Atypical pulmonary manifestations suggestive of lung cancer in behçet’s disease with spontaneously regressing lymphadenopathy and a lung mass: a case report
Abstract Background Behçet’s disease (BD) is a multisystem inflammatory disorder that can affect various organs, including the lungs. Pulmonary manifestations are rare and typically present as pulmonary artery aneurysms. Case presentation We report the case of a 56-year-old East Asian male with a 27...
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BMC
2025-01-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | https://doi.org/10.1186/s12890-025-03494-3 |
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| author | So-yun Kim Min-kyung Yeo Subin Im Chaeuk Chung |
| author_facet | So-yun Kim Min-kyung Yeo Subin Im Chaeuk Chung |
| author_sort | So-yun Kim |
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| description | Abstract Background Behçet’s disease (BD) is a multisystem inflammatory disorder that can affect various organs, including the lungs. Pulmonary manifestations are rare and typically present as pulmonary artery aneurysms. Case presentation We report the case of a 56-year-old East Asian male with a 27-year history of BD, who had no respiratory symptoms, such as hemoptysis, cough, or fever. Chest imaging revealed lymph node enlargement and a lung mass, initially raising concerns of malignancy. Despite the suspicious radiological findings, three biopsies, including a surgical biopsy, were all negative for malignancy. Remarkably, over the course of 2 years, these pulmonary manifestations spontaneously regressed without any specific treatment for lung involvement, and the patient remained in a stable BD state. Conclusions BD patients are at an increased risk for malignancy compared to healthy controls, making it crucial to differentiate between malignancy and BD-related pulmonary abnormalities. This case highlights that, in the absence of active BD symptoms, lymphadenopathy and lung masses can occur and may resolve spontaneously. Accurate diagnosis and vigilant monitoring are essential in BD patients but BD-related lung involvement should be considered in similar cases. |
| format | Article |
| id | doaj-art-a30675366ff24d019d4cdbab7cbfd3b0 |
| institution | Kabale University |
| issn | 1471-2466 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj-art-a30675366ff24d019d4cdbab7cbfd3b02025-01-19T12:08:22ZengBMCBMC Pulmonary Medicine1471-24662025-01-012511810.1186/s12890-025-03494-3Atypical pulmonary manifestations suggestive of lung cancer in behçet’s disease with spontaneously regressing lymphadenopathy and a lung mass: a case reportSo-yun Kim0Min-kyung Yeo1Subin Im2Chaeuk Chung3Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, College of Medicine, Chungnam National UniversityDepartment of pathology, College of Medicine, Chungnam National UniversityCollege of Medicine, Chungnam National UniversityDivision of Pulmonology and Critical Care Medicine, Department of Internal Medicine, College of Medicine, Chungnam National UniversityAbstract Background Behçet’s disease (BD) is a multisystem inflammatory disorder that can affect various organs, including the lungs. Pulmonary manifestations are rare and typically present as pulmonary artery aneurysms. Case presentation We report the case of a 56-year-old East Asian male with a 27-year history of BD, who had no respiratory symptoms, such as hemoptysis, cough, or fever. Chest imaging revealed lymph node enlargement and a lung mass, initially raising concerns of malignancy. Despite the suspicious radiological findings, three biopsies, including a surgical biopsy, were all negative for malignancy. Remarkably, over the course of 2 years, these pulmonary manifestations spontaneously regressed without any specific treatment for lung involvement, and the patient remained in a stable BD state. Conclusions BD patients are at an increased risk for malignancy compared to healthy controls, making it crucial to differentiate between malignancy and BD-related pulmonary abnormalities. This case highlights that, in the absence of active BD symptoms, lymphadenopathy and lung masses can occur and may resolve spontaneously. Accurate diagnosis and vigilant monitoring are essential in BD patients but BD-related lung involvement should be considered in similar cases.https://doi.org/10.1186/s12890-025-03494-3Behçet’s diseaseLymphadenopathyLung massPulmonary manifestationRegression |
| spellingShingle | So-yun Kim Min-kyung Yeo Subin Im Chaeuk Chung Atypical pulmonary manifestations suggestive of lung cancer in behçet’s disease with spontaneously regressing lymphadenopathy and a lung mass: a case report BMC Pulmonary Medicine Behçet’s disease Lymphadenopathy Lung mass Pulmonary manifestation Regression |
| title | Atypical pulmonary manifestations suggestive of lung cancer in behçet’s disease with spontaneously regressing lymphadenopathy and a lung mass: a case report |
| title_full | Atypical pulmonary manifestations suggestive of lung cancer in behçet’s disease with spontaneously regressing lymphadenopathy and a lung mass: a case report |
| title_fullStr | Atypical pulmonary manifestations suggestive of lung cancer in behçet’s disease with spontaneously regressing lymphadenopathy and a lung mass: a case report |
| title_full_unstemmed | Atypical pulmonary manifestations suggestive of lung cancer in behçet’s disease with spontaneously regressing lymphadenopathy and a lung mass: a case report |
| title_short | Atypical pulmonary manifestations suggestive of lung cancer in behçet’s disease with spontaneously regressing lymphadenopathy and a lung mass: a case report |
| title_sort | atypical pulmonary manifestations suggestive of lung cancer in behcet s disease with spontaneously regressing lymphadenopathy and a lung mass a case report |
| topic | Behçet’s disease Lymphadenopathy Lung mass Pulmonary manifestation Regression |
| url | https://doi.org/10.1186/s12890-025-03494-3 |
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