GLI2-HRD1 axis facilitates 5-FU resistance in gastric cancer cells by regulating ubiquitination degradation of UCK2

GLI2-HRD1 axis facilitates 5-FU resistance in gastric cancer cells by regulating ubiquitination degradation of UCK2

5-Fluorouracil (5-FU) is a primary chemotherapeutic agent for treating gastric cancer (GC), yet resistance to 5-FU frequently limits its effectiveness and contributes to poor patient outcomes. This study investigated the molecular mechanisms by which uridine-cytidine kinase 2 (UCK2) influences 5-FU...

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Bibliographic Details
Main Authors: Chaorong Xue, Xuanzi Zhang, Wanling Yu, Hanbin Lin, Junrong Zhang, Jiawen Liu, Zongqi Weng, Manduo Ouyang, Xinjian Lin
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Translational Oncology
Subjects:
5-FU resistance
Gastric cancer
UCK2
GLI2
HRD1
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523325001548
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