Development and Statistical Validation of Spectrophotometric Methods for the Estimation of Nabumetone in Tablet Dosage Form
Three new simple, economic spectrophotometric methods were developed and validated for the estimation of nabumetone in bulk and tablet dosage form. First method includes determination of nabumetone at absorption maxima 330 nm, second method applied was area under curve for analysis of nabumetone in...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2010/983202 |
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| author | A. R. Rote S. R. Bhalerao |
| author_facet | A. R. Rote S. R. Bhalerao |
| author_sort | A. R. Rote |
| collection | DOAJ |
| description | Three new simple, economic spectrophotometric methods were developed and validated for the estimation of nabumetone in bulk and tablet dosage form. First method includes determination of nabumetone at absorption maxima 330 nm, second method applied was area under curve for analysis of nabumetone in the wavelength range of 326-334 nm and third method was First order derivative spectra with scaling factor 4. Beer law obeyed in the concentration range of 10-30 μg/mL for all three methods. The correlation coefficients were found to be 0.9997, 0.9998 and 0.9998 by absorption maxima, area under curve and first order derivative spectra. Results of analysis were validated statistically and by performing recovery studies. The mean percent recoveries were found satisfactory for all three methods. The developed methods were also compared statistically using one way ANOVA. The proposed methods have been successfully applied for the estimation of nabumetone in bulk and pharmaceutical tablet dosage form. |
| format | Article |
| id | doaj-art-a300b41ff1624ff5a3c5af180cfe23b7 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-a300b41ff1624ff5a3c5af180cfe23b72025-02-03T01:09:08ZengWileyE-Journal of Chemistry0973-49452090-98102010-01-01741463146710.1155/2010/983202Development and Statistical Validation of Spectrophotometric Methods for the Estimation of Nabumetone in Tablet Dosage FormA. R. Rote0S. R. Bhalerao1Department of Pharmaceutical Chemistry, MGV's Pharmacy College, Panchavati, Mumbai - Agra Road, Nashik-422003, Maharashtra, IndiaDepartment of Pharmaceutical Chemistry, MGV's Pharmacy College, Panchavati, Mumbai - Agra Road, Nashik-422003, Maharashtra, IndiaThree new simple, economic spectrophotometric methods were developed and validated for the estimation of nabumetone in bulk and tablet dosage form. First method includes determination of nabumetone at absorption maxima 330 nm, second method applied was area under curve for analysis of nabumetone in the wavelength range of 326-334 nm and third method was First order derivative spectra with scaling factor 4. Beer law obeyed in the concentration range of 10-30 μg/mL for all three methods. The correlation coefficients were found to be 0.9997, 0.9998 and 0.9998 by absorption maxima, area under curve and first order derivative spectra. Results of analysis were validated statistically and by performing recovery studies. The mean percent recoveries were found satisfactory for all three methods. The developed methods were also compared statistically using one way ANOVA. The proposed methods have been successfully applied for the estimation of nabumetone in bulk and pharmaceutical tablet dosage form.http://dx.doi.org/10.1155/2010/983202 |
| spellingShingle | A. R. Rote S. R. Bhalerao Development and Statistical Validation of Spectrophotometric Methods for the Estimation of Nabumetone in Tablet Dosage Form E-Journal of Chemistry |
| title | Development and Statistical Validation of Spectrophotometric Methods for the Estimation of Nabumetone in Tablet Dosage Form |
| title_full | Development and Statistical Validation of Spectrophotometric Methods for the Estimation of Nabumetone in Tablet Dosage Form |
| title_fullStr | Development and Statistical Validation of Spectrophotometric Methods for the Estimation of Nabumetone in Tablet Dosage Form |
| title_full_unstemmed | Development and Statistical Validation of Spectrophotometric Methods for the Estimation of Nabumetone in Tablet Dosage Form |
| title_short | Development and Statistical Validation of Spectrophotometric Methods for the Estimation of Nabumetone in Tablet Dosage Form |
| title_sort | development and statistical validation of spectrophotometric methods for the estimation of nabumetone in tablet dosage form |
| url | http://dx.doi.org/10.1155/2010/983202 |
| work_keys_str_mv | AT arrote developmentandstatisticalvalidationofspectrophotometricmethodsfortheestimationofnabumetoneintabletdosageform AT srbhalerao developmentandstatisticalvalidationofspectrophotometricmethodsfortheestimationofnabumetoneintabletdosageform |