Comparison Of Clinical Efficacy Of Combined Versus Monotherapy Of Oral Zinc And Probiotic In Pediatric Acute Diarrhoea At Benazir Bhutto Shaheed Teaching Hospital, Abbottabad
Objective: Evaluation of effectiveness of zinc/ probiotics alone and in combination in children with acute diarrhoea. Place of Study: The study was conducted from May-Dec 2017 at Benazir Bhutto Shaheed Teaching Hospital Abbottabad. Methodology: Single centered, randomized controlled clinical trial...
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| Format: | Article |
| Language: | English |
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Bahria Univerisy Health Sciences, Campus Karachi
2021-03-01
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| Series: | Journal of Bahria University Medical and Dental College |
| Online Access: | https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/516 |
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| author | Anila Farhat Asma Shaukat Noman Sadiq |
| author_facet | Anila Farhat Asma Shaukat Noman Sadiq |
| author_sort | Anila Farhat |
| collection | DOAJ |
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Objective: Evaluation of effectiveness of zinc/ probiotics alone and in combination in children with acute diarrhoea.
Place of Study: The study was conducted from May-Dec 2017 at Benazir Bhutto Shaheed Teaching Hospital Abbottabad.
Methodology: Single centered, randomized controlled clinical trial was performed in 150 children of either sex (6 months
-10 years) with acute diarrhoea having stool frequency of > 5semi liquid stools per day. Patients were divided into three
groups with fifty children in each group on the basis of treatment modality given. Group A received zinc orally (1-2mg/kg/day
for five days along ORS and/or IV fluids if required), Group B patients were given one to two sachets of probiotics /day
(saccharomyces boulardii) according to age for five days + ORS and /or IV fluid while Group C was administered
combination of zinc and probiotics for five days along with ORS and /or IV fluids. Response to treatment was determined
on the basis of decrease in frequency of stools i.e. <3 formed stools /day after 72 hours of commencement of treatment.
We have also studied the relationship between hygiene and food intake practices with the occurrence of diarrhoea in children.
Results: Acute diarrhoea was found to be more prevalent in children with poor hygiene practices and using unboiled water.
Among the treatment groups, at the end of 3rd day total of forty eight (96%) patients in group C had improved consistency
of stools as well as decrease in diarrhoea frequency to less than three formed stools per day while in groups A and B thirty
nine (78%) and sixteen (32%) patients respectively showed response to treatment in 72 hours.
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| format | Article |
| id | doaj-art-a2e99a62ad694faaa86d3b4781c99dd8 |
| institution | DOAJ |
| issn | 2220-7562 2617-9482 |
| language | English |
| publishDate | 2021-03-01 |
| publisher | Bahria Univerisy Health Sciences, Campus Karachi |
| record_format | Article |
| series | Journal of Bahria University Medical and Dental College |
| spelling | doaj-art-a2e99a62ad694faaa86d3b4781c99dd82025-08-20T03:11:10ZengBahria Univerisy Health Sciences, Campus KarachiJournal of Bahria University Medical and Dental College2220-75622617-94822021-03-018410.51985/JBUMDC2018061Comparison Of Clinical Efficacy Of Combined Versus Monotherapy Of Oral Zinc And Probiotic In Pediatric Acute Diarrhoea At Benazir Bhutto Shaheed Teaching Hospital, AbbottabadAnila FarhatAsma ShaukatNoman Sadiq Objective: Evaluation of effectiveness of zinc/ probiotics alone and in combination in children with acute diarrhoea. Place of Study: The study was conducted from May-Dec 2017 at Benazir Bhutto Shaheed Teaching Hospital Abbottabad. Methodology: Single centered, randomized controlled clinical trial was performed in 150 children of either sex (6 months -10 years) with acute diarrhoea having stool frequency of > 5semi liquid stools per day. Patients were divided into three groups with fifty children in each group on the basis of treatment modality given. Group A received zinc orally (1-2mg/kg/day for five days along ORS and/or IV fluids if required), Group B patients were given one to two sachets of probiotics /day (saccharomyces boulardii) according to age for five days + ORS and /or IV fluid while Group C was administered combination of zinc and probiotics for five days along with ORS and /or IV fluids. Response to treatment was determined on the basis of decrease in frequency of stools i.e. <3 formed stools /day after 72 hours of commencement of treatment. We have also studied the relationship between hygiene and food intake practices with the occurrence of diarrhoea in children. Results: Acute diarrhoea was found to be more prevalent in children with poor hygiene practices and using unboiled water. Among the treatment groups, at the end of 3rd day total of forty eight (96%) patients in group C had improved consistency of stools as well as decrease in diarrhoea frequency to less than three formed stools per day while in groups A and B thirty nine (78%) and sixteen (32%) patients respectively showed response to treatment in 72 hours. https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/516 |
| spellingShingle | Anila Farhat Asma Shaukat Noman Sadiq Comparison Of Clinical Efficacy Of Combined Versus Monotherapy Of Oral Zinc And Probiotic In Pediatric Acute Diarrhoea At Benazir Bhutto Shaheed Teaching Hospital, Abbottabad Journal of Bahria University Medical and Dental College |
| title | Comparison Of Clinical Efficacy Of Combined Versus Monotherapy Of Oral Zinc And Probiotic In Pediatric Acute Diarrhoea At Benazir Bhutto Shaheed Teaching Hospital, Abbottabad |
| title_full | Comparison Of Clinical Efficacy Of Combined Versus Monotherapy Of Oral Zinc And Probiotic In Pediatric Acute Diarrhoea At Benazir Bhutto Shaheed Teaching Hospital, Abbottabad |
| title_fullStr | Comparison Of Clinical Efficacy Of Combined Versus Monotherapy Of Oral Zinc And Probiotic In Pediatric Acute Diarrhoea At Benazir Bhutto Shaheed Teaching Hospital, Abbottabad |
| title_full_unstemmed | Comparison Of Clinical Efficacy Of Combined Versus Monotherapy Of Oral Zinc And Probiotic In Pediatric Acute Diarrhoea At Benazir Bhutto Shaheed Teaching Hospital, Abbottabad |
| title_short | Comparison Of Clinical Efficacy Of Combined Versus Monotherapy Of Oral Zinc And Probiotic In Pediatric Acute Diarrhoea At Benazir Bhutto Shaheed Teaching Hospital, Abbottabad |
| title_sort | comparison of clinical efficacy of combined versus monotherapy of oral zinc and probiotic in pediatric acute diarrhoea at benazir bhutto shaheed teaching hospital abbottabad |
| url | https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/516 |
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