Study on the Interaction of Serum Albumin and Micromolecule Compounds
Fluorescence spectrometry is a classical and conventional technique widely used in interaction investigation, which takes serum albumin as the fluorescence source while micro-molecule compound as the quencher. With analyzing the properties of serum albumin and its amino acids, deficiencies in the co...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2012/319615 |
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| _version_ | 1832548692982235136 |
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| author | Rui Huang Zhi-Ning Xia Min Yi Bo-Lin Liu |
| author_facet | Rui Huang Zhi-Ning Xia Min Yi Bo-Lin Liu |
| author_sort | Rui Huang |
| collection | DOAJ |
| description | Fluorescence spectrometry is a classical and conventional technique widely used in interaction investigation, which takes serum albumin as the fluorescence source while micro-molecule compound as the quencher. With analyzing the properties of serum albumin and its amino acids, deficiencies in the conventional fluorescence spectrometry became obvious: information expressed by the conventional technique was not sufficient to represent the entire interaction. In consideration of that, a new method was proposed to improve the conventional one. Intercompared the experimental results of those two methods, defects of the conventional fluorescence spectrometry were noticeable. In addition, molecular docking simulation and binding force investigation also manifested the same as above. |
| format | Article |
| id | doaj-art-a30f0fe7316b4503ba02669b146bd77a |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-a30f0fe7316b4503ba02669b146bd77a2025-02-03T06:13:20ZengWileyE-Journal of Chemistry0973-49452090-98102012-01-01941951195910.1155/2012/319615Study on the Interaction of Serum Albumin and Micromolecule CompoundsRui Huang0Zhi-Ning Xia1Min Yi2Bo-Lin Liu3College of Bioengineering, Chongqing University, Chongqing 400044, ChinaCollege of Bioengineering, Chongqing University, Chongqing 400044, ChinaCollege of Criminal Investigation Law, Southwest University of Political Science and Law, Chongqing 401120, ChinaCollege of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400044, ChinaFluorescence spectrometry is a classical and conventional technique widely used in interaction investigation, which takes serum albumin as the fluorescence source while micro-molecule compound as the quencher. With analyzing the properties of serum albumin and its amino acids, deficiencies in the conventional fluorescence spectrometry became obvious: information expressed by the conventional technique was not sufficient to represent the entire interaction. In consideration of that, a new method was proposed to improve the conventional one. Intercompared the experimental results of those two methods, defects of the conventional fluorescence spectrometry were noticeable. In addition, molecular docking simulation and binding force investigation also manifested the same as above.http://dx.doi.org/10.1155/2012/319615 |
| spellingShingle | Rui Huang Zhi-Ning Xia Min Yi Bo-Lin Liu Study on the Interaction of Serum Albumin and Micromolecule Compounds E-Journal of Chemistry |
| title | Study on the Interaction of Serum Albumin and Micromolecule Compounds |
| title_full | Study on the Interaction of Serum Albumin and Micromolecule Compounds |
| title_fullStr | Study on the Interaction of Serum Albumin and Micromolecule Compounds |
| title_full_unstemmed | Study on the Interaction of Serum Albumin and Micromolecule Compounds |
| title_short | Study on the Interaction of Serum Albumin and Micromolecule Compounds |
| title_sort | study on the interaction of serum albumin and micromolecule compounds |
| url | http://dx.doi.org/10.1155/2012/319615 |
| work_keys_str_mv | AT ruihuang studyontheinteractionofserumalbuminandmicromoleculecompounds AT zhiningxia studyontheinteractionofserumalbuminandmicromoleculecompounds AT minyi studyontheinteractionofserumalbuminandmicromoleculecompounds AT bolinliu studyontheinteractionofserumalbuminandmicromoleculecompounds |