The Best Anticoagulation Strategy for Cirrhotic Patients who Underwent Splenectomy: A Network Meta-Analysis
Objective. To determine the best anticoagulation strategy for the patients who underwent splenectomy with cirrhosis through network meta-analysis. Methods. We conducted a systematic review of the literature in PubMed, Embase, and the Cochrane Library database. We extracted data on incidence of Porta...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2017/9216172 |
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| author | Cheng Gong Xian Qin Jian Yang Tao Guo |
| author_facet | Cheng Gong Xian Qin Jian Yang Tao Guo |
| author_sort | Cheng Gong |
| collection | DOAJ |
| description | Objective. To determine the best anticoagulation strategy for the patients who underwent splenectomy with cirrhosis through network meta-analysis. Methods. We conducted a systematic review of the literature in PubMed, Embase, and the Cochrane Library database. We extracted data on incidence of Portal vein system thrombosis (PVST) from studies that compared various anticoagulation strategies for use with patients who underwent splenectomy with cirrhosis. Network meta-analysis was conducted in ADDIS by evaluating the different incidence of PVST. Consistency and inconsistency models were developed to identify differences among the therapeutic strategies. Cumulative probability was utilized to rank the strategies under examination. Results. A total of 11 studies containing 1153 patients were included in the network meta-analysis. The results revealed that the application of Antithrombin III was the best anticoagulation option for patients who underwent splenectomy with cirrhosis (P=0.59). The data of consistency and inconsistency models exhibited basically consistent and showed good convergence. Conclusions. Application of Antithrombin III seemed to be the best anticoagulation strategy for cirrhotic patients who underwent splenectomy and should be considered a first-choice clinical reference. |
| format | Article |
| id | doaj-art-a2c36a2b79b3414d8eaba9bc41a5f02e |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-a2c36a2b79b3414d8eaba9bc41a5f02e2025-02-03T06:44:31ZengWileyGastroenterology Research and Practice1687-61211687-630X2017-01-01201710.1155/2017/92161729216172The Best Anticoagulation Strategy for Cirrhotic Patients who Underwent Splenectomy: A Network Meta-AnalysisCheng Gong0Xian Qin1Jian Yang2Tao Guo3Department of General Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, ChinaDepartment of General Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, ChinaSchool of Nursing, Huanggang Polytechnic College, Huanggang, 438002, ChinaDepartment of General Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, ChinaObjective. To determine the best anticoagulation strategy for the patients who underwent splenectomy with cirrhosis through network meta-analysis. Methods. We conducted a systematic review of the literature in PubMed, Embase, and the Cochrane Library database. We extracted data on incidence of Portal vein system thrombosis (PVST) from studies that compared various anticoagulation strategies for use with patients who underwent splenectomy with cirrhosis. Network meta-analysis was conducted in ADDIS by evaluating the different incidence of PVST. Consistency and inconsistency models were developed to identify differences among the therapeutic strategies. Cumulative probability was utilized to rank the strategies under examination. Results. A total of 11 studies containing 1153 patients were included in the network meta-analysis. The results revealed that the application of Antithrombin III was the best anticoagulation option for patients who underwent splenectomy with cirrhosis (P=0.59). The data of consistency and inconsistency models exhibited basically consistent and showed good convergence. Conclusions. Application of Antithrombin III seemed to be the best anticoagulation strategy for cirrhotic patients who underwent splenectomy and should be considered a first-choice clinical reference.http://dx.doi.org/10.1155/2017/9216172 |
| spellingShingle | Cheng Gong Xian Qin Jian Yang Tao Guo The Best Anticoagulation Strategy for Cirrhotic Patients who Underwent Splenectomy: A Network Meta-Analysis Gastroenterology Research and Practice |
| title | The Best Anticoagulation Strategy for Cirrhotic Patients who Underwent Splenectomy: A Network Meta-Analysis |
| title_full | The Best Anticoagulation Strategy for Cirrhotic Patients who Underwent Splenectomy: A Network Meta-Analysis |
| title_fullStr | The Best Anticoagulation Strategy for Cirrhotic Patients who Underwent Splenectomy: A Network Meta-Analysis |
| title_full_unstemmed | The Best Anticoagulation Strategy for Cirrhotic Patients who Underwent Splenectomy: A Network Meta-Analysis |
| title_short | The Best Anticoagulation Strategy for Cirrhotic Patients who Underwent Splenectomy: A Network Meta-Analysis |
| title_sort | best anticoagulation strategy for cirrhotic patients who underwent splenectomy a network meta analysis |
| url | http://dx.doi.org/10.1155/2017/9216172 |
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