Lipid and Bile Acid Dysmetabolism in Crohn’s Disease
Crohn’s disease is one of the systemic autoimmune diseases. It commonly affects the small intestine and colon but may involve any portion of the gastrointestinal tract from the mouth to the anus. The most affected area by Crohn’s disease is the distal part of the small intestine, in which the bile a...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/7270486 |
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| author | Koji Uchiyama Hisashi Kishi Wataru Komatsu Masanori Nagao Shuji Ohhira Gen Kobashi |
| author_facet | Koji Uchiyama Hisashi Kishi Wataru Komatsu Masanori Nagao Shuji Ohhira Gen Kobashi |
| author_sort | Koji Uchiyama |
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| description | Crohn’s disease is one of the systemic autoimmune diseases. It commonly affects the small intestine and colon but may involve any portion of the gastrointestinal tract from the mouth to the anus. The most affected area by Crohn’s disease is the distal part of the small intestine, in which the bile acid molecules are most efficiently reabsorbed. Bile acids form mixed micelles together with fatty acids, which function as a transport vehicle to deliver fatty acids to the apical membrane of enterocytes for absorption. Therefore, if the terminal ileum is impaired, bile acid malabsorption may occur, which may cause congenital diarrhoea in Crohn’s disease. Similarly, the impairment of the terminal ileum also induces fatty acid malabsorption, which may influence the role of fatty acids in Crohn’s disease. In contrast, a recent study reported that multidrug resistance protein 1 (MDR1) regulated effector T-cell function in the ileum from bile acid-driven oxidative stress and MDR1 loss of function in a subset of patients with Crohn’s disease. However, the role of consumption of fatty acids in Crohn’s disease remains to be fully elucidated. This review is aimed at providing an overview of some recent developments in research of Crohn’s disease from comprehensive perspective with a focus on the connection between disease location and behaviour, lipid diets, and bile acid malabsorption. |
| format | Article |
| id | doaj-art-a320f7630ad74e30b1000143641212f3 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-a320f7630ad74e30b1000143641212f32025-02-03T01:20:03ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/72704867270486Lipid and Bile Acid Dysmetabolism in Crohn’s DiseaseKoji Uchiyama0Hisashi Kishi1Wataru Komatsu2Masanori Nagao3Shuji Ohhira4Gen Kobashi5Laboratory of International Environmental Health, Center for International Cooperation, Dokkyo Medical University, Tochigi 321-0293, JapanLaboratory of International Environmental Health, Center for International Cooperation, Dokkyo Medical University, Tochigi 321-0293, JapanLaboratory of International Environmental Health, Center for International Cooperation, Dokkyo Medical University, Tochigi 321-0293, JapanDepartment of Public Health, Dokkyo Medical University School of Medicine, Tochigi 321-0293, JapanLaboratory of International Environmental Health, Center for International Cooperation, Dokkyo Medical University, Tochigi 321-0293, JapanDepartment of Public Health, Dokkyo Medical University School of Medicine, Tochigi 321-0293, JapanCrohn’s disease is one of the systemic autoimmune diseases. It commonly affects the small intestine and colon but may involve any portion of the gastrointestinal tract from the mouth to the anus. The most affected area by Crohn’s disease is the distal part of the small intestine, in which the bile acid molecules are most efficiently reabsorbed. Bile acids form mixed micelles together with fatty acids, which function as a transport vehicle to deliver fatty acids to the apical membrane of enterocytes for absorption. Therefore, if the terminal ileum is impaired, bile acid malabsorption may occur, which may cause congenital diarrhoea in Crohn’s disease. Similarly, the impairment of the terminal ileum also induces fatty acid malabsorption, which may influence the role of fatty acids in Crohn’s disease. In contrast, a recent study reported that multidrug resistance protein 1 (MDR1) regulated effector T-cell function in the ileum from bile acid-driven oxidative stress and MDR1 loss of function in a subset of patients with Crohn’s disease. However, the role of consumption of fatty acids in Crohn’s disease remains to be fully elucidated. This review is aimed at providing an overview of some recent developments in research of Crohn’s disease from comprehensive perspective with a focus on the connection between disease location and behaviour, lipid diets, and bile acid malabsorption.http://dx.doi.org/10.1155/2018/7270486 |
| spellingShingle | Koji Uchiyama Hisashi Kishi Wataru Komatsu Masanori Nagao Shuji Ohhira Gen Kobashi Lipid and Bile Acid Dysmetabolism in Crohn’s Disease Journal of Immunology Research |
| title | Lipid and Bile Acid Dysmetabolism in Crohn’s Disease |
| title_full | Lipid and Bile Acid Dysmetabolism in Crohn’s Disease |
| title_fullStr | Lipid and Bile Acid Dysmetabolism in Crohn’s Disease |
| title_full_unstemmed | Lipid and Bile Acid Dysmetabolism in Crohn’s Disease |
| title_short | Lipid and Bile Acid Dysmetabolism in Crohn’s Disease |
| title_sort | lipid and bile acid dysmetabolism in crohn s disease |
| url | http://dx.doi.org/10.1155/2018/7270486 |
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