Excess Early Postnatal Weight Gain Leads to Increased Abdominal Fat in Young Children
Background. Increased childhood weight gain has been associated with later adiposity. Whether excess early postnatal weight gain plays a role in childhood abdominal fat is unknown. Design. In the ongoing Wheezing Illnesses Study Leidsche Rijn (WHISTLER), birth cohort weight and length from birth to...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2012/141656 |
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| author | Annemieke M. V. Evelein Frank L. J. Visseren Cornelis K. van der Ent Diederick E. Grobbee Cuno S. P. M. Uiterwaal |
| author_facet | Annemieke M. V. Evelein Frank L. J. Visseren Cornelis K. van der Ent Diederick E. Grobbee Cuno S. P. M. Uiterwaal |
| author_sort | Annemieke M. V. Evelein |
| collection | DOAJ |
| description | Background. Increased childhood weight gain has been associated with later adiposity. Whether excess early postnatal weight gain plays a role in childhood abdominal fat is unknown. Design. In the ongoing Wheezing Illnesses Study Leidsche Rijn (WHISTLER), birth cohort weight and length from birth to age 3 months were obtained. In the first 316 five-year-olds, intra-abdominal and subcutaneous fat were measured ultrasonographically. Individual weight and length gain rates were assessed in each child. Internal Z-scores of weight for length gain (WLG) were calculated. Multiple imputation was used to deal with missing covariates. Results. Per-1-unit increase in Z-score WLG from birth to 3 months, BMI, waist circumference, and subcutaneous fat were significantly higher; 0.51 kg/m2, 0.84 cm, and 0.50 mm, respectively. After multiple imputation, a trend towards significance was observed for intra-abdominal fat as well (0.51 mm/SD). In the associations with 5-year adiposity, no interaction between postnatal Z-score WLG and birth size was found. Conclusion. Excess early postnatal weight gain is associated with increased general and central adiposity, characterized by more subcutaneous and likely more intra-abdominal fat at 5 years of age. |
| format | Article |
| id | doaj-art-a30f265ba20e472ab4e7c75e882cf099 |
| institution | Kabale University |
| issn | 1687-9740 1687-9759 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj-art-a30f265ba20e472ab4e7c75e882cf0992025-02-03T01:26:32ZengWileyInternational Journal of Pediatrics1687-97401687-97592012-01-01201210.1155/2012/141656141656Excess Early Postnatal Weight Gain Leads to Increased Abdominal Fat in Young ChildrenAnnemieke M. V. Evelein0Frank L. J. Visseren1Cornelis K. van der Ent2Diederick E. Grobbee3Cuno S. P. M. Uiterwaal4Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, P.O. Box 85060, Utrecht, The NetherlandsDepartment of Vascular Medicine, University Medical Center Utrecht, P.O. Box 85500, Utrecht, The NetherlandsDepartment of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, P.O. Box 85090, Utrecht, The NetherlandsJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, P.O. Box 85060, Utrecht, The NetherlandsJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, P.O. Box 85060, Utrecht, The NetherlandsBackground. Increased childhood weight gain has been associated with later adiposity. Whether excess early postnatal weight gain plays a role in childhood abdominal fat is unknown. Design. In the ongoing Wheezing Illnesses Study Leidsche Rijn (WHISTLER), birth cohort weight and length from birth to age 3 months were obtained. In the first 316 five-year-olds, intra-abdominal and subcutaneous fat were measured ultrasonographically. Individual weight and length gain rates were assessed in each child. Internal Z-scores of weight for length gain (WLG) were calculated. Multiple imputation was used to deal with missing covariates. Results. Per-1-unit increase in Z-score WLG from birth to 3 months, BMI, waist circumference, and subcutaneous fat were significantly higher; 0.51 kg/m2, 0.84 cm, and 0.50 mm, respectively. After multiple imputation, a trend towards significance was observed for intra-abdominal fat as well (0.51 mm/SD). In the associations with 5-year adiposity, no interaction between postnatal Z-score WLG and birth size was found. Conclusion. Excess early postnatal weight gain is associated with increased general and central adiposity, characterized by more subcutaneous and likely more intra-abdominal fat at 5 years of age.http://dx.doi.org/10.1155/2012/141656 |
| spellingShingle | Annemieke M. V. Evelein Frank L. J. Visseren Cornelis K. van der Ent Diederick E. Grobbee Cuno S. P. M. Uiterwaal Excess Early Postnatal Weight Gain Leads to Increased Abdominal Fat in Young Children International Journal of Pediatrics |
| title | Excess Early Postnatal Weight Gain Leads to Increased Abdominal Fat in Young Children |
| title_full | Excess Early Postnatal Weight Gain Leads to Increased Abdominal Fat in Young Children |
| title_fullStr | Excess Early Postnatal Weight Gain Leads to Increased Abdominal Fat in Young Children |
| title_full_unstemmed | Excess Early Postnatal Weight Gain Leads to Increased Abdominal Fat in Young Children |
| title_short | Excess Early Postnatal Weight Gain Leads to Increased Abdominal Fat in Young Children |
| title_sort | excess early postnatal weight gain leads to increased abdominal fat in young children |
| url | http://dx.doi.org/10.1155/2012/141656 |
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