2090-00582011-01-01201110.1155/2011/652904652904Retrobulbar Hemodynamic Effects of Nipradilol in Normal and Normal-Tension Glaucoma EyesMitsushi Fukukita0Masashi Ido1Syunsuke Osawa2Mikio Sasoh3Motoyasu Furuta4Kunio Ito5Masahiko Sugimoto6Yukitaka Uji7Department of Ophthalmology, Mie University School of Medicine, Mie 514-8507, JapanDepartment of Ophthalmology, Mie University School of Medicine, Mie 514-8507, JapanDepartment of Ophthalmology, Mie University School of Medicine, Mie 514-8507, JapanDepartment of Ophthalmology, Mie University School of Medicine, Mie 514-8507, JapanDepartment of Ophthalmology, Mie University School of Medicine, Mie 514-8507, JapanDepartment of Ophthalmology, Mie University School of Medicine, Mie 514-8507, JapanDepartment of Ophthalmology, Mie University School of Medicine, Mie 514-8507, JapanDepartment of Ophthalmology, Mie University School of Medicine, Mie 514-8507, JapanPurpose. To investigate the effects of nipradilol on retrobulbar hemodynamics. Methods. We investigated normal and normal-tension glaucoma (NTG) eyes. Topical nipradilol (one eye) and placebo eye drops (fellow eye) were instilled for 1 week in volunteers. Nipradilol was also instilled in NTG patients. Ultrasound color Doppler imaging for the posterior vessels was performed before, 2 hr, 1 week (for normal), and at 4 weeks (for NTG). Results. In normal eyes, there were significant decreases in the resistance index (RI) for the temporal short posterior ciliary arteries (PCA) at 2 hr and for the ophthalmic arteries at 1 week. There were no significant changes in the placebo-treated eyes. In the NTG eyes, there was a significant decrease in the RI for the central retinal artery, nasal, and temporal PCA at 2 hr and 4 weeks. Conclusion. Short-term observations found that nipradilol increased the ocular blood flow in normal and NTG eyes.http://dx.doi.org/10.1155/2011/652904 |
| spellingShingle | Mitsushi Fukukita Masashi Ido Syunsuke Osawa Mikio Sasoh Motoyasu Furuta Kunio Ito Masahiko Sugimoto Yukitaka Uji Retrobulbar Hemodynamic Effects of Nipradilol in Normal and Normal-Tension Glaucoma Eyes Journal of Ophthalmology |
| title | Retrobulbar Hemodynamic Effects of Nipradilol in Normal and Normal-Tension Glaucoma Eyes |
| title_full | Retrobulbar Hemodynamic Effects of Nipradilol in Normal and Normal-Tension Glaucoma Eyes |
| title_fullStr | Retrobulbar Hemodynamic Effects of Nipradilol in Normal and Normal-Tension Glaucoma Eyes |
| title_full_unstemmed | Retrobulbar Hemodynamic Effects of Nipradilol in Normal and Normal-Tension Glaucoma Eyes |
| title_short | Retrobulbar Hemodynamic Effects of Nipradilol in Normal and Normal-Tension Glaucoma Eyes |
| title_sort | retrobulbar hemodynamic effects of nipradilol in normal and normal tension glaucoma eyes |
| url | http://dx.doi.org/10.1155/2011/652904 |
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