Hyphal penetration is the major pathway of translocation of Candida albicans across the blood-cerebrospinal fluid barrier

Hyphal penetration is the major pathway of translocation of Candida albicans across the blood-cerebrospinal fluid barrier

Abstract Background Despite the availability of potent antifungal compounds, invasive fungal disease poses significant morbidity and mortality in immunocompromised patients. Candida albicans is one of the leading pathogens in this setting, and may affect the central nervous system (CNS), which is an...

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Bibliographic Details
Main Authors: S. Schmidt, C. Schwerk, H. Schroten, H. Ishikawa, R. Schubert, T. Lehrnbecher, H. Rudolph
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Fluids and Barriers of the CNS
Subjects:
Blood cerebrospinal fluid barrier
Choroid plexus
C. albicans
Hyphal penetration
Tight junctions
Online Access:https://doi.org/10.1186/s12987-025-00644-x
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