Cerebrospinal fluid leak-associated ventriculitis – a case report
We present a case of a 74-year-old woman with headaches, pyrexia and intermittent right-sided otorrhoea and rhinorrhoea. Her nasal discharge tested positive for beta-2-transferrin, confirming a cerebrospinal fluid (CSF) leak. High-resolution CT (HRCT) mastoids showed a defect in the right tegmen, an...
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Elsevier
2025-01-01
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| Series: | Clinical Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1470211824054642 |
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| author | Amir Waheed Faryal Amir |
| author_facet | Amir Waheed Faryal Amir |
| author_sort | Amir Waheed |
| collection | DOAJ |
| description | We present a case of a 74-year-old woman with headaches, pyrexia and intermittent right-sided otorrhoea and rhinorrhoea. Her nasal discharge tested positive for beta-2-transferrin, confirming a cerebrospinal fluid (CSF) leak. High-resolution CT (HRCT) mastoids showed a defect in the right tegmen, and CSF within the middle ear and mastoid air cells. A gadolinium-enhanced MRI brain showed high signal in the occipital horns of the lateral ventricles with diffusion-weighted imaging (DWI) and a low signal with DWI-apparent diffusion coefficient (DWI-ADC), consistent with ventriculitis. She made an uneventful recovery after 6 weeks of intravenous antibiotics. The patient had surgical repair of bony defects to prevent recurrence.This highlights a rare case of ventriculitis associated with a spontaneous CSF leak, with no existing set diagnostic criteria, and high mortality. High clinical suspicion aided by appropriate imaging, and a multidisciplinary approach to management are imperative. |
| format | Article |
| id | doaj-art-a2c057842c3c402588aa0e4528bb65b7 |
| institution | Kabale University |
| issn | 1470-2118 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Medicine |
| spelling | doaj-art-a2c057842c3c402588aa0e4528bb65b72025-02-06T05:11:16ZengElsevierClinical Medicine1470-21182025-01-01251100279Cerebrospinal fluid leak-associated ventriculitis – a case reportAmir Waheed0Faryal Amir1Department of Acute & General Internal Medicine, Great Western Hospital, Marlborough Road, Swindon SN3 6BB, UK; Corresponding author: Amir Waheed, Great Western Hospital, Marlborough Road, Swindon SN3 6BB, UK.Department of General Internal Medicine, St Mary's Hospital, Praed Street, London W2 1NY, UKWe present a case of a 74-year-old woman with headaches, pyrexia and intermittent right-sided otorrhoea and rhinorrhoea. Her nasal discharge tested positive for beta-2-transferrin, confirming a cerebrospinal fluid (CSF) leak. High-resolution CT (HRCT) mastoids showed a defect in the right tegmen, and CSF within the middle ear and mastoid air cells. A gadolinium-enhanced MRI brain showed high signal in the occipital horns of the lateral ventricles with diffusion-weighted imaging (DWI) and a low signal with DWI-apparent diffusion coefficient (DWI-ADC), consistent with ventriculitis. She made an uneventful recovery after 6 weeks of intravenous antibiotics. The patient had surgical repair of bony defects to prevent recurrence.This highlights a rare case of ventriculitis associated with a spontaneous CSF leak, with no existing set diagnostic criteria, and high mortality. High clinical suspicion aided by appropriate imaging, and a multidisciplinary approach to management are imperative.http://www.sciencedirect.com/science/article/pii/S1470211824054642CSF leakVentriculitisBeta-2-transferrinCase report |
| spellingShingle | Amir Waheed Faryal Amir Cerebrospinal fluid leak-associated ventriculitis – a case report Clinical Medicine CSF leak Ventriculitis Beta-2-transferrin Case report |
| title | Cerebrospinal fluid leak-associated ventriculitis – a case report |
| title_full | Cerebrospinal fluid leak-associated ventriculitis – a case report |
| title_fullStr | Cerebrospinal fluid leak-associated ventriculitis – a case report |
| title_full_unstemmed | Cerebrospinal fluid leak-associated ventriculitis – a case report |
| title_short | Cerebrospinal fluid leak-associated ventriculitis – a case report |
| title_sort | cerebrospinal fluid leak associated ventriculitis a case report |
| topic | CSF leak Ventriculitis Beta-2-transferrin Case report |
| url | http://www.sciencedirect.com/science/article/pii/S1470211824054642 |
| work_keys_str_mv | AT amirwaheed cerebrospinalfluidleakassociatedventriculitisacasereport AT faryalamir cerebrospinalfluidleakassociatedventriculitisacasereport |