Formulation and Evaluation of Guggul Lipid Nanovesicles for Transdermal Delivery of Aceclofenac
Context. Most new drugs have low water solubility and liposome is an important formulation to administer such drugs; however, it is quite unstable and has negligible systemic absorption. Objective. Aceclofenac nanovesicles were made using guggul lipid for formulating stable transdermal formulation....
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| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/534210 |
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| author | Praveen Kumar Gaur Shikha Mishra Vidhu Aeri |
| author_facet | Praveen Kumar Gaur Shikha Mishra Vidhu Aeri |
| author_sort | Praveen Kumar Gaur |
| collection | DOAJ |
| description | Context. Most new drugs have low water solubility and liposome is an important formulation to administer such drugs; however, it is quite unstable and has negligible systemic absorption. Objective. Aceclofenac nanovesicles were made using guggul lipid for formulating stable transdermal formulation. Materials and Methods. Guggul lipid was formulated into vesicles along with cholesterol and dicetyl phosphate using film hydration method. The formulations were analyzed for physicochemical properties and stability. Then its skin permeation and anti-inflammatory activity were determined. Results. Both categories of vesicles (PC and GL) showed optimum physicochemical properties; however, accelerated stability study showed considerable differences. GL-1 was appreciably stable for over 6 months at 4°C. Corresponding gels (PCG-1 and GLG-1) showed Cmax values at 4.98 and 7.32 μg/mL along with the Tmax values at 4 and 8 hours, respectively. GLG-1 inhibited edema production by 90.81% in 6 hours. Discussion. PC liposomes are unstable at higher temperature and upon longer storage. The formulation with higher lipid content (GL-1) showed good drug retention after 24 hours and appreciable stability both at higher temperature and for longer duration. Guggul lipid being a planar molecule might be stacked in vesicle wall with cholesterol. Conclusion. The composition of the nanovesicle played an important role in stability and drug permeation. Guggul lipid is suitable for producing stable vesicles. |
| format | Article |
| id | doaj-art-a303ecbade204e0596471e14ffc4e815 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-a303ecbade204e0596471e14ffc4e8152025-02-03T05:46:16ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/534210534210Formulation and Evaluation of Guggul Lipid Nanovesicles for Transdermal Delivery of AceclofenacPraveen Kumar Gaur0Shikha Mishra1Vidhu Aeri2Department of Pharmaceutics, I.T.S. Paramedical (Pharmacy) College, Muradnagar, Ghaziabad 201206, IndiaDepartment of Pharmacognosy & Phytochemistry, Jamia Hamdard, New Delhi 110062, IndiaDepartment of Pharmacognosy & Phytochemistry, Jamia Hamdard, New Delhi 110062, IndiaContext. Most new drugs have low water solubility and liposome is an important formulation to administer such drugs; however, it is quite unstable and has negligible systemic absorption. Objective. Aceclofenac nanovesicles were made using guggul lipid for formulating stable transdermal formulation. Materials and Methods. Guggul lipid was formulated into vesicles along with cholesterol and dicetyl phosphate using film hydration method. The formulations were analyzed for physicochemical properties and stability. Then its skin permeation and anti-inflammatory activity were determined. Results. Both categories of vesicles (PC and GL) showed optimum physicochemical properties; however, accelerated stability study showed considerable differences. GL-1 was appreciably stable for over 6 months at 4°C. Corresponding gels (PCG-1 and GLG-1) showed Cmax values at 4.98 and 7.32 μg/mL along with the Tmax values at 4 and 8 hours, respectively. GLG-1 inhibited edema production by 90.81% in 6 hours. Discussion. PC liposomes are unstable at higher temperature and upon longer storage. The formulation with higher lipid content (GL-1) showed good drug retention after 24 hours and appreciable stability both at higher temperature and for longer duration. Guggul lipid being a planar molecule might be stacked in vesicle wall with cholesterol. Conclusion. The composition of the nanovesicle played an important role in stability and drug permeation. Guggul lipid is suitable for producing stable vesicles.http://dx.doi.org/10.1155/2014/534210 |
| spellingShingle | Praveen Kumar Gaur Shikha Mishra Vidhu Aeri Formulation and Evaluation of Guggul Lipid Nanovesicles for Transdermal Delivery of Aceclofenac The Scientific World Journal |
| title | Formulation and Evaluation of Guggul Lipid Nanovesicles for Transdermal Delivery of Aceclofenac |
| title_full | Formulation and Evaluation of Guggul Lipid Nanovesicles for Transdermal Delivery of Aceclofenac |
| title_fullStr | Formulation and Evaluation of Guggul Lipid Nanovesicles for Transdermal Delivery of Aceclofenac |
| title_full_unstemmed | Formulation and Evaluation of Guggul Lipid Nanovesicles for Transdermal Delivery of Aceclofenac |
| title_short | Formulation and Evaluation of Guggul Lipid Nanovesicles for Transdermal Delivery of Aceclofenac |
| title_sort | formulation and evaluation of guggul lipid nanovesicles for transdermal delivery of aceclofenac |
| url | http://dx.doi.org/10.1155/2014/534210 |
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