Deoxybouvardin-glucoside induces apoptosis in non-small cell lung cancer cells by targeting EGFR/MET and AKT signaling pathway

Deoxybouvardin-glucoside induces apoptosis in non-small cell lung cancer cells by targeting EGFR/MET and AKT signaling pathway

Non-small cell lung cancer (NSCLC) is a leading cause of cancer-related deaths worldwide. Its treatment is complicated due to the development of resistance to conventional chemotherapy and targeted therapy. Deoxybouvardin and related cyclic hexapeptides reportedly exhibit antitumor activities, but t...

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Bibliographic Details
Main Authors: Na Yeong Lee, Sang Hoon Joo, A-Young Nam, Seung-On Lee, Goo Yoon, Seung-sik Cho, Yung Hyun Choi, Jin Woo Park, Jung-Hyun Shim
Format: Article
Language:English
Published: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund 2024-10-01
Series:EXCLI Journal : Experimental and Clinical Sciences
Subjects:
deoxybouvardin glucoside
non-small cell lung cancer
egfr/met/akt
cell cycle
reactive oxygen species
apoptosis
Online Access:https://www.excli.de/excli/article/view/7359
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