Amphetamine Positive Urine Toxicology Screen Secondary to Atomoxetine
The aim of this paper is to report the first case of atomoxetine leading to false-positive urine drug screen. An otherwise healthy 27-year-old female with a history of attention deficit hyperactivity disorder (ADHD) treated with atomoxetine had an acute onset tonic-clonic seizure. On arrival to the...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Psychiatry |
| Online Access: | http://dx.doi.org/10.1155/2013/381261 |
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| author | Joshua L. Fenderson Amy N. Stratton Jennifer S. Domingo Gerald O. Matthews Christopher D. Tan |
| author_facet | Joshua L. Fenderson Amy N. Stratton Jennifer S. Domingo Gerald O. Matthews Christopher D. Tan |
| author_sort | Joshua L. Fenderson |
| collection | DOAJ |
| description | The aim of this paper is to report the first case of atomoxetine leading to false-positive urine drug screen. An otherwise healthy 27-year-old female with a history of attention deficit hyperactivity disorder (ADHD) treated with atomoxetine had an acute onset tonic-clonic seizure. On arrival to the hospital, a urine toxicological drug screen with immunochemical cloned enzyme donor immunoassay (CEDIA) was performed. Results were positive for amphetamines; however, the presence of these substances could not be confirmed with urine gas chromatography-mass spectrometry (GC-MS). She denied any illicit drug use, herbal medications, or supplements, and her other prescription medications have not been previously known to cause a false-positive result for amphetamines. While stimulant treatments for ADHD could certainly result in a positive result on urine screen for amphetamines, there have been no reports of false-positive results for amphetamines secondary to patients using atomoxetine. We implicate atomoxetine, and/or its metabolites, as a compound or compounds which may interfere with urine drug immunoassays leading to false-positive results for amphetamines CEDIA assays. |
| format | Article |
| id | doaj-art-a2b03442ca344527943daca7cba958af |
| institution | Kabale University |
| issn | 2090-682X 2090-6838 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Psychiatry |
| spelling | doaj-art-a2b03442ca344527943daca7cba958af2025-02-03T01:22:35ZengWileyCase Reports in Psychiatry2090-682X2090-68382013-01-01201310.1155/2013/381261381261Amphetamine Positive Urine Toxicology Screen Secondary to AtomoxetineJoshua L. Fenderson0Amy N. Stratton1Jennifer S. Domingo2Gerald O. Matthews3Christopher D. Tan4Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USADepartment of Internal Medicine, Tripler Army Medical Center, 1 Jarrett White Road, Honolulu, HI 96859-5000, USADepartment of Psychiatry, Tripler Army Medical Center, 1 Jarrett White Road, Honolulu, HI 96859-5000, USADepartment of Psychiatry, Tripler Army Medical Center, 1 Jarrett White Road, Honolulu, HI 96859-5000, USADepartment of Pharmacy, Tripler Army Medical Center, 1 Jarrett White Road, Honolulu, HI 96859-5000, USAThe aim of this paper is to report the first case of atomoxetine leading to false-positive urine drug screen. An otherwise healthy 27-year-old female with a history of attention deficit hyperactivity disorder (ADHD) treated with atomoxetine had an acute onset tonic-clonic seizure. On arrival to the hospital, a urine toxicological drug screen with immunochemical cloned enzyme donor immunoassay (CEDIA) was performed. Results were positive for amphetamines; however, the presence of these substances could not be confirmed with urine gas chromatography-mass spectrometry (GC-MS). She denied any illicit drug use, herbal medications, or supplements, and her other prescription medications have not been previously known to cause a false-positive result for amphetamines. While stimulant treatments for ADHD could certainly result in a positive result on urine screen for amphetamines, there have been no reports of false-positive results for amphetamines secondary to patients using atomoxetine. We implicate atomoxetine, and/or its metabolites, as a compound or compounds which may interfere with urine drug immunoassays leading to false-positive results for amphetamines CEDIA assays.http://dx.doi.org/10.1155/2013/381261 |
| spellingShingle | Joshua L. Fenderson Amy N. Stratton Jennifer S. Domingo Gerald O. Matthews Christopher D. Tan Amphetamine Positive Urine Toxicology Screen Secondary to Atomoxetine Case Reports in Psychiatry |
| title | Amphetamine Positive Urine Toxicology Screen Secondary to Atomoxetine |
| title_full | Amphetamine Positive Urine Toxicology Screen Secondary to Atomoxetine |
| title_fullStr | Amphetamine Positive Urine Toxicology Screen Secondary to Atomoxetine |
| title_full_unstemmed | Amphetamine Positive Urine Toxicology Screen Secondary to Atomoxetine |
| title_short | Amphetamine Positive Urine Toxicology Screen Secondary to Atomoxetine |
| title_sort | amphetamine positive urine toxicology screen secondary to atomoxetine |
| url | http://dx.doi.org/10.1155/2013/381261 |
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