Liver Metastases in Pancreatic Acinar Cell Carcinoma Treated with Selective Internal Radiation Therapy with Y-90 Resin Microspheres
Background. Pancreatic acinar cell carcinoma (PACC) is a rare tumor. Surgical resection is the treatment of choice when feasible, but there are no clear recommendations for patients with advanced disease. Liver-directed therapy with Y-90 selective internal radiation therapy (SIRT) has been used to t...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2017/1847428 |
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| author | Felipe Nasser Joaquim Maurício Motta Leal Filho Breno Boueri Affonso Francisco Leonardo Galastri Rafael Noronha Cavalcante Diego Lima Nava Martins Vanderlei Segatelli Lilian Yuri Itaya Yamaga Rene Claudio Gansl Bernardino Tranchesi Junior Antônio Luiz de Vasconcellos Macedo |
| author_facet | Felipe Nasser Joaquim Maurício Motta Leal Filho Breno Boueri Affonso Francisco Leonardo Galastri Rafael Noronha Cavalcante Diego Lima Nava Martins Vanderlei Segatelli Lilian Yuri Itaya Yamaga Rene Claudio Gansl Bernardino Tranchesi Junior Antônio Luiz de Vasconcellos Macedo |
| author_sort | Felipe Nasser |
| collection | DOAJ |
| description | Background. Pancreatic acinar cell carcinoma (PACC) is a rare tumor. Surgical resection is the treatment of choice when feasible, but there are no clear recommendations for patients with advanced disease. Liver-directed therapy with Y-90 selective internal radiation therapy (SIRT) has been used to treat hepatic metastases from pancreatic tumors. We describe a case of PACC liver metastases treated with SIRT. Case Report. 59-year-old man was admitted with an infiltrative, solid lesion in pancreatic tail diagnosed as PACC. Lymph nodes in the hepatic hilum were enlarged, and many metastatic liver nodules were observed. After partial pancreatectomy, the left and right lobes of the liver were separately treated with Y-90 resin microspheres. Follow-up imaging revealed that all hepatic nodules shrank by at least 50%, and 3 nodules disappeared completely. Lipase concentration was 8407 U/L at baseline, rose to 12,705 U/L after pancreatectomy, and declined to 344 U/L after SIRT. Multiple rounds of chemotherapy in the subsequent year shrank the hepatic tumors further; disease then progressed, but a third line of chemotherapy shrank the tumors again, 16 months after SIRT treatment. Conclusion. SIRT had a positive effect on liver metastases from PACC. In conjunction with systemic therapy, SIRT can achieve sustained disease control. |
| format | Article |
| id | doaj-art-a2e262d1245645ce9bb841e663a883ee |
| institution | Kabale University |
| issn | 2090-6587 2090-6595 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hepatology |
| spelling | doaj-art-a2e262d1245645ce9bb841e663a883ee2025-02-03T01:09:23ZengWileyCase Reports in Hepatology2090-65872090-65952017-01-01201710.1155/2017/18474281847428Liver Metastases in Pancreatic Acinar Cell Carcinoma Treated with Selective Internal Radiation Therapy with Y-90 Resin MicrospheresFelipe Nasser0Joaquim Maurício Motta Leal Filho1Breno Boueri Affonso2Francisco Leonardo Galastri3Rafael Noronha Cavalcante4Diego Lima Nava Martins5Vanderlei Segatelli6Lilian Yuri Itaya Yamaga7Rene Claudio Gansl8Bernardino Tranchesi Junior9Antônio Luiz de Vasconcellos Macedo10Interventional Radiology Unit, Hospital Israelita Albert Einstein, Av. Albert Einstein 627/701, Morumbi, 05652-900 São Paulo, SP, BrazilInterventional Radiology Unit, Hospital Israelita Albert Einstein, Av. Albert Einstein 627/701, Morumbi, 05652-900 São Paulo, SP, BrazilInterventional Radiology Unit, Hospital Israelita Albert Einstein, Av. Albert Einstein 627/701, Morumbi, 05652-900 São Paulo, SP, BrazilInterventional Radiology Unit, Hospital Israelita Albert Einstein, Av. Albert