PRECLINICAL HEMOCOMPATIBILITY STUDIES FOR IMPLANTABLE MEDICAL DEVICES: REVIEW AND EXPERIMENTAL RESEARCH RESULTS
Active use of medical devices in contact with the blood stream has created the need to articulate the testing requirements of such products [1], various methods of modelling and assessment of potential complications. One of the most important aspects of testing such products is to evaluate their dir...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-01-01
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| Series: | Разработка и регистрация лекарственных средств |
| Subjects: | |
| Online Access: | https://www.pharmjournal.ru/jour/article/view/334 |
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| author | M. D. Boyarskiy Y. V. Tarasov Y. I. Philippov N. P. Sachivkina Ya. M. Stanishevkiy |
| author_facet | M. D. Boyarskiy Y. V. Tarasov Y. I. Philippov N. P. Sachivkina Ya. M. Stanishevkiy |
| author_sort | M. D. Boyarskiy |
| collection | DOAJ |
| description | Active use of medical devices in contact with the blood stream has created the need to articulate the testing requirements of such products [1], various methods of modelling and assessment of potential complications. One of the most important aspects of testing such products is to evaluate their direct impact on blood. To obtain objective results of the study any modeling should be as close as possible to the situation of clinical use and reproduce the characteristics of blood flow. And also take into account the possibility of the use of anticoagulants and introducing in the model additional pharmacological preparations if they can influence the biochemical and physical characteristics of blood and their use is inextricably linked to the use of the product. The present article contains the results of the conducted scientific-research and experimental-design works on creation of the device to simulate the conditions of the blood flow to the preclinical testing of experimental samples of materials and devices intended for implantation in the human body for permanent or prolonged contact with blood |
| format | Article |
| id | doaj-art-a2d4e0e5ce4e451590c42b45e99c6c3e |
| institution | Kabale University |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| publishDate | 2019-01-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj-art-a2d4e0e5ce4e451590c42b45e99c6c3e2025-08-20T03:39:29ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492019-01-0101168176334PRECLINICAL HEMOCOMPATIBILITY STUDIES FOR IMPLANTABLE MEDICAL DEVICES: REVIEW AND EXPERIMENTAL RESEARCH RESULTSM. D. Boyarskiy0Y. V. Tarasov1Y. I. Philippov2N. P. Sachivkina3Ya. M. Stanishevkiy4Federal state institution "Endocrinology research centre"Federal state institution "Endocrinology research centre"Federal state institution "Endocrinology research centre"Federal state autonomous educational institution of higher professional education "Russian peoples friendship University"Federal state autonomous educational institution of higher professional education "Russian peoples friendship University"Active use of medical devices in contact with the blood stream has created the need to articulate the testing requirements of such products [1], various methods of modelling and assessment of potential complications. One of the most important aspects of testing such products is to evaluate their direct impact on blood. To obtain objective results of the study any modeling should be as close as possible to the situation of clinical use and reproduce the characteristics of blood flow. And also take into account the possibility of the use of anticoagulants and introducing in the model additional pharmacological preparations if they can influence the biochemical and physical characteristics of blood and their use is inextricably linked to the use of the product. The present article contains the results of the conducted scientific-research and experimental-design works on creation of the device to simulate the conditions of the blood flow to the preclinical testing of experimental samples of materials and devices intended for implantation in the human body for permanent or prolonged contact with bloodhttps://www.pharmjournal.ru/jour/article/view/334preclinical studyex vivobloodbiocomparabilitysimulationimplantation |
| spellingShingle | M. D. Boyarskiy Y. V. Tarasov Y. I. Philippov N. P. Sachivkina Ya. M. Stanishevkiy PRECLINICAL HEMOCOMPATIBILITY STUDIES FOR IMPLANTABLE MEDICAL DEVICES: REVIEW AND EXPERIMENTAL RESEARCH RESULTS Разработка и регистрация лекарственных средств preclinical study ex vivo blood biocomparability simulation implantation |
| title | PRECLINICAL HEMOCOMPATIBILITY STUDIES FOR IMPLANTABLE MEDICAL DEVICES: REVIEW AND EXPERIMENTAL RESEARCH RESULTS |
| title_full | PRECLINICAL HEMOCOMPATIBILITY STUDIES FOR IMPLANTABLE MEDICAL DEVICES: REVIEW AND EXPERIMENTAL RESEARCH RESULTS |
| title_fullStr | PRECLINICAL HEMOCOMPATIBILITY STUDIES FOR IMPLANTABLE MEDICAL DEVICES: REVIEW AND EXPERIMENTAL RESEARCH RESULTS |
| title_full_unstemmed | PRECLINICAL HEMOCOMPATIBILITY STUDIES FOR IMPLANTABLE MEDICAL DEVICES: REVIEW AND EXPERIMENTAL RESEARCH RESULTS |
| title_short | PRECLINICAL HEMOCOMPATIBILITY STUDIES FOR IMPLANTABLE MEDICAL DEVICES: REVIEW AND EXPERIMENTAL RESEARCH RESULTS |
| title_sort | preclinical hemocompatibility studies for implantable medical devices review and experimental research results |
| topic | preclinical study ex vivo blood biocomparability simulation implantation |
| url | https://www.pharmjournal.ru/jour/article/view/334 |
| work_keys_str_mv | AT mdboyarskiy preclinicalhemocompatibilitystudiesforimplantablemedicaldevicesreviewandexperimentalresearchresults AT yvtarasov preclinicalhemocompatibilitystudiesforimplantablemedicaldevicesreviewandexperimentalresearchresults AT yiphilippov preclinicalhemocompatibilitystudiesforimplantablemedicaldevicesreviewandexperimentalresearchresults AT npsachivkina preclinicalhemocompatibilitystudiesforimplantablemedicaldevicesreviewandexperimentalresearchresults AT yamstanishevkiy preclinicalhemocompatibilitystudiesforimplantablemedicaldevicesreviewandexperimentalresearchresults |