Einstein 627/701, Morumbi, 05652-900 São Paulo, SP, BrazilInterventional Radiology Unit, Hospital Israelita Albert Einstein, Av. Albert Einstein 627/701, Morumbi, 05652-900 São Paulo, SP, BrazilInterventional Radiology Unit, Hospital Israelita Albert Einstein, Av. Albert Einstein 627/701, Morumbi, 05652-900 São Paulo, SP, BrazilPathology Department, Hospital Israelita Albert Einstein, Av. Albert Einstein 627/701, Morumbi, 05652-900 São Paulo, SP, BrazilNuclear Medicine Unit, Hospital Israelita Albert Einstein, Av. Albert Einstein 627/701, Morumbi, 05652-900 São Paulo, SP, BrazilOncology Department, Hospital Israelita Albert Einstein, Av. Albert Einstein 627/701, Morumbi, 05652-900 São Paulo, SP, BrazilCardiology Department, Hospital Israelita Albert Einstein, Av. Albert Einstein 627/701, Morumbi, 05652-900 São Paulo, SP, BrazilGeneral and Oncological Surgery, Hospital Israelita Albert Einstein, Av. Albert Einstein 627/701, Morumbi, 05652-900 São Paulo, SP, BrazilBackground. Pancreatic acinar cell carcinoma (PACC) is a rare tumor. Surgical resection is the treatment of choice when feasible, but there are no clear recommendations for patients with advanced disease. Liver-directed therapy with Y-90 selective internal radiation therapy (SIRT) has been used to treat hepatic metastases from pancreatic tumors. We describe a case of PACC liver metastases treated with SIRT. Case Report. 59-year-old man was admitted with an infiltrative, solid lesion in pancreatic tail diagnosed as PACC. Lymph nodes in the hepatic hilum were enlarged, and many metastatic liver nodules were observed. After partial pancreatectomy, the left and right lobes of the liver were separately treated with Y-90 resin microspheres. Follow-up imaging revealed that all hepatic nodules shrank by at least 50%, and 3 nodules disappeared completely. Lipase concentration was 8407 U/L at baseline, rose to 12,705 U/L after pancreatectomy, and declined to 344 U/L after SIRT. Multiple rounds of chemotherapy in the subsequent year shrank the hepatic tumors further; disease then progressed, but a third line of chemotherapy shrank the tumors again, 16 months after SIRT treatment. Conclusion. SIRT had a positive effect on liver metastases from PACC. In conjunction with systemic therapy, SIRT can achieve sustained disease control.http://dx.doi.org/10.1155/2017/1847428 |
| spellingShingle | Felipe Nasser Joaquim Maurício Motta Leal Filho Breno Boueri Affonso Francisco Leonardo Galastri Rafael Noronha Cavalcante Diego Lima Nava Martins Vanderlei Segatelli Lilian Yuri Itaya Yamaga Rene Claudio Gansl Bernardino Tranchesi Junior Antônio Luiz de Vasconcellos Macedo Liver Metastases in Pancreatic Acinar Cell Carcinoma Treated with Selective Internal Radiation Therapy with Y-90 Resin Microspheres Case Reports in Hepatology |
| title | Liver Metastases in Pancreatic Acinar Cell Carcinoma Treated with Selective Internal Radiation Therapy with Y-90 Resin Microspheres |
| title_full | Liver Metastases in Pancreatic Acinar Cell Carcinoma Treated with Selective Internal Radiation Therapy with Y-90 Resin Microspheres |
| title_fullStr | Liver Metastases in Pancreatic Acinar Cell Carcinoma Treated with Selective Internal Radiation Therapy with Y-90 Resin Microspheres |
| title_full_unstemmed | Liver Metastases in Pancreatic Acinar Cell Carcinoma Treated with Selective Internal Radiation Therapy with Y-90 Resin Microspheres |
| title_short | Liver Metastases in Pancreatic Acinar Cell Carcinoma Treated with Selective Internal Radiation Therapy with Y-90 Resin Microspheres |
| title_sort | liver metastases in pancreatic acinar cell carcinoma treated with selective internal radiation therapy with y 90 resin microspheres |
| url | http://dx.doi.org/10.1155/2017/1847428 |
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